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Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test

Demidenko, Oleksandr, Barardo, Diogo, Budovskii, Valery, Finnemore, Robb, Palmer, Francis R., Kennedy, Brian K., Budovskaya, Yelena V.·2021·Aging
DOI 10.18632/aging.203736PMC PMC8660611
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Figure 1 TruAge age estimation and baseline chronological age are linearly correlated. The TruAge biological age is highly (adjusted R-squared = 0.77) statistically significantly (p-value = 2x10-9) correlated with chronological age of the 42 patients.
Figure 1 TruAge age estimation and baseline chronological age are linearly correlated. The TruAge biological age is highly (adjusted R-squared = 0.77) statistically significantly (p-value = 2x10-9) correlated with chronological age of the 42 patients.CC BY · PubMed Central
Figure 2 TruAge age estimation and baseline chronological age are linearly correlated, in both genders. The x-axis depicts DNA methylation age estimated by TruAge, and the y-axis the chronological age of the 42 patients at baseline. The pink and blue linear correlation plots depict the similarly high statistically significant linear correlation between both axes, for female and male patients, respectively.
Figure 2 TruAge age estimation and baseline chronological age are linearly correlated, in both genders. The x-axis depicts DNA methylation age estimated by TruAge, and the y-axis the chronological age of the 42 patients at baseline. The pink and blue linear correlation plots depict the similarly high statistically significant linear correlation between both axes, for female and male patients, respectively.CC BY · PubMed Central
Figure 3 CaAKG decreased methylation age among a homogeneous sub-population. The paired box plots represent the treatment effects at the patient and group level (n=13), between baseline and end of the trial (which on average had a duration of 7 months). The box plots depict the median and the 25th and 75th quartiles.
Figure 3 CaAKG decreased methylation age among a homogeneous sub-population. The paired box plots represent the treatment effects at the patient and group level (n=13), between baseline and end of the trial (which on average had a duration of 7 months). The box plots depict the median and the 25th and 75th quartiles.CC BY · PubMed Central
Figure 4 CaAKG decreased methylation age in the entire cohort. The paired box plots represent the treatment effects at the patient and group level (n=42), between baseline and end of the trial (which on average had a duration of 7 months). The box plots depict the median and the 25th and 75th quartiles.
Figure 4 CaAKG decreased methylation age in the entire cohort. The paired box plots represent the treatment effects at the patient and group level (n=42), between baseline and end of the trial (which on average had a duration of 7 months). The box plots depict the median and the 25th and 75th quartiles.CC BY · PubMed Central
Figure 5 CaAKG decreases methylation age regardless of gender. The image displays the effects of CaAKG on methylation age between the start and end of treatment, broken down by gender. For each gender, the red and blue paired box plots, depict the data at baseline and endpoint, respectively. The boxplots are based on the median and the 25th and 75th quartiles.
Figure 5 CaAKG decreases methylation age regardless of gender. The image displays the effects of CaAKG on methylation age between the start and end of treatment, broken down by gender. For each gender, the red and blue paired box plots, depict the data at baseline and endpoint, respectively. The boxplots are based on the median and the 25th and 75th quartiles.CC BY · PubMed Central
Figure 6 3D scatter plot of the covariates influencing CaAKG treatment efficacy. The x-axis refers to the difference, in years, between the chronological and biological ages at baseline (a patient in an older state will have larger positive value). The y-axis depicts the effect of CaAKG treatment in terms of years that the methylation age decreased (higher values indicate larger benefits). The z-axis is the chronological age at baseline (older patients will be “deeper”). The 3D plane was traced by using the linear regression of both covariates to treatment effect.
Figure 6 3D scatter plot of the covariates influencing CaAKG treatment efficacy. The x-axis refers to the difference, in years, between the chronological and biological ages at baseline (a patient in an older state will have larger positive value). The y-axis depicts the effect of CaAKG treatment in terms of years that the methylation age decreased (higher values indicate larger benefits). The z-axis is the chronological age at baseline (older patients will be “deeper”). The 3D plane was traced by using the linear regression of both covariates to treatment effect.CC BY · PubMed Central

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Citations

Cites

Research works printed but not linked: 25

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Metadata

Authors
Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer, F. R., Kennedy, B. K., & Budovskaya, Y. V.
Affiliations
  • TruMe Inc., Alameda, CA 94502, USA
  • Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University Singapore, Singapore 117456, Singapore
  • Ponce de Leon Health, Fernandina, FL 32034, USA
Venue
Aging
Publisher
Impact Journals, LLC
Published
2021-11-30
Volume
13
Issue
22
Pages
24485-24499
ISSN
1945-4589
DOI
10.18632/aging.203736
PMC
PMC8660611
Cited by
80
References
8
Language
en

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