Cited by 26

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing

Shvedova, Maria, Thanapaul, Rex Jeya Rajkumar Samdavid, Ha, Joy, Dhillon, Jannat, Shin, Grace H., Crouch, Jack, Gower, Adam C., Gritli, Sami, Roh, Daniel S.·2025·Aging

Published version of a preprint

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.18632/aging.206165

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Omega-3 fatty acids, when administered alongside senolytic therapies, may modulate the transient inflammatory responses associated with senescent cell clearance.

    “When administered alongside senolytic therapies, they may modulate the transient inflammatory responses associated with SnC clearance104.”

    From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [104]

    The Discussion describes transient inflammation following ABT-263 treatment and suggests it may result from senolysis-induced immune activation. The paper does not address omega-3 fatty acids or whether administering them alongside senolytics modulates that response (searched: omega-3 and co-treatment). (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 27

  1. Roh, 2022, Cellular Senescence in Aging, Tissue Repair, and Regeneration., Plast Reconstr Surg, 15, 4S, 10.1097/PRS.0000000000009667 · DOI
  2. Gorospe, 2020, Survey of senescent cell markers with age in human tissues., Aging (Albany NY), 1, 4052, 10.18632/aging.102903 · DOI · Paper page
  3. Maier, 2021, Senescence in tissue samples of humans with age-related diseases: A systematic review., Ageing Res Rev, 6, 101334, 10.1016/j.arr.2021.101334 · DOI
  4. Khosla, 2023, Senescent cells, senolytics and tissue repair: the devil may be in the dosing., Nat Aging, 3, 139, 10.1038/s43587-023-00365-6 · DOI
  5. Cavadas, 2022, Skin senescence: mechanisms and impact on whole-body aging., Trends Mol Med, 2, 97, 10.1016/j.molmed.2021.12.003 · DOI · Paper page
  6. Wlaschek, 2006, p16INK4A is a robustbiomarker of cellular aging in human skin., Aging Cell, 5, 379, 10.1111/j.1474-9726.2006.00231.x · DOI · Paper page
  7. Maier, 2012, The number of p16INK4a positive cells in human skin reflects biological age., Aging Cell, 1, 722, 10.1111/j.1474-9726.2012.00837.x · DOI · Paper page
  8. Herbig, 2007, Accumulation of senescent cells in mitotic tissue of aging primates., Mech Ageing Dev, 12, 36, 10.1016/j.mad.2006.11.008 · DOI · Paper page
  9. Chikenji, 2024, Cellular senescence and wound healing in aged and diabetic skin., Front Physiol, 1, 1344116, 10.3389/fphys.2024.1344116 · DOI
  10. Robbins, 2022, Targeting Cellular Senescence with Senotherapeutics: Development of New Approaches for Skin Care., Plast Reconstr Surg, 15, 12S, 10.1097/PRS.0000000000009668 · DOI
  11. Kirkland, 2022, Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation., Plast Reconstr Surg, 15, 20S, 10.1097/PRS.0000000000009669 · DOI
  12. Chung, 2022, Attenuation of intrinsic ageing of the skin via elimination of senescent dermal fibroblasts with senolytic drugs., J Eur Acad Dermatol Venereol, 3, 1125, 10.1111/jdv.18051 · DOI
  13. Campisi, 2010, The senescence-associated secretory phenotype: the dark side of tumor suppression., Annu Rev Pathol, 5, 99, 10.1146/annurev-pathol-121808-102144 · DOI · Paper page
  14. Sekiya, 2022, Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients., Stem Cell Res Ther, 1, 222, 10.1186/s13287-022-02901-4 · DOI
  15. Kishi, 2023, Navitoclax (ABT-263) Rejuvenates Human Skin by Eliminating Senescent Dermal Fibroblasts in a Mouse/Human Chimeric Model., Rejuvenation Res, 2, 9, 10.1089/rej.2022.0048 · DOI
  16. Xia, 2021, ABT-263 Reduces Hypertrophic Scars by Targeting Apoptosis of Myofibroblasts., Front Pharmacol, 1, 615505, 10.3389/fphar.2020.615505 · DOI
  17. Demaria, 2022, Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression., Nat Commun, 1, 7923, 10.1038/s41467-022-35657-9 · DOI
  18. Xiong, 2014, Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of navitoclax (ABT-263) induced thrombocytopenia., Cancer Chemother Pharmacol, 7, 593, 10.1007/s00280-014-2530-9 · DOI · Paper page
  19. Kirkland, 2016, Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors., Aging Cell, 1, 428, 10.1111/acel.12445 · DOI · Paper page
  20. Jordan, 2013, BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells., Cell Stem Cell, 1, 329, 10.1016/j.stem.2012.12.013 · DOI
  21. Naoki, 2020, Intracellular levels of reactive oxygen species correlate with ABT-263 sensitivity in non-small-cell lung cancer cells., Cancer Sci, 11, 3793, 10.1111/cas.14569 · DOI
  22. Passos, 2023, Cellular senescence: all roads lead to mitochondria., FEBS J, 29, 1186, 10.1111/febs.16361 · DOI · Paper page
  23. Fuchs, 2017, Inflammatory memory sensitizes skin epithelial stem cells to tissue damage., Nature, 55, 475, 10.1038/nature24271 · DOI · Paper page
  24. Murphy, 2020, The Pathobiology of Skin Aging: New Insights into an Old Dilemma., Am J Pathol, 19, 1356, 10.1016/j.ajpath.2020.03.007 · DOI
  25. Roh, 2021, An Insight into Aging, Senescence, and Their Impacts on Wound Healing., Adv Geriatr Med Res, 3, e210017, 10.20900/agmr20210017 · DOI
  26. Gingeras, 2013, STAR: ultrafast universal RNA-seq aligner., Bioinformatics, 2, 15, 10.1093/bioinformatics/bts635 · DOI · Paper page
  27. Anders, 2014, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2., Genome Biol, 1, 550, 10.1186/s13059-014-0550-8 · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Shvedova, M., Thanapaul, R. J. R. S., Ha, J., Dhillon, J., Shin, G. H., Crouch, J., Gower, A. C., Gritli, S., & Roh, D. S.
Venue
Aging
Published
2024-12-03
Volume
17
Issue
1
Pages
16-32
ISSN
1945-4589
Cited by
26
References
6
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review