Cited by 143Muscle Physiology and DisordersCardiomyopathy and Myosin StudiesDevelopmental Biology and Gene Regulation

Sarcomere assembly in C. elegans muscle

Open access
Moerman, Donald·2006·WormBook

Abstract

Sarcomeres within body wall muscle in C. elegans include attachments to the sarcolemma that are remarkably similar in structure to vertebrate adhesion complexes. Crucial early steps in muscle sarcomere assembly, a highly orchestrated affair involving many proteins, involve the assembly of these sarcomere attachments. The steps involved in initiating the correct placement of these attachments and other sarcomere substructures are poorly understood. Using mutants in C. elegans we are attempting to dissect the various steps in this process. We review what has been discovered to date and present a model of sarcomere assembly that initiates at the plasma membrane and involves proteins within muscle, the hypodermis and within the extracellular matrix.

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Crossref · 10.1895/wormbook.1.81.1

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55 of 55 references verified0 citation errors · 0 not checkable

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Authors
Moerman, D.
Affiliations
University of British Columbia (CA)
Corresponding author
Moerman, Donald
Venue
WormBook
Publisher
WormBook
Published
2006
Pages
1-16
ISSN
1551-8507 (ISSN-L)
OpenAlex
W2001878184
Cited by
143
References
57
Citations by year
2025: 2 · 2024: 6 · 2023: 12 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 10 · 2016: 2 · 2015: 8 · 2014: 13 · 2013: 7 · 2012: 12
FWCI
0.72
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • WormBook (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • Heart and Stroke Foundation of Canada
  • National Institutes of Health
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD38646)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
sarcomere assembly, Caenorhabditis elegans, body wall muscle, sarcolemma, adhesion complexes, subcutaneous tissue, extracellular matrix, plasma membrane, myogenesis
MeSH terms
Animals, Muscles, Sarcomeres, Caenorhabditis elegans

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