Expression of the β3 subunit of Na+/K+-ATPase is increased in gastric cancer and regulates gastric cancer cell progression and prognosis via the PI3/AKT pathway
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// Li Li 1, * , Ru Feng 2, * , Qian Xu 2 , Feiyue Zhang 2 , Tong Liu 2 , Jiang Cao 3 and Sujuan Fei 1 1 Department of Gastroenterology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China 2 Department of Gastroenterology, Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China 3 Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China * These authors have contributed equally to this work Correspondence to: Jiang Cao, email: zimu05067@163.com Sujuan Fei, email: xyfyfeisj99@163.com Keywords: ATP1B3, proliferation, apoptosis, migration, gastric cancer Received: February 09, 2017 Accepted: August 26, 2017 Published: September 15, 2017 ABSTRACT ATP1B3 encodes the β3 subunit of Na + /K + -ATPase and is located in the q22-23 region of chromosome 3. Na + /K + -ATPase participates in normal cellular activities but also plays a crucial role in carcinogenesis. In the present study, we found that expression of the β3 subunit of Na + /K + -ATPase was increased in human gastric cancer tissues compared with that in normal matched tissues and that this increased expression predicted a poor outcome. ATP1B3 expression was elevated at both the mRNA and protein levels in gastric cancer cell lines relative to those in a normal gastric epithelial cell line. Interestingly, ATP1B3 knockdown significantly inhibited cell proliferation, colony-formation ability, migration, and invasion and increased apoptosis in human gastric carcinoma cell lines. Additionally, knockdown induced cell cycle arrest at the G2/M phase. Furthermore, we demonstrated that ATP1B3 silencing decreased the expression of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT) and phosphorylated AKT (p-AKT), indicating that ATP1B3 regulates gastric cancer cell progression via the PI3K/AKT signalling pathway. Hence, the β3 subunit of Na + /K + -ATPase plays an essential role in the tumourigenesis of gastric cancer and may be a potential prognostic and therapeutic target for the treatment of gastric cancer.
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Many of the genes in CisSig have been denoted as possible therapeutic targets in a variety of epithelial-based cancers.
“Furthermore, many of the genes have been denoted as possible therapeutic targets in a variety of epithelial-based cancers, such as CDC7 in oral squamous carcinoma30 and liver cancer31, ATP1B3 in gastric cancer32, and FKBP14 in ovarian cancer33.”
From Exploiting convergent phenotypes to derive a pan-cancer cisplatin response gene expression signature (2023) · cites this paper as [32]
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- Authors
- Li, L., Feng, R., Xu, Q., Zhang, F., Liu, T., Cao, J., & Fei, S.
- Affiliations
- Department of Gastroenterology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China
- Xuzhou Medical College (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
- Corresponding author
- Li, Li
- Feng, Ru
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2017-09-15
- Volume
- 8
- Issue
- 48
- Pages
- 84285-84299
- ISSN
- 1949-2553 (ISSN-L)
- PMC
- PMC5663595
- OpenAlex
- W2754780527
- Cited by
- 41
- References
- 41
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 11 · 2019: 2 · 2018: 3
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Oncotarget (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- gastric cancer, PI3K/Akt signaling, cell proliferation, apoptosis, cell migration and invasion, G2/M cell cycle arrest, prognosis, gene knockdown, oncogenes, tumor progression, phosphatidylinositol 3-kinase, Akt, Akt phosphorylation, chromosome 3
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