The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Second AKT: The rise of SGK in cancer signalling
Abstract
The serum and glucocorticoid kinase (SGK) family of serine/threonine kinases consists of three isoforms, SGK-1, SGK-2 and SGK-3. This family of kinases is highly homologous to the AKT kinase family, sharing similar upstream activators and downstream targets. SGKs have been implicated in the regulation of cell growth, proliferation, survival and migration: cellular processes that are dysregulated in cancer. Furthermore, SGKs lie downstream of phosphoinositide-3-kinase (PI3Kinase) signalling and interact at various levels with RAS/RAF/ERK signalling, two pathways that are involved in promoting tumorigenesis. Recent evidence suggests that mutant PI3Kinase can induce tumorigenesis through an AKT-independent but SGK3-dependent mechanism, thus implicating SGKs as potential players in malignant transformation. Here, we will review the current state of knowledge on the regulation of the SGKs and their role in normal cell physiology and transformation with a particular focus on SGK3.
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Cites
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Cited by
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Insulin/insulin-like growth factor signaling in C. elegans
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SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells
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Dattilo, V., Amato, R., Perrotti, N., & Gennarelli, M. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00826 · Cited by 49
O'Keeffe, B. A., Cilia, S., Maiyar, A. C., Vaysberg, M., & Firestone, G. L. (2013) · Biochimie · doi:10.1016/j.biochi.2013.01.019 · Cited by 27
Metadata
- Authors
- Bruhn, M. A., Pearson, R. B., Hannan, R. D., & Sheppard, K. E.
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 2010-10-05
- Volume
- 28
- Issue
- 6
- Pages
- 394-408
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W1989408768
- Cited by
- 160
- References
- 17
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bruhn, M. A., Pearson, R. B., Hannan, R. D., & Sheppard, K. E. (2010). Second AKT: The rise of SGK in cancer signalling. Growth Factors. https://doi.org/10.3109/08977194.2010.518616
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