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Dissecting tRNA-derived fragment complexities using personalized transcriptomes reveals novel fragment classes and unexpected dependencies

Telonis, Aristeidis G., Loher, Phillipe, Honda, Shozo, Jing, Yi, Palazzo, Juan, Kirino, Yohei, Rigoutsos, Isidore·2015·Oncotarget
DOI 10.18632/oncotarget.4695PMC PMC4694795
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  • Various small ncRNAs directly regulate gene expression at posttranscriptional mRNA processing and ribosome biogenesis.

    “numerous studies have revealed the direct involvement of various small ncRNAs in regulation of gene expression at the levels of posttranscriptional mRNA processing (5–7) and ribosome biogenesis (8)”

    From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [7]

  • Consistent with a previous report on tRFs in human cell lines, there is a major difference in the size of fragments originating from nuclearly or mitochondrially encoded tRNA.

    “consistent with a previous report on tRFs in human cell lines (7), we observed a major difference in the size of fragments originating from either nuclearly or mitochondrially encoded tRNA (ntRNA and mtRNA, respectively).”

    From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [7]

  • tRFs are fragments of either mature or precursor tRNA molecules enzymatically cleaved by angiogenin, Dicer, RNaseZ, and RNaseP.

    “fragments of either mature of precursor tRNA molecules enzymatically cleaved by angiogenin (Ang), Dicer, RNaseZ, and RNaseP (7, 53)”

    From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [7]

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Authors
Telonis, A. G., Loher, P., Honda, S., Jing, Y., Palazzo, J., Kirino, Y., & Rigoutsos, I.
Affiliations
  • Computational Medicine Center, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA
  • Department of Pathology Anatomy and Cell Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2015-07-06
Volume
6
Issue
28
Pages
24797-24822
ISSN
1949-2553
DOI
10.18632/oncotarget.4695
PMC
PMC4694795
Cited by
180
References
3
Language
en

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