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Cited by 121Oral microbiology and periodontitis researchBone Metabolism and DiseasesPeriodontal Regeneration and Treatments

Cytokines and Bone‐Related Factors in Systemically Healthy Patients With Chronic Periodontitis and Patients With Type 2 Diabetes and Chronic Periodontitis

Vieira Ribeiro, Fernanda, de Mendonça, Adriana Cutrim, Santos, Vanessa Renata, Bastos, Marta Ferreira, Figueiredo, Luciene Cristina, Duarte, Poliana Mendes·2011·Journal of Periodontology
DOI 10.1902/jop.2011.100643
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Abstract

Background: This study compares the levels of cytokines and bone‐related factors in the gingival crevicular fluid (GCF) of systemically healthy patients with chronic periodontitis (CP); and better‐controlled, and poorly controlled patients with type 2 diabetes and CP. Methods: Thirty‐seven patients with type 2 diabetes and CP and 20 systemically healthy patients with CP were enrolled in this study. The patients with diabetes mellitus were categorized as better‐controlled (n = 17; HbA 1c levels ≤8%) or poorly controlled (n = 20; glycated hemoglobin values >8%). Levels of tumor necrosis factor‐α, interleukin (IL)‐4, interferon (IFN)‐γ, IL‐23, IL‐17, soluble receptor activator of nuclear factor‐kappa B ligand (sRANKL), and osteoprotegerin (OPG) in GCF of diseased sites were analyzed by enzyme‐linked immunosorbent assay. Results: Type 2 diabetes mellitus, as a whole, upregulates the levels of OPG, sRANKL, IFN‐γ, IL‐17, and IL‐23 and downregulates the production of IL‐4 in sites with CP (P <0.05). Better‐controlled individuals exhibited the highest levels of IFN‐γ, whereas poorly controlled patients presented the highest levels of IL‐17 (P <0.05). There were no differences in the levels of tumor necrosis factor‐α, OPG, and IL‐23 among systemically healthy, better‐controlled, and poorly controlled patients with diabetes (P >0.05). Conclusions: Increased levels of proinflammatory cytokines and RANKL were observed in the GCF of patients with type 2 diabetes with CP, compared to patients without diabetes. In addition, poor or good glycemic status seems to modulate osteo‐immunoinflammatory mediators in a different manner.

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  • Type 2 diabetes mellitus, and the hyperglycemia related to this disease, are associated with increased risk of periodontitis as a result of the vascular complications of diabetes and increased levels of pro-inflammatory molecules.

    “Type 2 diabetes mellitus, and the hyperglycemia related to this disease, are associated with increased risk of periodontitis as a result of the vascular complications of diabetes and increased levels of pro‐inflammatory molecules.216, 217, 218”

    From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [217]

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Authors
Vieira Ribeiro, F., de Mendonça, A. C., Santos, V. R., Bastos, M. F., Figueiredo, L. C., & Duarte, P. M.
Affiliations
Guarulhos University (BR)
Corresponding author
Duarte, Poliana Mendes
ORCID
Venue
Journal of Periodontology
Publisher
Wiley
Published
2011-08
Volume
82
Issue
8
Pages
1187-1196
ISSN
  • 0022-3492 (ISSN-L)
  • 1943-3670
DOI
10.1902/jop.2011.100643
OpenAlex
W1991121464
Cited by
121
References
50
Citations by year
2026: 3 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 10 · 2021: 6 · 2020: 12 · 2019: 9 · 2018: 7 · 2017: 5 · 2016: 12 · 2015: 10 · 2014: 8 · 2013: 13 · 2012: 5
FWCI
11.46
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Periodontology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fundação de Amparo à Pesquisa do Estado de São Paulo
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
chronic periodontitis, type 2 diabetes, gingival crevicular fluid, cytokines, RANKL, osteoprotegerin, IL-17, IL-23, interferon-gamma, IL-4, TNF-α, glycemic control, HbA1c, periodontal inflammation, osteoimmunology
MeSH terms
Adult, Analysis of Variance, Blood Glucose, Diabetes Mellitus, Type 2, Female, Gingival Crevicular Fluid, Humans, Male, Middle Aged, Reference Values, Cohort Studies, Case-Control Studies, Cytokines, Statistics, Nonparametric, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Chronic Periodontitis

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