The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
httk: R Package for High-Throughput Toxicokinetics
Open accessAbstract
Thousands of chemicals have been profiled by high-throughput screening programs such as ToxCast and Tox21; these chemicals are tested in part because most of them have limited or no data on hazard, exposure, or toxicokinetics. Toxicokinetic models aid in predicting tissue concentrations resulting from chemical exposure, and a
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Citations
Cites
The Simcyp ® Population-based ADME Simulator
Jamei, M., Marciniak, S., Feng, K., Barnett, A., Tucker, G., & Rostami-Hodjegan, A. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250802691074 · Cited by 533
General approach for the calculation of tissue to plasma partition coefficients
Schmitt, W. (2008) · Toxicology in Vitro · doi:10.1016/j.tiv.2007.09.010 · Cited by 349 · cited 6×
“Vdist is used as the volume of the compartment and is calculated by summing the plasma volume and the products of each tissue to unbound plasma partition coefficient, its corresponding volume, and fub (Schmitt 2008b).”
Influential
Cited by
Thomas, R. S., Bahadori, T., Buckley, T. J., Cowden, J., Deisenroth, C., Dionisio, K. L., Frithsen, J. B., Grulke, C. M., Gwinn, M. R., Harrill, J. A., et al. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz058 · Cited by 373
Self-citationCiallella, H. L., & Zhu, H. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00393 · Cited by 227
Nyffeler, J., Willis, C., Lougee, R., Richard, A., Paul-Friedman, K., & Harrill, J. A. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114876 · Cited by 136
Nyffeler, J., Willis, C., Harris, F. R., Foster, M. J., Chambers, B., Culbreth, M., Brockway, R. E., Davidson-Fritz, S., Dawson, D., Shah, I., et al. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116513 · Cited by 67
Self-citationDawson, D. E., Lau, C., Pradeep, P., Sayre, R. R., Judson, R. S., Tornero-Velez, R., & Wambaugh, J. F. (2023) · Toxics · doi:10.3390/toxics11020098 · Cited by 56
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Metadata
- Authors
- Pearce, R. G., Setzer, R. W., Strope, C. L., Sipes, N. S., & Wambaugh, J. F.
- Venue
- Journal of Statistical Software
- Publisher
- Foundation for Open Access Statistic
- Published
- 2017
- Volume
- 79
- Issue
- 4
- Pages
- 1-26
- ISSN
- 1548-7660 (ISSN-L)
- OpenAlex
- W2734700870
- Cited by
- 298
- References
- 2
- FWCI
- 15.36
- Type
- journal article
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: httk: R Package for High-Throughput Toxicokinetics. https://app.cochat.ai/papers/10.18637/jss.v079.i04
- The paper
- Pearce, R. G., Setzer, R. W., Strope, C. L., Sipes, N. S., & Wambaugh, J. F. (2017). httk: R Package for High-Throughput Toxicokinetics. Journal of Statistical Software. https://doi.org/10.18637/jss.v079.i04
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
