Effect of acute mid-intensity treadmill exercise on the androgen hormone level and uncoupling protein-1 expression in brown fat tissue of mouse
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PURPOSE: Brown adipose tissue (BAT) plays an important role in metabolizing different substances, including androgens. The aim of this study was to determine whether a single bout of aerobic exercise would increase the androgen hormone concentration in mouse BAT and whether its increase was associated with uncoupling protein-1 (UCP-1), protein kinase A (PKA)-related mechanism in BAT. METHODS: Twenty, 9-week-old ICR adult male micewere randomly divided into three groups: Control (n=6, CON), Exercise (n=7, EX), and Exercise + SRD5A1A2 inhibitor (n=7, EXIN). SRD5A1A2 is an enzyme needed when free testosterone is metabolized to dihydrotestosterone (DHT). SRD5A1A2 was administered intraperitoneally in the EXIN group, while the CON and EX groups were treated with the vehicle only. One hour later, exercise was performed at 60-70% V̇O2max for 30minutes. The levels of testosterone and DHT in BAT were determined by ELISA, and UCP-1 mRNA level was examined by RT-PCR. UCP-1 and PKA protein levels were determined by western blotting. RESULTS: After a single period of exercise, testosterone and DHT concentrations in BAT were significantly higher in EX than those in CON, and lower in EXIN than those in EX. The ratio of phosphorylated PKA to total PKA in BAT was significantly higher in EX than that in CON, and lower in EXIN than that in EX. UCP-1 levels in BAT were not different in the three groups. CONCLUSION: Aerobic exercise increased bioactive androgen hormone levels in BAT in association with the increase in phosphorylated PKA levels. In contrast, 30minutes of treadmill exercise did not affect UCP-1 expression.
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Acute physical exercise leads to an increase in BAT UCP-1 protein expression in HFD-treated Swiss mice and ICR mice.
“As an example, acute physical exercise leads to an increase in BAT UCP-1 protein expression in HFD-treated (High Fat Diet) Swiss mice [194] and ICR (Institute of Cancer Research) mice [195].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [195]
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Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases
Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476 · see citing works
- Authors
- Kim, N., Kim, J., Yoo, C., Lim, K., Akimoto, T., & Park, J.
- Affiliations
- Konkuk University (KR)
- Waseda University (JP)
- Korea University (KR)
- Corresponding author
- Park, Jonghoon
- Venue
- Journal of Exercise Nutrition & Biochemistry
- Publisher
- Korea Society for Exercise Nutrition
- Published
- 2018-03-30
- Volume
- 22
- Issue
- 1
- Pages
- 15-21
- ISSN
- 2233-6834 (ISSN-L)
- 2233-6842
- PMC
- PMC5909077
- OpenAlex
- W2800496612
- Cited by
- 7
- References
- 29
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Physical Activity and Nutrition (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (NRF-2014S1A5A8019709)
- Konkuk University
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- brown adipose tissue, androgens, testosterone, dihydrotestosterone, aerobic exercise, treadmill exercise, UCP1, protein kinase A, androgen metabolism
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