The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Effects of exercise on cellular and tissue aging
Open accessAbstract
The natural aging process is carried out by a progressive loss of homeostasis leading to a functional decline in cells and tissues. The accumulation of these changes stem from a multifactorial process on which both external (environmental and social) and internal (genetic and biological) risk factors contribute to the development of adult chronic diseases, including type 2 diabetes mellitus (T2D). Strategies that can slow cellular aging include changes in diet, lifestyle and drugs that modulate intracellular signaling. Exercise is a promising lifestyle intervention that has shown antiaging effects by extending lifespan and healthspan through decreasing the nine hallmarks of aging and age-associated inflammation. Herein, we review the effects of exercise to attenuate aging from a clinical to a cellular level, listing its effects upon various tissues and systems as well as its capacity to reverse many of the hallmarks of aging. Additionally, we suggest AMPK as a central regulator of the cellular effects of exercise due to its integrative effects in different tissues. These concepts are especially relevant in the setting of T2D, where cellular aging is accelerated and exercise can counteract these effects through the reviewed antiaging mechanisms.
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“Exercise training has been shown to reduce all the hallmarks of ageing9,3,38”
From Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence (2024) · cites this paper as [9]
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Qiu, Y., Fernández-García, B., Lehmann, H. I., Li, G., Kroemer, G., López-Otín, C., & Xiao, J. (2023) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.10.003 · Cited by 270
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Neurogenesis in aging and age-related neurodegenerative diseases
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Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting
Al‐Azab, M., Safi, M., Idiiatullina, E., Al‐Shaebi, F., & Zaky, M. Y. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00366-0 · Cited by 178
The Role of Immune Cells in Oxi-Inflamm-Aging
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Metadata
- Authors
- Carapeto, P. V., & Aguayo-Mazzucato, C.
- Affiliations
- Joslin Diabetes Center (US)
- Beta Cell Aging Lab, Joslin Diabetes Center, Harvard Medical School, Boston MA 02115, USA
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2021-05-13
- Volume
- 13
- Issue
- 10
- Pages
- 14522-14543
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC8202894
- OpenAlex
- W3162660575
- Cited by
- 107
- References
- 166
- Citations by year
- 2026: 21 · 2025: 23 · 2024: 31 · 2023: 14 · 2022: 13 · 2021: 5
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK036836)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- physical activity, cellular aging, tissue aging, hallmarks of aging, type 2 diabetes, AMPK, healthspan, lifespan extension, age-associated inflammation, lifestyle intervention
- MeSH terms
- Adenylate Kinase, Aging, Animals, Humans, Organ Specificity, Signal Transduction, Exercise, Cellular Senescence, Models, Animal
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