Insulin/insulin-like growth factor signaling in C. elegans

Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span

Yanase, S., Yasuda, K., & Ishii, N. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00093-3 · Cited by 163

Second AKT: The rise of SGK in cancer signalling

Bruhn, M. A., Pearson, R. B., Hannan, R. D., & Sheppard, K. E. (2010) · Growth Factors · doi:10.3109/08977194.2010.518616 · Cited by 160

DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans

Pinkston-Gosse, J., & Kenyon, C. J. (2007) · Nature Genetics · doi:10.1038/ng.2007.1 · Cited by 157

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

Gil, E. B., Link, E. M., Liu, L. X., Johnson, C. D., & Lees, J. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2925 · Cited by 157

Specific insulin-like peptides encode sensory information to regulate distinct developmental processes

Cornils, A., Gloeck, M., Chen, Z., Zhang, Y., & Alcedo, J. (2011) · Development · doi:10.1242/dev.060905 · Cited by 156

Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress

Lamitina, S. T., & Strange, K. B. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00451.2004 · Cited by 155

New Insulin-Like Proteins with Atypical Disulfide Bond Pattern Characterized in Caenorhabditis elegans by Comparative Sequence Analysis and Homology ModelingPreprint

Duret, L., Guex, N., Peitsch, M. C., & Bairoch, A. (1998) · Genome Research · doi:10.1101/gr.8.4.348 · Cited by 154

Specific SKN-1/Nrf Stress Responses to Perturbations in Translation Elongation and Proteasome Activity

Li, X., Matilainen, O., Jin, C., Glover-Cutter, K. M., Holmberg, C. I., & Blackwell, T. K. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002119 · Cited by 153

MAPK/ERK Signaling Regulates Insulin Sensitivity to Control Glucose Metabolism in Drosophila

Zhang, W., Thompson, B. J., Hietakangas, V., & Cohen, S. M. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002429 · Cited by 152

ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylationPreprint

Zhang, W., Hietakangas, V., Wee, S., Lim, S. C., Gunaratne, J., & Cohen, S. M. (2013) · Genes & Development · doi:10.1101/gad.201731.112 · Cited by 152

Two Insulin-like Peptides Antagonistically Regulate Aversive Olfactory Learning in C. elegans

Chen, Z., Hendricks, M., Cornils, A., Maier, W., Alcedo, J., & Zhang, Y. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.025 · Cited by 150

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

Rouault, J.-P., Kuwabara, P. E., Sinilnikova, O. M., Duret, L., Thierry‐Mieg, D., & Billaud, M. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80143-2 · Cited by 145

The cytohesin Steppke is essential for insulin signalling in Drosophila

Fuß, B., Becker, T., Zinke, I., & Hoch, M. (2006) · Nature · doi:10.1038/nature05412 · Cited by 140

New genes that extend Caenorhabditis elegans ’ lifespan in response to reproductive signals

McCormick, M. A., Chen, K., Ramaswamy, P., & Kenyon, C. J. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00768.x · Cited by 135

Heat Shock Protein Accumulation Is Upregulated in a Long-Lived Mutant of Caenorhabditis elegans

Walker, G. A., White, T. M., McColl, G., Jenkins, N. L., Babich, S. L., Candido, E. P. M., Johnson, T. E., & Lithgow, G. J. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.7.b281 · Cited by 135

Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex

Ghazi, A., Henis-Korenblit, S., & Kenyon, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700638104 · Cited by 134

Catechin induced longevity in C. elegans: From key regulator genes to disposable soma

Saul, N., Pietsch, K., Menzel, R., Stürzenbaum, S. R., & Steinberg, C. E. W. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.05.005 · Cited by 133

RLE-1, an E3 Ubiquitin Ligase, Regulates C. elegans Aging by Catalyzing DAF-16 Polyubiquitination

Li, W., Gao, B., Lee, S., Bennett, K. L., & Fang, D. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.12.002 · Cited by 133

Molecular Cloning and Characterization of a New Insulin/IGF-like Peptide of the Nematode Caenorhabditis elegans

Kawano, T., Ito, Y., Ishiguro, M., Takuwa, K., Nakajima, T., & Kimura, Y. N. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2971 · Cited by 128

Oxidative Stress and Life Span Determination in the Nematode Caenorhabditis elegans

Honda, Y., & Honda, S. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02117.x · Cited by 128

TGF-ß Sma/Mab Signaling Mutations Uncouple Reproductive Aging from Somatic Aging

Luo, S., Shaw, W. M., Ashraf, J. M., & Murphy, C. T. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000789 · Cited by 127

Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.Preprint

Arasu, P., Wightman, B., & Ruvkun, G. (1991) · Genes & Development · doi:10.1101/gad.5.10.1825 · Cited by 126

Genetic Analysis of the Roles of daf28 and age-1 in Regulating Caenorhabditis elegans Dauer Formation

Malone, E. A., Inoue, T., & Thomas, J. H. (1996) · Genetics · doi:10.1093/genetics/143.3.1193 · Cited by 126

Quaternary Structure of the Insulin-Insulin Receptor Complex

Luo, R. Z.-T., Beniac, D. R., Fernandes, A., Yip, C. C., & Ottensmeyer, F. P. (1999) · Science · doi:10.1126/science.285.5430.1077 · Cited by 125

ASNA-1 Positively Regulates Insulin Secretion in C. elegans and Mammalian Cells

Kao, G., Nordenson, C., Still, M., Rönnlund, A., Tuck, S., & Naredi, P. L. J. (2007) · Cell · doi:10.1016/j.cell.2006.12.031 · Cited by 124

DamID in C. elegans reveals longevity‐associated targets of DAF‐16/FoxO

Schuster, E. F., McElwee, J. J., Tullet, J. M. A., Doonan, R., Matthijssens, F., Reece-Hoyes, J. S., Hope, I. A., Vanfleteren, J. R., Thornton, J. M., & Gems, D. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.54 · Cited by 124

C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO

Wang, Y., Oh, S. W., Deplancke, B., Luo, J., Walhout, A. J. M., & Tissenbaum, H. A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.05.005 · Cited by 122

Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator

Li, J., Ebata, A., Dong, Y., Rizki, G., Iwata, T., & Lee, S. S. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060233 · Cited by 118

The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO

Rizki, G., Iwata, T., Li, J., Riedel, C. G., Picard, C. L., Jan, M., Murphy, C. T., & Lee, S. S. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002235 · Cited by 118

Caenorhabditis elegans Integrates the Signals of Butanone and Food to Enhance Chemotaxis to Butanone

Torayama, I., Ishihara, T., & Katsura, I. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4312-06.2007 · Cited by 117

A Caenorhabditis elegans mutant lacking functional nicotinamide nucleotide transhydrogenase displays increased sensitivity to oxidative stress

Arkblad, E. L., Tuck, S., Pestov, N. B., Dmitriev, R. I., Kostina, M. B., Stenvall, J., Tranberg, M., & Rydström, J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.012 · Cited by 117

A Transcription Elongation Factor That Links Signals from the Reproductive System to Lifespan Extension in Caenorhabditis elegans

Ghazi, A., Henis‐Korenblit, S., & Kenyon, C. J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000639 · Cited by 117

Drosophila Melted Modulates FOXO and TOR Activity

Teleman, A. A., Chen, Y., & Cohen, S. M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.07.004 · Cited by 116

The Caenorhabditis elegans AMP-activated Protein Kinase AAK-2 Is Phosphorylated by LKB1 and Is Required for Resistance to Oxidative Stress and for Normal Motility and Foraging Behavior

Lee, H., Cho, J. S., Lambacher, N. J., Lee, J., Lee, S.-J., Lee, T. H., Gartner, A., & Koo, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709115200 · Cited by 114

Aging-Dependent and -Independent Modulation of Associative Learning Behavior by Insulin/Insulin-Like Growth Factor-1 Signal inCaenorhabditis elegans

Murakami, H., Bessinger, K., Hellmann, J. L., & Murakami, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3600-04.2005 · Cited by 114

Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans : rescue by the DAF-16 and HSF-1 pathways

Teixeira‐Castro, A., Ailion, M., Jalles, A., Brignull, H. R., Vilaça, J. L., Dias, N. S., Rodrigues, P., Oliveira, J. F., Neves‐Carvalho, A., Morimoto, R. I., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr203 · Cited by 114

Insulin Receptor Substrate and p55 Orthologous Adaptor Proteins Function in the Caenorhabditis elegans daf-2/Insulin-like Signaling Pathway

Wolkow, C. A., Muñoz, M. J., Riddle, D. L., & Ruvkun, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207866200 · Cited by 113

Targeting X chromosomes for repression

Meyer, B. J. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.03.008 · Cited by 110

Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans

Hsu, A., Feng, Z., Hsieh, M.-Y., & Xu, X. Z. S. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.007 · Cited by 103

Intercellular signaling of reproductive development by theC. elegansDAF-9 cytochrome P450

Mak, H. Y., & Ruvkun, G. (2004) · Development · doi:10.1242/dev.01069 · Cited by 103

GATA Transcription Factor Required for Immunity to Bacterial and Fungal Pathogens

Kerry, S. E., TeKippe, M., Gaddis, N., & Aballay, A. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000077 · Cited by 102

A steroid receptor-microRNA switch regulates life span in response to signals from the gonad

Shen, Y., Wollam, J., Magner, D., Karalay, O., & Antebi, A. (2012) · Science · doi:10.1126/science.1228967 · Cited by 102

Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles

Tazearslan, C., Huang, J., Barzilai, N., & Suh, Y. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00697.x · Cited by 101

The Somatic Reproductive Tissues of C. elegans Promote Longevity through Steroid Hormone Signaling

Yamawaki, T., Berman, J. R., Suchanek-Kavipurapu, M., McCormick, M. A., Gaglia, M. M., Lee, S., & Kenyon, C. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000468 · Cited by 100

Clustering of Genetically Defined Allele Classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 Receptor

Patel, D. S., Garza-Garcı́a, A., Nanji, M. S., McElwee, J. J., Ackerman, D., Driscoll, P. C., & Gems, D. (2008) · Genetics · doi:10.1534/genetics.107.070813 · Cited by 100

Hormonal Signal Amplification Mediates Environmental Conditions during Development and Controls an Irreversible Commitment to Adulthood

Schaedel, O. N., Gerisch, B., Antebi, A., & Sternberg, P. W. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001306 · Cited by 97

Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF‐16/FOXO

Landis, J. N., & Murphy, C. T. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22244 · Cited by 97

COP1 Functions as a FoxO1 Ubiquitin E3 Ligase to Regulate FoxO1-mediated Gene Expression

Kato, S., Ding, J., Pisck, E., Jhala, U. S., & Du, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801011200 · Cited by 96

Neuronal plasticity regulated by the insulin-like signaling pathway underlies salt chemotaxis learning inCaenorhabditis elegans

Oda, S., Tomioka, M., & Iino, Y. (2011) · Journal of Neurophysiology · doi:10.1152/jn.01029.2010 · Cited by 93

The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans

Li, J., Tewari, M., Vidal, M., & Lee, S. S. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.10.013 · Cited by 93

Insulin Signaling Plays a Dual Role in Caenorhabditis elegans Memory Acquisition and Memory Retrieval

Lin, C. H. A., Tomioka, M., Pereira, S., Sellings, L. H. L., Iino, Y., & van der Kooy, D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4636-09.2010 · Cited by 90

Regulation of signaling genes by TGFβ during entry into dauer diapause in C. elegans

Liu, T., Zimmerman, K. K., & Patterson, G. I. (2004) · BMC Developmental Biology · doi:10.1186/1471-213x-4-11 · Cited by 88

Canonical RTK-Ras-ERK signaling and related alternative pathways

Sundaram, M. V. (2013) · WormBook · doi:10.1895/wormbook.1.80.2 · Cited by 87

The Rieske oxygenase DAF‐36 functions as a cholesterol 7‐desaturase in steroidogenic pathways governing longevity

Wollam, J., Magomedova, L., Magner, D. B., Shen, Y., Rottiers, V., Motola, D., Mangelsdorf, D. J., Cummins, C. L., & Antebi, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00733.x · Cited by 85

Asymmetric Arginine Dimethylation Determines Life Span in C. elegans by Regulating Forkhead Transcription Factor DAF-16

Takahashi, Y., Daitoku, H., Hirota, K., Tamiya, H., Yokoyama, A., Kako, K., Nagashima, Y., Nakamura, A., Shimada, T., Watanabe, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.017 · Cited by 85

Identification of a DAF-16 Transcriptional Target Gene, scl-1, that Regulates Longevity and Stress Resistance in Caenorhabditis elegans

Ookuma, S., Fukuda, M., & Nishida, E. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00108-8 · Cited by 83

Caenorhabditis elegans RNA-processing Protein TDP-1 Regulates Protein Homeostasis and Life Span

Zhāng, T., Hwang, H., Hao, H., Talbot, C. C., & Wang, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.311977 · Cited by 76

A conserved PTEN/FOXO pathway regulates neuronal morphology duringC. elegansdevelopment

Christensen, R. P., de la Torre-Ubieta, L., Bonni, A., & Colón‐Ramos, D. A. (2011) · Development · doi:10.1242/dev.069062 · Cited by 74

The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans

Solari, F., Bourbon-Piffaut, A., Masse, I., Payrastre, B., Chan, A. M.-L., & Billaud, M. (2005) · Oncogene · doi:10.1038/sj.onc.1207978 · Cited by 74

Isolation and Characterization of High-Temperature-Induced Dauer Formation Mutants in Caenorhabditis elegans

Ailion, M., & Thomas, J. H. (2003) · Genetics · doi:10.1093/genetics/165.1.127 · Cited by 74

Distinct Activities of the Germline and Somatic Reproductive Tissues in the Regulation of Caenorhabditis elegans' Longevity

Yamawaki, T., Arantes-Oliveira, N., Berman, J. R., Zhang, P., & Kenyon, C. J. (2008) · Genetics · doi:10.1534/genetics.107.083253 · Cited by 73

Movement as an Index of Vitality:Comparing Wild Type and the age-1 Mutant of Caenorhabditis elegans

Duhon, S. A., & Johnson, T. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.5.b254 · Cited by 72

A divergent INS protein inCaenorhabditis elegansstructurally resembles human insulin and activates the human insulin receptorPreprint

Hua, Q. X., Nakagawa, S. H., Wilken, J., Ramos, R. R., Jia, W., Bass, J. T., & Weiss, M. A. (2003) · Genes & Development · doi:10.1101/gad.1058003 · Cited by 72

PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism

Narasimhan, S. D., Yen, K., Bansal, A., Kwon, E., Padmanabhan, S., & Tissenbaum, H. A. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001377 · Cited by 71

Effects of C aenorhabditis elegans sgk‐1mutations on lifespan, stress resistance, and DAF ‐16/ F ox O regulation

Chen, A. T., Guo, C., Dumas, K. J., Ashrafi, K., & Hu, P. J. (2013) · Aging Cell · doi:10.1111/acel.12120 · Cited by 69

C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress

Chiang, W., Tishkoff, D. X., Yang, B., Wilson‐Grady, J., Yu, X., Mazer, T., Eckersdorff, M., Gygi, S. P., Lombard, D. B., & Hsu, A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002948 · Cited by 68

Insulin Inhibition of Transcription Stimulated by the Forkhead Protein Foxo1 Is Not Solely due to Nuclear Exclusion

Tsai, W.-C., Bhattacharyya, N., Han, L., Hanover, J. A., & Rechler, M. M. (2003) · Endocrinology · doi:10.1210/en.2003-0481 · Cited by 64

Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development inCaenorhabditis elegans

Patel, D. S., Fang, L. L., Svy, D., Ruvkun, G., & Li, W. (2008) · Development · doi:10.1242/dev.016972 · Cited by 63

SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling inC. elegans

Ohkura, K., Suzuki, N., Ishihara, T., & Katsura, I. (2003) · Development · doi:10.1242/dev.00540 · Cited by 62

SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegansPreprint

Neumann‐Haefelin, E., Qi, W., Finkbeiner, E., Walz, G., Baumeister, R., & Hertweck, M. (2008) · Genes & Development · doi:10.1101/gad.478408 · Cited by 62

LET‐60 RAS modulates effects of insulin/IGF‐1 signaling on development and aging in Caenorhabditis elegans

Nanji, M. S., Hopper, N. A., & Gems, D. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00166.x · Cited by 60

Autophagy links lipid metabolism to longevity inC. elegans

Lapierre, L. R., Meléndez, A., & Hansen, M. (2012) · Autophagy · doi:10.4161/auto.8.1.18722 · Cited by 60

The protein phosphatase PP2A-B′ subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism inDrosophila

Vereshchagina, N., Ramel, M., Bitoun, E., & WILSON, C. G. (2008) · Journal of Cell Science · doi:10.1242/jcs.035220 · Cited by 59

The Caenorhabditis elegans Heterochronic Regulator LIN-14 Is a Novel Transcription Factor That Controls the Developmental Timing of Transcription from the Insulin/Insulin-Like Growth Factor Gene ins-33 by Direct DNA Binding

Hristova, M., Birse, D. E. A., Yang, H. Y., & Ambros, V. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.11059-11072.2005 · Cited by 59

The Intersection of Aging, Longevity Pathways, and Learning and Memory in C. elegans

Stein, G. M., & Murphy, C. T. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00259 · Cited by 56

EAK-7 Controls Development and Life Span by Regulating Nuclear DAF-16/FoxO Activity

Alam, H., Williams, T. W., Dumas, K. J., Guo, C., Yoshina, S., Mitani, S., & Hu, P. J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.004 · Cited by 55

Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity

Ching, T., Chiang, W., Chen, C., & Hsu, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00688.x · Cited by 51

Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms

Luo, S., & Murphy, C. T. (2010) · genesis · doi:10.1002/dvg.20694 · Cited by 51

The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional StatusPreprint

Kimura, K. D., Riddle, D. L., & Ruvkun, G. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010660 · Cited by 51

Two Membrane-Associated Tyrosine Phosphatase Homologs Potentiate C. elegans AKT-1/PKB Signaling

Hu, P. J., Xu, J., & Ruvkun, G. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0020099 · Cited by 51

drr‐2 encodes an eIF4H that acts downstream of TOR in diet‐restriction‐induced longevity of C. elegans

Ching, T., Paal, A. B., Mehta, A., Zhong, L., & Hsu, A. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00580.x · Cited by 50

PTEN Negatively Regulates MAPK Signaling during Caenorhabditis elegans Vulval Development

Nakdimon, I., Walser, M., Fröhli, E., & Hajnal, A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002881 · Cited by 49

Pl3-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans☆

Babar, P., Adamson, C., Walker, G. A., et al. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00094-9 · Cited by 46

Effects of Sex and Insulin/Insulin-Like Growth Factor-1 Signaling on Performance in an Associative Learning Paradigm in Caenorhabditis elegans

Vellai, T., McCulloch, D., Gems, D., & Kovács, A. (2006) · Genetics · doi:10.1534/genetics.106.061499 · Cited by 46

Hyperactive Neuroendocrine Secretion Causes Size, Feeding, and Metabolic Defects of C. elegans Bardet-Biedl Syndrome Mutants

Lee, B. H., Liu, J., Wong, D., Srinivasan, S., & Ashrafi, K. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001219 · Cited by 43

Environmental and Genetic Preconditioning for Long-Term Anoxia Responses Requires AMPK in Caenorhabditis elegans

LaRue, B., & Padilla, P. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016790 · Cited by 43

Insulin/Insulin-Like Growth Factor Signaling Controls Non-Dauer Developmental Speed in the Nematode Caenorhabditis elegans

Ruaud, A., Katic, I., & Bessereau, J. (2010) · Genetics · doi:10.1534/genetics.110.123323 · Cited by 40

Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans

Karp, X., & Greenwald, I. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222377110 · Cited by 39

Loss of SMEK, a Novel, Conserved Protein, Suppresses mek1 Null Cell Polarity, Chemotaxis, and Gene Expression Defects

Mendoza, M. C., Du, F., Iranfar, N., Tang, N., Ma, H., Loomis, W. F., & Firtel, R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7839-7853.2005 · Cited by 38

Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan

Dumas, K. J., Guo, C., Wang, X., Burkhart, K. B., Adams, E. J., Alam, H., & Hu, P. J. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.02.022 · Cited by 38

Regulation of Caenorhabditis elegans RNA Interference by the daf-2 Insulin Stress and Longevity Signaling PathwayPreprint

WANG, D., & Ruvkun, G. (2004) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2004.69.429 · Cited by 38

Insulin/IGF-1 receptor signaling enhances biosynthetic activity and fat mobilization in the initial phase of starvation in adult male C. elegans.

Tan, K.-T., Luo, S.-C., Ho, W.-Z., & Lee, Y.-H. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.019 · Cited by 37

Opposed growth factor signals control protein degradation in muscles of Caenorhabditis elegans

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Nomarski images for learning the anatomy, with tips for mosaic analysis

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