The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Saved by the Nose: Bystander-Administered Intranasal Naloxone Hydrochloride for Opioid Overdose
Open accessAbstract
Administering naloxone hydrochloride (naloxone) during an opioid overdose reverses the overdose and can prevent death. Although typically delivered via intramuscular or intravenous injection, naloxone may be delivered via intranasal spray device. In August 2006, the Boston Public Health Commission passed a public health regulation that authorized an opioid overdose prevention program that included intranasal naloxone education and distribution of the spray to potential bystanders. Participants were taught by trained nonmedical needle exchange staff. After 15 months, the program provided training and intranasal naloxone to 385 participants who reported 74 successful overdose reversals. Problems with intranasal naloxone were uncommon. Overdose prevention education with distribution of intranasal naloxone is a feasible public health intervention to address opioid overdose.
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“This route of administration has been validated for both OT (6, 71) and NAL (72–74) in previous human studies”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [74]
Citations
Cites
Increasing deaths from opioid analgesics in the United States
Paulozzi, L. J., Budnitz, D. S., & Xi, Y. (2006) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1276 · Cited by 696
Seal, K. H. (2005) · Journal of Urban Health · doi:10.1093/jurban/jti053 · Cited by 244
Prescribing Naloxone to Actively Injecting Heroin Users: A Program to Reduce Heroin Overdose Deaths
Maxwell, S., Bigg, D., Stanczykiewicz, K., & Carlberg-Racich, S. (2006) · Journal of Addictive Diseases · doi:10.1300/j069v25n03_11 · Cited by 242
Green, T. C., Heimer, R. R., & Grau, L. E. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02182.x · Cited by 192
Kelly, A., Kerr, D. C., Koutsogiannis, Z., Dietze, P., Patrick, I., & Walker, T. (2005) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2005.tb06550.x · Cited by 163
Take home naloxone and the prevention of deaths from opiate overdose: two pilot schemes
Dettmer, K., Saunders, B., & Strang, J. (2001) · BMJ · doi:10.1136/bmj.322.7291.895 · Cited by 158
Tobin, K. E., Sherman, S. G., Beilenson, P. L., Welsh, C., & Latkin, C. A. (2008) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2008.03.002 · Cited by 149
Take‐home naloxone to reduce heroin death
Baca, C. T., & Grant, K. J. (2005) · Addiction · doi:10.1111/j.1360-0443.2005.01259.x · Cited by 137
Barton, E. D., Colwell, C. B., Wolfe, T. R., Fosnocht, D., Gravitz, C. S., Bryan, T. S., Dunn, W., Benson, J., & Bailey, J. E. (2005) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2005.03.007 · Cited by 136
Galea, S., Worthington, N., Piper, T. M., Nandi, V., Curtis, M., & ROSENTHAL, D. M. (2005) · Addictive Behaviors · doi:10.1016/j.addbeh.2005.07.020 · Cited by 131
Shah, N. G., Lathrop, S. L., Reichard, R. R., & Landen, M. G. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.02054.x · Cited by 122
Prescription Naloxone: A Novel Approach to Heroin Overdose Prevention
Sporer, K. A., & Kral, A. H. (2006) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2006.05.025 · Cited by 117
Opioid Analgesic Involvement in Drug Abuse Deaths in American Metropolitan Areas
Paulozzi, L. J. (2006) · American Journal of Public Health · doi:10.2105/ajph.2005.071647 · Cited by 109
I NTRANASAL A DMINISTRATION OF N ALOXONE BY P ARAMEDICS
Barton, E. D., Ramos, J., Colwell, C., Benson, J., Baily, J., & Dunn, W. (2002) · Prehospital Emergency Care · doi:10.1080/10903120290938797 · Cited by 76
Legal aspects of providing naloxone to heroin users in the United States
Burris, S. C., Norland, J., & Edlin, B. R. (2001) · International Journal of Drug Policy · doi:10.1016/s0955-3959(01)00080-9 · Cited by 75
Sherman, S. G., Gann, D. S., Tobin, K. E., Latkin, C. A., Welsh, C., & Bielenson, P. (2008) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2008.02.004 · Cited by 72
Piper, T. M., Rudenstine, S., Stancliff, S., Sherman, S. G., Nandi, V., Clear, A., & Galea, S. (2007) · Harm Reduction Journal · doi:10.1186/1477-7517-4-3 · Cited by 69
Nasal Administration of Naloxone Is as Effective as the Intravenous Route in Opiate Addicts
Loimer, N., Hofmann, P. J., & Chaudhry, H. R. (1994) · International Journal of the Addictions · doi:10.3109/10826089409047912 · Cited by 66
Strang, J., Manning, V., Mayet, S., Titherington, E., Offor, L., Semmler, C., & Williams, A. (2008) · Drugs Education Prevention and Policy · doi:10.1080/09687630701731205 · Cited by 48
Intranasal naloxone in suspected opioid overdose
Ashton, H. (2006) · Emergency Medicine Journal · doi:10.1136/emj.2005.034322 · Cited by 47
Data on take home naloxone are unclear but not condemnatory
Bigg, D. (2002) · BMJ · doi:10.1136/bmj.324.7338.678 · Cited by 38
Unintentional opiate overdose deaths--King County, Washington, 1990-1999.
(2000) · PubMed · Cited by 32
Heroin overdose deaths--Multnomah County, Oregon, 1993-1999.
(2000) · PubMed · Cited by 31
Trends in opioid-related fatal overdoses in Massachusetts, 1990–2003
Fernandez, W. G., Hackman, H., McKeown, L., Anderson, T., & Hume, B. (2006) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2006.04.008 · Cited by 29
Self-Injectable Epinephrine for Allergic Emergencies
Davis, J. E. (2008) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2007.06.038 · Cited by 18
Flagged first, then by citations
Research works printed but not linked: 5
- Centers for Disease Control and Prevention, 2000, MMWR Morb Mortal Wkly Rep, 49, 636
- Centers for Disease Control and Prevention, 2000, MMWR Morb Mortal Wkly Rep, 49, 633
- Sherman SG, Int J Drug Policy
- Tobin KE, Int J Drug Policy
- Davis JE, 2008, J Emerg Med
Cited by
Sorted by citations
Walley, A. Y., Xuan, Z., Hackman, H. H., Quinn, E., Doe-Simkins, M., Sorensen-Alawad, A., Ruiz, S., & Ozonoff, A. (2013) · BMJ · doi:10.1136/bmj.f174 · Cited by 999
A Systematic Review of Community Opioid Overdose Prevention and Naloxone Distribution Programs
Clark, A. K., Wilder, C. M., & Winstanley, E. L. (2014) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000034 · Cited by 490
McDonald, R., & Strang, J. (2016) · Addiction · doi:10.1111/add.13326 · Cited by 472
Naloxone dosage for opioid reversal: current evidence and clinical implications
Lynn, R. R., & Galinkin, J. L. (2017) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098617744161 · Cited by 363
Cost-Effectiveness of Distributing Naloxone to Heroin Users for Lay Overdose Reversal
Coffin, P. O., & Sullivan, S. D. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-1-201301010-00003 · Cited by 347
Metadata
- Authors
- Doe-Simkins, M., Walley, A. Y., Epstein, A., & Moyer, P.
- Affiliations
- Boston University (US)
- Venue
- American Journal of Public Health
- Publisher
- American Public Health Association
- Published
- 2009-05
- Volume
- 99
- Issue
- 5
- Pages
- 788-791
- ISSN
- 0090-0036 (ISSN-L)
- 1541-0048
- PMC
- PMC2667836
- OpenAlex
- W2160243203
- Cited by
- 250
- References
- 25
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 19 · 2021: 20 · 2020: 13 · 2019: 17 · 2018: 20 · 2017: 19 · 2016: 25 · 2015: 22 · 2014: 22 · 2013: 14 · 2012: 9
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Public Health (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Keywords
- intranasal naloxone, opioid overdose, overdose reversal, bystander intervention, public health regulation, harm reduction, opioid use disorder
- MeSH terms
- Administration, Intranasal, Adult, Emergency Medical Services, Female, Humans, Male, Naloxone, Narcotic Antagonists, Opioid-Related Disorders, Risk Factors, Program Evaluation, Needle-Exchange Programs, Drug Overdose
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