The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Periodontal Disease and Preterm Birth: Results of a Pilot Intervention Study
Abstract
Background: Previous case‐control and prospective studies have shown an association between the presence of periodontitis and the risk of preterm birth (PTB). The goal of this pilot trial was to determine the feasibility of conducting a trial to determine whether treatment of periodontitis reduces the risk of spontaneous preterm birth (SPTB). Methods: Three hundred sixty‐six (366) women with periodontitis between 21 and 25 weeks' gestation were recruited and randomized to one of three treatment groups with stratifi‐ cation on the following two factors: 1) previous SPTB at <35 weeks and 2) body mass index <19.8 or bacterial vaginosis as assessed by gram stain. The treatment groups consisted of: 1) dental prophylaxis plus placebo capsule; 2) scaling and root planing (SRP) plus placebo capsule; and 3) SRP plus metronidazole capsule (250 mg t.i.d. for one week). An additional group of 723 pregnant women meeting the same criteria for periodontitis and enrolled in a prospective study served as an untreated reference group. Results: The rate of PTB at <35 weeks was 4.9% in the prophylaxis group, compared to 3.3% in the SRP plus metronidazole group and 0.8% in the SRP plus placebo group (P = 0.75 and 0.12, respectively). The rate of PTB at <35 weeks was 6.3% in the reference group. Conclusions: This trial indicates that performing SRP in pregnant women with periodontitis may reduce PTB in this population. Adjunctive metronidazole therapy did not improve pregnancy outcome. Larger trials will be needed to achieve statistical significance, especially at less than 35 weeks gestational age. J Periodontol 2003;74:1214‐1218.
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Cites
Intrauterine infection and preterm delivery
Goldenberg, R. L., Hauth, J. C., & Andrews, W. W. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422007 · Cited by 2,548
Self-citationPeriodontal infection as a possible risk factor for preterm low birth weight
Offenbacher, S., Katz, V., Fertik, G., Collins, J., Boyd, D., Maynor, G., McKaig, R., & Beck, J. (1996) · Journal of Periodontology · doi:10.1902/jop.1996.67.10s.1103 · Cited by 1,455
A review of premature birth and subclinical infection
Gibbs, R. S., Romero, R., Hillier, S. L., Eschenbach, D. A., & Sweet, R. L. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(92)91628-n · Cited by 891
Metronidazole to Prevent Preterm Delivery in Pregnant Women with Asymptomatic Bacterial Vaginosis
Carey, J. C., Klebanoff, M. A., Hauth, J. C., Hillier, S. L., Thom, E. A., Ernest, J. M., Heine, R. P., Nugent, R. P., Fischer, M. L., Leveno, K. J., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002243420802 · Cited by 673
Self-citationPotential Pathogenic Mechanisms of Periodontitis‐Associated Pregnancy Complications
Offenbacher, S., Jared, H. L., O'Reilly, P. G., Wells, S. R., Salvi, G. E., Lawrence, H. P., Socransky, S. S., & Beck, J. D. (1998) · Annals of Periodontology · doi:10.1902/annals.1998.3.1.233 · Cited by 574
Offenbacher, S., Lieff, S., Boggess, K. A., Murtha, A. P., Madianos, P. N., Champagne, C. M. E., McKaig, R. G., Jared, H. L., Mauriello, S. M., Auten, R. L., et al. (2001) · Annals of Periodontology · doi:10.1902/annals.2001.6.1.164 · Cited by 489
Periodontal infection and preterm birth
JEFFCOAT, M. K., GEURS, N. C., REDDY, M. S., CLIVER, S. P., GOLDENBERG, R. L., & HAUTH, J. C. (2001) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2001.0299 · Cited by 476
Self-citationKlebanoff, M. A., Carey, J. C., Hauth, J. C., Hillier, S. L., Nugent, R. P., Thom, E. A., Ernest, J. M., Heine, R. P., Wapner, R. J., Trout, W., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa003329 · Cited by 461
Self-citationA Quantitative Review of Mortality and Developmental Disability in Extremely Premature Newborns
Lorenz, J. M., Wooliever, D. E., Jetton, J. R., & Paneth, N. (1998) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.152.5.425 · Cited by 320
Maternal Periodontal Disease and Preterm Low Birthweight: Case-Control Study
Davenport, E. S., Williams, C. E. C. S., Sterne, J. A. C., Murad, S., Sivapathasundram, V., & Curtis, M. A. (2002) · Journal of Dental Research · doi:10.1177/154405910208100505 · Cited by 304
Cited by
Kinane, D. F., Stathopoulou, P. G., & Papapanou, P. N. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.38 · Cited by 2,724
Periodontal disease and adverse pregnancy outcomes: a systematic review
Xiong, X., Buekens, P., Fraser, W., Beck, J., & Offenbacher, S. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2005.00827.x · Cited by 508
Leitich, H., & Kiss, H. (2007) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2006.12.005 · Cited by 342
Low‐Grade Inflammation in Chronic Infectious Diseases: Paradigm of Periodontal Infections
MOUTSOPOULOS, N. M., & MADIANOS, P. N. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1366.032 · Cited by 297
Periodontal disease and upper genital tract inflammation in early spontaneous preterm birth
Goepfert, A. R., Jeffcoat, M. K., Andrews, W. W., Faye-Petersen, O., Cliver, S. P., Goldenberg, R. L., & Hauth, J. C. (2004) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000139836.47777.6d · Cited by 213
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Metadata
- Authors
- Jeffcoat, M. K., Hauth, J. C., Geurs, N. C., Reddy, M. S., Cliver, S. P., Hodgkins, P. M., & Goldenberg, R. L.
- Venue
- Journal of Periodontology
- Publisher
- Wiley
- Published
- 2003-08
- Volume
- 74
- Issue
- 8
- Pages
- 1214-1218
- ISSN
- 0022-3492 (ISSN-L)
- 1943-3670
- OpenAlex
- W2033056039
- Cited by
- 379
- References
- 16
- FWCI
- 28.58
- Type
- journal article
- Language
- en
- Open access
- closed
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