The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A steroid receptor-microRNA switch regulates life span in response to signals from the gonad
Abstract
Gonads and Life Span: Animals develop through successive life stages and have life spans that are determined by their genes and the environment. Yet how the molecular circuitry underlying life-stage structure relates to longevity is poorly understood. Shen et al. (p. 1472 ) now show that components of a steroid receptor-microRNA switch used for Caenorhabditis elegans developmental timing is co-opted to regulate adult longevity in response to signals from the reproductive system. Thus, the gonad can be coupled to metazoan life span via a developmental clock.
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“Gain- and loss-of-function studies have confirmed the capacity of several miRNAs to modulate longevity in Drosophila melanogaster and C. elegans (Liu et al., 2012; Shen et al., 2012; Smith-Vikos and Slack, 2012).”
From The Hallmarks of Aging (2013) · cites this paper as Shen et al., 2012
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Molecular physiology of bile acid signaling in health, disease, and aging
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Metadata
- Authors
- Shen, Y., Wollam, J., Magner, D., Karalay, O., & Antebi, A.
- Affiliations
- Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, D-50931 Cologne, Germany.
- Venue
- Science
- Published
- 2012-12-14
- Volume
- 338
- Issue
- 6113
- Pages
- 1472-1476
- ISSN
- 0036-8075
- 1095-9203
- PMC
- PMC3909774
- Cited by
- 102
- References
- 2
- Language
- en
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