Androgen Receptor Null Male Mice Develop Late-Onset Obesity Caused by Decreased Energy Expenditure and Lipolytic Activity but Show Normal Insulin Sensitivity With High Adiponectin Secretion
Open accessAbstract
Androgen receptor (AR) null male mice (ARL−/Y) revealed late-onset obesity, which was confirmed by computed tomography–based body composition analysis. ARL−/Y mice were euphagic compared with the wild-type male (ARX/Y) controls, but they were also less dynamic and consumed less oxygen. Transcript profiling indicated that ARL−/Y mice had lower transcripts for the thermogenetic uncoupling protein 1, which was subsequently found to be ligand-dependently activated by AR. We also found enhanced secretion of adiponectin, which is insulin sensitizing, from adipose tissue and a relatively lower expression of peroxisome proliferator–activated receptor-γ in white adipose tissue in comparison to ARX/Y mice. Both factors might explain why the overall insulin sensitivity of ARL−/Y mice remained intact, despite their apparent obesity. The results revealed that AR plays important roles in male metabolism by affecting the energy balance, and it is negative to both adiposity and insulin sensitivity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
Obesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398 · see citing works
Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076 · see citing works
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,074 · see citing works
Towards a molecular understanding of adaptive thermogenesis
Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630 · see citing works
PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance
Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., 杉山, 拓., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80210-5 · Cited by 1,342 · see citing works
Increased adipose tissue in male and female estrogen receptor-α knockout mice
Heine, P. A., Taylor, J. A., Iwamoto, G. A., Lubahn, D. B., & Cooke, P. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12729 · Cited by 1,282 · see citing works
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14120 · Cited by 935 · see citing works
Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial
Sih, R., Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., & Ross, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3988 · Cited by 920 · see citing works
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., Matsui, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209033200 · Cited by 911 · see citing works
Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
Nishizawa, H., Shimomura, I., Kishida, K., Maeda, N., Kuriyama, H., Nagaretani, H., Matsuda, M., Kondo, H., Furuyama, N., Kihara, S., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2734 · Cited by 837 · cited 1× · see citing works
“This supports a previous suggestion that testosterone inhibits adiponectin secretion from adipocytes (35,36).”
BackgroundβAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance
Bachman, E. S., Dhillon, H., Zhang, C.-Y., Cinti, S., Bianco, A. C., Kobilka, B. K., & Lowell, B. B. (2002) · Science · doi:10.1126/science.1073160 · Cited by 782 · see citing works
Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity
Jones, M. E. E., Thorburn, A. W., Britt, K. L., Hewitt, K. N., Wreford, N. G., Proietto, J., Oz, O. K., Leury, B. J., Robertson, K. M., Yao, S., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12735 · Cited by 729 · see citing works
Adipocytokines and Insulin Resistance
Pittas, A. G., Joseph, N. A., & Greenberg, A. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031005 · Cited by 515 · see citing works
Andropause: clinical implications of the decline in serum testosterone levels with aging in men
Matsumoto, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.2.m76 · Cited by 490 · see citing works
Kyle, U., Genton, L., Hans, D., Karsegard, L., Slosman, D., & Pichard, C. (2001) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601198 · Cited by 442 · see citing works
Mauras, N., Hayes, V. Y., Welch, S., Rini, A., Helgeson, K., Dokler, M. L., Veldhuis, J. D., & Urban, R. J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4892 · Cited by 409 · see citing works
Wang, C. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2839 · Cited by 359 · see citing works
Suppressive function of androgen receptor in bone resorption
Kawano, H., Sato, T., Yamada, T., Μatsumoto, T., Sekine, K., Watanabe, T., Nakamura, T., Fukuda, T., Yoshimura, K., Yoshizawa, T., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533500100 · Cited by 318 · see citing works
Self-citationBrain masculinization requires androgen receptor function
Sato, T., Matsumoto, T., Kawano, H., Watanabe, T., Uematsu, Y., Sekine, K., Fukuda, T., Aihara, K.-I., Krust, A., Yamada, T., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305303101 · Cited by 303 · see citing works
Self-citationInvited Review: Uncoupling proteins and thermoregulation
Argyropoulos, G., & Harper, M. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00994.2001 · Cited by 231 · see citing works
The Effects of Androgens on the Regulation of Lipolysis in Adipose Precursor Cells
Xu, X., Pergola, G. D., & Björntorp, P. A. (1990) · Endocrinology · doi:10.1210/endo-126-2-1229 · Cited by 202 · see citing works
Late onset of obesity in male androgen receptor-deficient (AR KO) mice
Sato, T., Μatsumoto, T., Yamada, T., Watanabe, T., Kawano, H., & Kato, S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02774-2 · Cited by 196 · see citing works
Self-citationSerum adiponectin levels in hypogonadal males: influence of testosterone replacement therapy
Lanfranco, F., Zitzmann, M., Simoni, M., & Nieschlag, E. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02007.x · Cited by 178 · see citing works
Insulin Resistance in Nonobese Patients with Polycystic Ovary Syndrome
Toprak, S., Yönem, A., Çakır, B., Güler, S., Azal, Ö., Özata, M., & Çorakçı, A. (2001) · Hormone Research in Paediatrics · doi:10.1159/000049972 · Cited by 152 · see citing works
Vermeulen, A. (2000) · Maturitas · doi:10.1016/s0378-5122(99)00075-4 · Cited by 147 · see citing works
Cellular and Molecular Characterization of the Adipose Phenotype of the Aromatase-Deficient Mouse
Misso, M. L., Murata, Y., Boon, W. C., Jones, M. E. E., Britt, K. L., & Simpson, E. R. (2003) · Endocrinology · doi:10.1210/en.2002-221123 · Cited by 139 · see citing works
The influence of androgens on insulin resistance
Shoupe, D., & Løbo, R. A. (1984) · Fertility and Sterility · doi:10.1016/s0015-0282(16)47716-2 · Cited by 138 · see citing works
Fan, W., Yanase, T., Morinaga, H., Mu, Y.-M., Nomura, M., Okabe, T., Goto, K., Harada, N., & Nawata, H. (2004) · Endocrinology · doi:10.1210/en.2004-1046 · Cited by 105 · see citing works
Self-citationUsing quantitative CT to assess adipose distribution in adult men with acquired hypogonadism.
Katznelson, L. J., Rosenthal, D. I., Rosol, M. S., Anderson, E. J., Hayden, D. L., Schoenfeld, D., & Klibanski, A. (1998) · American Journal of Roentgenology · doi:10.2214/ajr.170.2.9456958 · Cited by 95 · see citing works
Neurochemical identity of neurones expressing oestrogen and androgen receptors in sheep hypothalamus
Herbison, A. E. (2019) · Bioscientifica Proceedings · doi:10.1530/biosciprocs.3.021 · Cited by 78 · see citing works
Rolf, C., von Eckardstein, S., Koken, U. H., & Nieschlag, E. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460505 · Cited by 72 · see citing works
Ibáñez, L., Valls, C., Cabré, S., & de Zegher, F. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0047 · Cited by 61 · see citing works
Poletti, A., & Martini, L. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00150-2 · Cited by 60 · see citing works
Fan, W., Yanase, T., Wu, Y., Kawate, H., Saitoh, M., Oba, K., Nomura, M., Okabe, T., Goto, K., Yanagisawa, J., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0110 · Cited by 58 · see citing works
Self-citationHolte, J. (1998) · Journal of Endocrinological Investigation · doi:10.1007/bf03350784 · Cited by 52 · see citing works
Androgen receptor gene repeats and indices of obesity in older adults
Gustafson, D., Wen, M.-M., & Koppanati, B. M. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802191 · Cited by 48 · see citing works
Influence of Growth Hormone and Androgens on Body Composition in Adults
Jørgensen, J. O. L., Vahl, N., Hansen, T. B., Fisker, S., Hagen, C., & Christiansen, J. S. (2008) · Hormone Research · doi:10.1159/000184766 · Cited by 34 · see citing works
Regulation of somatostatin and growth hormone-releasing hormone gene expression in the rat brain
Zeitler, P. S., Vician, L. J., Chowen, J. A., Argente, J., Tannenbaum, G. S., Clifton, D. K., & Steiner, R. A. (1990) · Metabolism · doi:10.1016/0026-0495(90)90209-u · Cited by 29 · see citing works
Another role highlighted for estrogens in the male: Sexual behavior
Simpson, E. R., & Davis, S. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.011526097 · Cited by 27 · see citing works
Hasegawa, O., Sugihara, H., Minami, S., & Wakabayashi, I. (1992) · Peptides · doi:10.1016/0196-9781(92)90077-g · Cited by 26 · see citing works
Avogaro, A., Nosadini, R., Doria, A., Tremolada, C., Baccaglini, U., Ambrosio, F., Merkel, C., Nosadini, A., Trevisan, R., & Fioretto, P. (1990) · Metabolism · doi:10.1016/0026-0495(90)90146-4 · Cited by 21 · see citing works
Effect of alloxan diabetes on kidney growth in intact and castrated mice
Broulik, P. D., & Schreiber, V. (1982) · European Journal of Endocrinology · doi:10.1530/acta.0.0990109 · Cited by 7 · see citing works
Avdalović, N., & Bates, M. (1975) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(75)90097-0 · Cited by 6 · see citing works
Flagged first, then by citations
2 of the 45 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Human Obesity Gene Map: The 2005 Update
Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119 · see citing works
Androgen Receptor Structure, Function and Biology: From Bench to Bedside.
(2016) · Europe PMC (PubMed Central) · Cited by 623 · see citing works
Sex differences in the physiology of eating
Asarian, L., & Geary, N. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2012 · Cited by 513 · see citing works
Kelly, D. M., & Jones, T. H. (2015) · Obesity Reviews · doi:10.1111/obr.12282 · Cited by 487 · see citing works
Regulation of adipocyte lipolysis
Frühbeck, G., Méndez-Giménez, L., Fernández-Formoso, J., Fernández, S., & Rodríguez, A. (2014) · Nutrition research reviews · doi:10.1017/s095442241400002x · Cited by 380 · see citing works
Lu, N. Z., Wardell, S. E., Burnstein, K. L., DeFranco, D. B., Fuller, P. J., Giguère, V., Hochberg, R. B., McKay, L. I., Renoir, J., Weigel, N. L., et al. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.9 · Cited by 425 · see citing works
Sex-Specific Differences in Lipid and Glucose Metabolism
Varlamov, O., Bethea, C. L., & Roberts, C. T. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00241 · Cited by 406 · see citing works
Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism
Macotela, Y., Boucher, J., Tran, T. T., & Kahn, C. R. (2009) · Diabetes · doi:10.2337/db08-1054 · Cited by 401 · see citing works
Gender and Sex Differences in Adipose Tissue
Chang, E. T., Varghese, M., & Singer, K. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1031-3 · Cited by 392 · see citing works
Low Testosterone in Men with Type 2 Diabetes: Significance and Treatment
Grossmann, M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0118 · Cited by 350 · see citing works
Mauvais-Jarvis, F. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.10.002 · Cited by 335 · see citing works
The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice
Chen, X., McClusky, R., Chen, J., Beaven, S. W., Tontonoz, P., Arnold, A. P., & Reue, K. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002709 · Cited by 326 · see citing works
Androgens and body fat distribution
Blouin, K., Boivin, A., & Tchernof, A. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.09.001 · Cited by 306 · see citing works
Lowered testosterone in male obesity: Mechanisms, morbidity and management
Grossmann, M., Tang Fui, M., & Dupuis, P. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122365 · Cited by 293 · see citing works
Genetic Basis for Sex Differences in Obesity and Lipid Metabolism
Link, J. C., & Reue, K. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064827 · Cited by 293 · see citing works
The role of androgens in metabolism, obesity, and diabetes in males and females
Navarro, G., Allard, C., Xu, W., & Mauvais‐Jarvis, F. (2015) · Obesity · doi:10.1002/oby.21033 · Cited by 289 · see citing works
Fan, W., Yanase, T., Morinaga, H., Gondo, S., Okabe, T., Nomura, M., Komatsu, T., Morohashi, K.-I., Hayes, T. B., Takayanagi, R., et al. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9758 · Cited by 278 · see citing works
Self-citationC57BL/6J and A/J Mice Fed a High‐Fat Diet Delineate Components of Metabolic Syndrome
Gallou‐Kabani, C., Vigé, A., Gross, M., Rabès, J., Boileau, C., Larue‐Achagiotis, C., Tomé, D., Jaïs, J., & Junien, C. (2007) · Obesity · doi:10.1038/oby.2007.238 · Cited by 234 · see citing works
Osteocalcin and its endocrine functions
Mizokami, A., Kawakubo‐Yasukochi, T., & Hirata, M. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.02.001 · Cited by 209 · see citing works
Hypothalamic control of energy expenditure and thermogenesis
Tran, L. T., Park, S., Kim, S. K., Lee, J. S., Kim, K. W., & Kwon, O. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00741-z · Cited by 208 · see citing works
Raskin, K., de Gendt, K., Duittoz, A., Liere, P., Verhoeven, G., Tronche, F., & Mhaouty-Kodja, S. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0296-09.2009 · Cited by 218 · see citing works
Obesity I: Overview and molecular and biochemical mechanisms
Lustig, R. H., Collier, D., Kassotis, C., Roepke, T. A., Kim, M. J., Blanc, E., Barouki, R., Bansal, A., Cave, M. C., Chatterjee, S., et al. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115012 · Cited by 203 · see citing works
The role of androgen and its related signals in PCOS
Ye, W., Xie, T., Song, Y., & Zhou, L. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16205 · Cited by 191 · see citing works
Fan, W., Yanase, T., Morinaga, H., Okabe, T., Nomura, M., Daitoku, H., Fukamizu, A., Kato, S., Takayanagi, R., & Nawata, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610447200 · Cited by 189 · see citing works
Self-citationFrailty in elderly diabetes patients
Yanase, T., Yanagita, I., Muta, K., & Nawata, H. (2017) · Endocrine Journal · doi:10.1507/endocrj.ej17-0390 · Cited by 179 · see citing works
Self-citationSantos-Marcos, J. A., Mora-Ortiz, M., Tena‐Sempere, M., López‐Miranda, J., & Camargo, A. (2023) · Biology of Sex Differences · doi:10.1186/s13293-023-00490-2 · Cited by 187 · see citing works
Androgen deficiency, diabetes, and the metabolic syndrome in men
Kalyani, R. R., & Dobs, A. S. (2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32814db856 · Cited by 172 · see citing works
Navarro, G., Xu, W., Jacobson, D. A., Wicksteed, B. L., Allard, C., Zhang, G., Gendt, K. D., Kim, S. H., Wu, H., Zhang, H., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.015 · Cited by 170 · see citing works
Effects of Age and Dysfunction on Human Meibomian Glands
Nien, C. J. (2011) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2011.69 · Cited by 164 · see citing works
Sex differences in energy metabolism: natural selection, mechanisms and consequences
Mauvais‐Jarvis, F. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00781-2 · Cited by 162 · see citing works
Sex Differences in Adipose Tissue Function
Gavin, K. M., & Bessesen, D. H. (2020) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2020.02.008 · Cited by 163 · see citing works
Obesity and late-onset hypogonadism
Corona, G., Vignozzi, L., Sforza, A., Mannucci, E., & Maggi, M. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.06.031 · Cited by 154 · see citing works
Androgen metabolism in adipose tissue: Recent advances
Blouin, K., Veilleux, A., Luu-The, V., & Tchernof, A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.035 · Cited by 149 · see citing works
Lu, M. M., Tang, Q., Olefsky, J. M., Mellon, P. L., & Webster, N. J. G. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0330 · Cited by 148 · see citing works
Vitamin D and energy homeostasis—of mice and men
Bouillon, R., Carmeliet, G., Lieben, L., 渡辺, 光., Perino, A., Auwerx, J. H., Schoonjans, K., & Verstuyf, A. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.226 · Cited by 144 · see citing works
Reproductive Endocrinology of Nonalcoholic Fatty Liver Disease
Grossmann, M., Wierman, M. E., Angus, P., & Handelsman, D. J. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00158 · Cited by 144 · see citing works
Zhang, H., Liu, Y., Wang, L., Li, Z., Zhang, H., Wu, J., Rahman, N. A., Guo, Y., Li, D., Li, N., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m028969 · Cited by 142 · see citing works
Fan, W., Imamura, T., Sonoda, N., Sears, D. D., Patsouris, D., Kim, J. J., & Olefsky, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808915200 · Cited by 134 · see citing works
Self-citationBlouin, K., Nadeau, M., Perreault, M., Veilleux, A., Drolet, R., Marceau, P., Mailloux, J. R., Luu‐The, V., & Tchernof, A. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03645.x · Cited by 131 · see citing works
Gendt, K. D., & Verhoeven, G. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.008 · Cited by 128 · see citing works
Endocrine disrupting chemicals in mixture and obesity, diabetes and related metabolic disorders
Magueresse‐Battistoni, B. L., Labaronne, E., Vidal, H., & Naville, D. (2017) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v8.i2.108 · Cited by 123 · see citing works
Ophoff, J., Proeyen, K. V., Callewaert, F., Gendt, K. D., Bock, K. D., Bosch, A. V., Verhoeven, G., Hespel, P., & Vanderschueren, D. (2009) · Endocrinology · doi:10.1210/en.2008-1509 · Cited by 123 · see citing works
McInnes, K. J., Smith, L. B., Hunger, N. I., Saunders, P. T. K., Andrew, R., & Walker, B. R. (2012) · Diabetes · doi:10.2337/db11-1136 · Cited by 121 · see citing works
Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome
Gao, A., Su, J., Liu, R., Zhao, S., Wen, L., Xu, X., Li, D., Shi, J., Gu, B., Zhang, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27187-7 · Cited by 121 · see citing works
Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice
Harada, N., Hanaoka, R., Horiuchi, H., Kitakaze, T., Mitani, T., Inui, H., & Yamaji, R. (2016) · Scientific Reports · doi:10.1038/srep23001 · Cited by 110 · see citing works
Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS)
Lanciotti, L., Cofini, M., Leonardi, A., Bertozzi, M., Penta, L., & Esposito, S. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16071268 · Cited by 115 · see citing works
The role of sex steroids in white adipose tissue adipocyte function
Newell‐Fugate, A. E. (2017) · Reproduction · doi:10.1530/rep-16-0417 · Cited by 114 · see citing works
Androgen Receptor-Dependent and Independent Atheroprotection by Testosterone in Male Mice
Fagman, J. B., Wilhelmson, A. S., Alexanderson, C., Gendt, K. D., Verhoeven, G., Krettek, A., Ohlsson, C., & Tivesten, Å. (2010) · Endocrinology · doi:10.1210/en.2010-0663 · Cited by 111 · see citing works
Androgen receptor functions in male and female physiology
Μatsumoto, T., Shiina, H., Kawano, H., Sato, T., & Kato, S. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.03.023 · Cited by 107 · see citing works
Self-citationHuman Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues
Singh, R., Barrios, A., Dirakvand, G., & Pervin, S. (2021) · Cells · doi:10.3390/cells10113030 · Cited by 109 · see citing works
Millward, C. A., Heaney, J. D., Sinasac, D. S., Chu, E. C., Bederman, I. R., Gilge, D. A., Previs, S. F., & Croniger, C. M. (2006) · Diabetes · doi:10.2337/db06-0310 · Cited by 103 · see citing works
The hypothalamus for whole-body physiology: from metabolism to aging
Liu, T., Xu, Y., Yi, C., Tong, Q., & Cai, D. (2021) · Protein & Cell · doi:10.1007/s13238-021-00834-x · Cited by 103 · see citing works
Androgens and metabolic syndrome: Lessons from androgen receptor knock out (ARKO) mice
Yanase, T., Fan, W., Kyoya, K., Min, L., Takayanagi, R., Kato, S., & Nawata, H. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.03.017 · Cited by 101 · see citing works
Self-citationUsui, T., Kajita, K., Kajita, T., Mori, I., Hanamoto, T., Ikeda, T., Okada, H., Taguchi, K., Kitada, Y., Morita, H., et al. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.051 · Cited by 100 · see citing works
Self-citationAndrogen Deficiency Exacerbates High-Fat Diet-Induced Metabolic Alterations in Male Mice
Dubois, V., Laurent, M. R., Jardí, F., Antonio, L., Lemaire, K., Goyvaerts, L., Deldicque, L., Carmeliet, G., Decallonne, B., Vanderschueren, D., et al. (2015) · Endocrinology · doi:10.1210/en.2015-1713 · Cited by 99 · see citing works
Haren, M. T., Siddiqui, A. M., Armbrecht, H. J., Kevorkian, R. T., Kim, M. J., Haas, M. J., Mazza, A. D., Kumar, V. B., Green, M., Banks, W. A., et al. (2010) · International Journal of Andrology · doi:10.1111/j.1365-2605.2010.01061.x · Cited by 99 · see citing works
Testosterone level and risk of type 2 diabetes in men: a systematic review and meta-analysis
Yao, Q., Wang, B., An, X., Zhang, J., & Ding, L. (2017) · Endocrine Connections · doi:10.1530/ec-17-0253 · Cited by 100 · see citing works
Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay
Mammi, C., Calanchini, M., Antelmi, A., Cinti, F., Rosano, G. M. C., Lenzi, A., Caprio, M., & Fabbri, A. (2012) · International Journal of Endocrinology · doi:10.1155/2012/789653 · Cited by 95 · see citing works
Sex Differences in Brown Adipose Tissue Function: Sex Hormones, Glucocorticoids, and Their Crosstalk
Kaikaew, K., Grefhorst, A., & Visser, J. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.652444 · Cited by 96 · see citing works
Sex Steroid Receptor Expression Profile in Brown Adipose Tissue. Effects of Hormonal Status
Rodriguez-Cuenca, S., Monjo, M., Frontera, M., Gianotti, M., Proenza, A. M., & Roca, P. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110448 · Cited by 92 · see citing works
Rumanova, V. S., Okuliarová, M., & Zeman, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155478 · Cited by 93 · see citing works
Chang, C., Yeh, S., Lee, S. O., & Chang, T. (2013) · Nuclear Receptor Signaling · doi:10.1621/nrs.11001 · Cited by 91 · see citing works
Testosterone treatment improves metabolic syndrome-induced adipose tissue derangements
Maneschi, E., Morelli, A., Filippi, S., Cellai, I., Comeglio, P., Mazzanti, B., Mello, T., Calcagno, A., Sarchielli, E., Vignozzi, L., et al. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0333 · Cited by 89 · see citing works
Western-style diet, sex steroids and metabolism
Varlamov, O. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.05.025 · Cited by 89 · see citing works
Testosterone Replacement Ameliorates Nonalcoholic Fatty Liver Disease in Castrated Male Rats
Nikolaenko, L., Jia, Y., Wang, C., Diaz‐Arjonilla, M., Yee, J. K., French, S. W., Liu, P. Y., Laurel, S., Chong, C., Lee, K., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1648 · Cited by 87 · see citing works
PPARγ Regulates Mouse Meibocyte Differentiation and Lipid Synthesis
Jester, J. V., Potma, E. O., & Brown, D. J. (2016) · The Ocular Surface · doi:10.1016/j.jtos.2016.08.001 · Cited by 87 · see citing works
Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology
Torre, S. D. (2021) · Cells · doi:10.3390/cells10092502 · Cited by 89 · see citing works
Borniger, J. C., Maurya, S. K., Periasamy, M., & Nelson, R. J. (2014) · Chronobiology International · doi:10.3109/07420528.2014.926911 · Cited by 84 · see citing works
Human androgen deficiency: insights gained from androgen receptor knockout mouse models
Zajac, J. D., Rana, K., & Davey, R. A. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122590 · Cited by 84 · see citing works
Sex Hormones and Macronutrient Metabolism
Comitato, R., Saba, A., Turrini, A., Arganini, C., & Virgili, F. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.651177 · Cited by 83 · see citing works
Senmaru, T., Fukui, M., Okada, H., Mineoka, Y., Yamazaki, M., Tsujikawa, M., Hasegawa, G., Kitawaki, J., Obayashi, H., & Nakamura, N. (2013) · Metabolism · doi:10.1016/j.metabol.2012.12.007 · Cited by 82 · see citing works
Albertelli, M. A., Scheller, A., Brogley, M. A., & Robins, D. M. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0021 · Cited by 82 · see citing works
Mechanisms for sex differences in energy homeostasis
Wang, C., & Xu, Y. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0165 · Cited by 80 · see citing works
Gharahdaghi, N., Rudrappa, S. S., Brook, M. S., IDRIS, I. R., Crossland, H., Hamrock, C., Aziz, M. H. A., Kadi, F., Tarum, J., Greenhaff, P. L., et al. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12472 · Cited by 82 · see citing works
Metabolic benefits afforded by estradiol and testosterone in both sexes: clinical considerations
Mauvais‐Jarvis, F., & Lindsey, S. H. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180073 · Cited by 88 · see citing works
Rana, K., Fam, B. C., Clarke, M. V., Pang, T. P. S., Zajac, J. D., & MacLean, H. E. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00584.2010 · Cited by 78 · see citing works
Yoshida, S., Aihara, K., Ikeda, Y., Sumitomo-Ueda, Y., Uemoto, R., Ishikawa, K., Ise, T., Yagi, S., Iwase, T., Mouri, Y., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.001533 · Cited by 73 · see citing works
Self-citationBody Composition and Metabolic Profile in Women with Complete Androgen Insensitivity Syndrome
Dati, E., Baroncelli, G., Mora, S., Russo, G., Baldinotti, F., Parrini, D., Erba, P. A., Simi, P., & Bertelloni, S. (2009) · Sexual Development · doi:10.1159/000228719 · Cited by 71 · see citing works
Yu, I.-C. I., Lin, H., Sparks, J. D., Yeh, S., & Chang, C. (2014) · Diabetes · doi:10.2337/db13-1505 · Cited by 71 · see citing works
Myocyte Androgen Receptors Increase Metabolic Rate and Improve Body Composition by Reducing Fat Mass
Fernando, S. M., Rao, P., Niel, L., Chatterjee, D., Stagljar, M., & Monks, D. A. (2010) · Endocrinology · doi:10.1210/en.2010-0018 · Cited by 69 · see citing works
Liu, X., & Shi, H. (2015) · International Journal of Endocrinology · doi:10.1155/2015/949085 · Cited by 70 · see citing works
Hypogonadism alters cecal and fecal microbiota in male mice
Harada, N., Hanaoka, R., Hanada, K., Izawa, T., Inui, H., & Yamaji, R. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1239680 · Cited by 68 · see citing works
Dihydrotestosterone Suppresses Foam Cell Formation and Attenuates Atherosclerosis Development
Qiu, Y., Yanase, T., Hu, H., Tanaka, T., Nishi, Y., Liu, M., Sueishi, K., Sawamura, T., & Nawata, H. (2010) · Endocrinology · doi:10.1210/en.2009-1268 · Cited by 66 · see citing works
Self-citationImpairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity
Sakamoto, S., Miyaji, T., Hiasa, M., Ichikawa, R., Uematsu, A., Iwatsuki, K., Shibata, A., Uneyama, H., Takayanagi, R., Yamamoto, A., et al. (2014) · Scientific Reports · doi:10.1038/srep06689 · Cited by 66 · see citing works
Self-citationWiren, K. M., Semirale, A. A., Zhang, X.-W., Woo, A., Tommasini, S. M., Price, C., Schaffler, M. B., & Jepsen, K. J. (2008) · Bone · doi:10.1016/j.bone.2008.04.026 · Cited by 65 · see citing works
Expression of estrogen receptor alpha increases leptin‐induced STAT3 activity in breast cancer cells
Binai, N. A., Damert, A., Carra, G., Steckelbroeck, S., Löwer, J., Löwer, R., & Weßler, S. (2009) · International Journal of Cancer · doi:10.1002/ijc.25010 · Cited by 65 · see citing works
Role of sex hormones in modulation of brown adipose tissue activity
Quarta, C., Mazza, R., Pasquali, R., & Pagotto, U. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0043 · Cited by 64 · see citing works
Peripheral signalling involved in energy homeostasis control
Lancha, A., Frühbeck, G., & Gómez‐Ambrosi, J. (2012) · Nutrition Research Reviews · doi:10.1017/s0954422412000145 · Cited by 65 · see citing works
Zebrafish androgen receptor is required for spermatogenesis and maintenance of ovarian function
Yu, G., Zhang, D., Liu, W., Wang, J., Liu, X., Zhou, C., Gui, J., & Xiao, W. (2018) · Oncotarget · doi:10.18632/oncotarget.24407 · Cited by 62 · see citing works
Androgen receptor counteracts Doxorubicin-induced cardiotoxicity in male mice.
Ikeda, Y., Aihara, K.-I., Akaike, M., Sato, T., Ishikawa, K., Ise, T., Yagi, S., Iwase, T., Ueda, Y., Yoshida, S., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0402 · Cited by 70 · see citing works
Self-citationTestosterone a key factor in gender related metabolic syndrome
Bianchi, V. E., & Locatelli, V. (2018) · Obesity Reviews · doi:10.1111/obr.12633 · Cited by 61 · see citing works
Romero, M., Sabaté-Pérez, A., Francis, V. A., Castrillon‐Rodríguez, I., Díaz‐Ramos, A., Sánchez‐Feutrie, M., Durán, X., Palacı́n, M., Moreno‐Navarrete, J. M., Gustafson, B., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0072-9 · Cited by 60 · see citing works
Subbarayalu, P., Viswanadhapalli, S., Abdelfattah, N., Onyeagucha, B. C., Timilsina, S., Mohammad, T. A., Chen, Y., Drake, M. T., Vuori, K., Kumar, T. R., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00590-9 · Cited by 60 · see citing works
Estrogens and Body Weight Regulation in Men
Rubinow, K. B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_14 · Cited by 60 · see citing works
Androgen dysfunction in non-alcoholic fatty liver disease: Role of sex hormone binding globulin
Song, M. J., & Choi, J. Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1053709 · Cited by 59 · see citing works
Estradiol treatment, physical activity, and muscle function in ovarian-senescent mice
Greising, S. M., Carey, R. S., Blackford, J. E., Dalton, L. E., Kosir, A. M., & Lowe, D. A. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.04.006 · Cited by 55 · see citing works
Fagman, J. B., Wilhelmson, A. S., Motta, B. M., Pirazzi, C., Alexanderson, C., Gendt, K. D., Verhoeven, G., Holmäng, A. B., Anesten, F., Jansson, J., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-259234 · Cited by 55 · see citing works
Sex differences in the effects of androgens acting in the central nervous system on metabolism
Morford, J. J., & Mauvais‐Jarvis, F. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.4/fmauvais · Cited by 53 · see citing works
An overview on androgen-mediated actions in skeletal muscle and adipose tissue
Rizk, J. G., Sahu, R., & Duteil, D. (2023) · Steroids · doi:10.1016/j.steroids.2023.109306 · Cited by 52 · see citing works
The influence of sex steroids on adipose tissue growth and function
Law, J., Bloor, I. D., Budge, H., & Symonds, M. E. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0015 · Cited by 48 · see citing works
- Authors
- Fan, W., Yanase, T., Nomura, M., Okabe, T., Goto, K., Sato, T., Kawano, H., Kato, S., & Nawata, H.
- Affiliations
- Kyushu University (JP)
- The University of Tokyo (JP)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2005-04-01
- Volume
- 54
- Issue
- 4
- Pages
- 1000-1008
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2027264386
- Cited by
- 269
- References
- 45
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 15 · 2023: 8 · 2022: 18 · 2021: 13 · 2020: 11 · 2019: 6 · 2018: 18 · 2017: 21 · 2016: 17 · 2015: 18 · 2014: 16 · 2013: 15 · 2012: 11
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- green
- pure.teikyo.jp
- Licence
- cc-by-nc-nd
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- androgen receptor, late-onset obesity, energy expenditure, lipolysis, insulin sensitivity, adiponectin secretion, UCP1, thermogenesis, PPARγ, white adipose tissue, energy balance, euphoria
- MeSH terms
- Uncoupling Protein 1, Adipose Tissue, Aging, Animals, Body Weight, Carrier Proteins, Energy Metabolism, Insulin, Insulin Resistance, Ion Channels, Lipolysis, Male, Membrane Proteins, Obesity, Oxygen Consumption, Receptors, Androgen, Gene Expression, Mice, Knockout, Mitochondrial Proteins, Intercellular Signaling Peptides and Proteins, Mice, Adiponectin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review