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DNA methylation GrimAge version 2
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“Regardless of the development strategy, most current biomarkers of aging predict aging-related outcomes and identify factors associated with the pace of aging, in retrospective epidemiological studies 1-7.”
From Validation of biomarkers of aging (2024) · cites this paper as [4]
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DNA methylation GrimAge strongly predicts lifespan and healthspan
Lu, A. T., Quach, A., Wilson, J. G., Reiner, A. P., Aviv, A., Raj, K., Hou, L., Baccarelli, A. A., Li, Y., Stewart, J. D., et al. (2019) · Aging · doi:10.18632/aging.101684 · Cited by 2,540
Self-citationEpigenetic clock analysis of diet, exercise, education, and lifestyle factors
Quach, A., Levine, M. E., Tanaka, T., Lu, A. T., Chen, B. H., Ferrucci, L., Ritz, B., Bandinelli, S., Neuhouser, M. L., Beasley, J. M., et al. (2017) · Aging · doi:10.18632/aging.101168 · Cited by 801
Self-citationMeasuring biological age using omics data
Rutledge, J., Oh, H., & Wyss-Coray, T. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00511-7 · Cited by 570
Reversal of epigenetic aging and immunosenescent trends in humans.
Fahy, G. M., Brooke, R. T., Watson, J. P., Good, Z., Vasanawala, S. S., Maecker, H., Leipold, M. D., Lin, D. T. S., Kobor, M. S., & Horvath, S. (2019) · Aging Cell · doi:10.1111/acel.13028 · Cited by 477
Self-citationDNA methylation signatures in peripheral blood strongly predict all-cause mortality
Zhang, Y., Wilson, R., Heiss, J., Breitling, L. P., Saum, K.-U., Schöttker, B., Holleczek, B., Waldenberger, M., Peters, A., & Brenner, H. (2017) · Nature Communications · doi:10.1038/ncomms14617 · Cited by 382
An epigenetic predictor of death captures multi-modal measures of brain health
Hillary, R. F., Stevenson, A. J., Cox, S. R., McCartney, D. L., Harris, S. E., Seeboth, A., Higham, J., Sproul, D., Taylor, A. M., Redmond, P., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-019-0616-9 · Cited by 139
Self-citationEpigenetic Age Acceleration and Hearing: Observations From the Baltimore Longitudinal Study of Aging
Kuo, P.-L., Moore, A. Z., Lin, F. R., & Ferrucci, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.790926 · Cited by 23
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Cited by
Sorted by citations
Validation of biomarkers of aging
Moqri, M., Herzog, C., Poganik, J. R., Ying, K., Justice, J. N., Belsky, D. W., Higgins-Chen, A. T., Chen, B. H., Cohen, A. A., Fuellen, G., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02784-9 · Cited by 361
Self-citationBischoff-Ferrari, H. A., Gängler, S., Wieczorek, M., Belsky, D. W., Ryan, J., Kressig, R. W., Stähelin, H. B., Theiler, R., Dawson-Hughes, B., Rizzoli, R., et al. (2025) · Nature Aging · doi:10.1038/s43587-024-00793-y · Cited by 140
Self-citationQiao, X., Straight, B., Ngo, D., Hilton, C. E., Owuor Olungah, C., Naugle, A., Lalancette, C., & Needham, B. L. (2024) · Nature Communications · doi:10.1038/s41467-024-48426-7 · Cited by 10
Edwards, T., Long, Q., & Shen, L. (2026) · doi:10.64898/2026.10.17.759869
Hierarchical endpoints and win statistics for geromedicine trials
Abdellatif, M., Kim, Y., & Kroemer, G. (2026) · Nature Aging · doi:10.1038/s43587-026-01158-3
Metadata
- Authors
- Lu, A. T., Binder, A. M., Zhang, J., Yan, Q., Reiner, A. P., Cox, S. R., Corley, J., Harris, S. E., Kuo, P.-L., Moore, A. Z., Bandinelli, S., Stewart, J. D., Wang, C., Hamlat, E. J., Epel, E. S., Schwartz, J. D., Whitsel, E. A., Correa, A., Ferrucci, L., Marioni, R. E., & Horvath, S.
- Affiliations
- Dept. of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
- Population Sciences in the Pacific Program (Cancer Epidemiology), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI 96813, USA
- San Diego Institute of Science, Altos Labs, San Diego, CA 92121, USA
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, Scotland, UK
- Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
- Geriatric Unit, Local Health Unit Tuscany Centre, Firenze, Tuscany 40125, Italy
- Dept. of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27516-8050, USA
- Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
- Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA 94143-0848, USA
- Departments of Medicine and Population Health Science, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS 39216, USA
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, Scotland, UK
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2022-12-14
- ISSN
- 1945-4589
- PMC
- PMC9792204
- Cited by
- 216
- References
- 12
- Language
- en
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