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Informational Paper: Drug‐Associated Gingival Enlargement
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This informational paper is intended to provide the dental profession with an overview of existing evidence regarding the prevalence, risk factors, pathogenesis, and clinical management of drug‐associated gingival enlargement. J Periodontol 2004;75:1424‐1431.
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“The severity of overgrowth varies among different classes of drugs, with phenytoin having the highest incidence of reported cases, whereas cases associated with sodium valproate are minimal.”
From Sodium Valproate-Induced Gingival Enlargement in a Pediatric Patient: A Case Report With Surgical Intervention (2025) · cites this paper as [3]
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“The risk factors and causative agents that increase the abnormal growth of gingiva include age, genetic factors, drug doses, plaque inflammation, and bacteria [3,9].”
From Sodium Valproate-Induced Gingival Enlargement in a Pediatric Patient: A Case Report With Surgical Intervention (2025) · cites this paper as [3]
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“The documented cases of sodium valproate are minimal.”
From Sodium Valproate-Induced Gingival Enlargement in a Pediatric Patient: A Case Report With Surgical Intervention (2025) · cites this paper as [3]
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Citations
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Rao, K., Priya, N., Sheethal, H., Umadevi, H., Smitha, T. V., & Srinivasan, S. (2020) · Journal of Health Sciences & Research · doi:10.5005/jp-journals-10042-1093
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Oral manifestations of pharmacological treatment of systemic diseases
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The basics and clinical management of calcium channel blocker-induced gingival overgrowth
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PERIODONTAL TREATMENT OF GINGIVAL OVERGROWTH DUE TO AMLODIPINE USE: CASE SERIES
Şayan, P. (2022) · European Annals of Dental Sciences · doi:10.52037/eads.2022.27
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Amlodipine-Induced Gingival Enlargement – A Case Report
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Amlodipin Kullanımına Bağlı Diş Eti Büyümelerinin Cerrahisiz Periodontal Tedavisi: 2 Olgu Sunumu
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“These include, for example, the simultaneous use of ciclosporin and azathioprine, as well as ciclosporin and calcium channel blockers such as amlodipine (Dongari-Bagtzoglou 2004).”
The Impact of Continuous Dialysis on Oral Health: A Comprehensive Review
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Metadata
- Authors
- Dongari‐Bagtzoglou, A. I.
- Corresponding author
- Anna I. Dongari‐Bagtzoglou
- Venue
- Journal of Periodontology
- Publisher
- Wiley
- Published
- 2004-10
- Volume
- 75
- Issue
- 10
- Pages
- 1424-1431
- ISSN
- 0022-3492 (ISSN-L)
- 1943-3670
- OpenAlex
- W46952399
- Cited by
- 201
- References
- 62
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 13 · 2023: 6 · 2022: 9 · 2021: 23 · 2020: 12 · 2019: 15 · 2018: 6 · 2017: 12 · 2016: 6 · 2015: 14 · 2014: 13 · 2013: 10 · 2012: 9
- FWCI
- 16.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Periodontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral and gingival health research
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
- Keywords
- gingival hyperplasia, prevalence, risk factors, pathogenesis, clinical management, antiepileptic drugs, immunosuppressants, antithrombotic agents
- MeSH terms
- Anticonvulsants, Calcium Channel Blockers, Humans, Immunosuppressive Agents, Risk Factors, Gingival Overgrowth
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