Cited by 250Opioid Use Disorder TreatmentSubstance Abuse Treatment and OutcomesHIV, Drug Use, Sexual Risk

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Saved by the Nose: Bystander-Administered Intranasal Naloxone Hydrochloride for Opioid Overdose

Open access

Doe-Simkins, Maya, Walley, Alexander Y., Epstein, Andy, Moyer, Peter·2009·American Journal of Public Health

DOI 10.2105/ajph.2008.146647PMC PMC2667836

Open this paper in CoChat — free account

Abstract

Administering naloxone hydrochloride (naloxone) during an opioid overdose reverses the overdose and can prevent death. Although typically delivered via intramuscular or intravenous injection, naloxone may be delivered via intranasal spray device. In August 2006, the Boston Public Health Commission passed a public health regulation that authorized an opioid overdose prevention program that included intranasal naloxone education and distribution of the spray to potential bystanders. Participants were taught by trained nonmedical needle exchange staff. After 15 months, the program provided training and intranasal naloxone to 385 participants who reported 74 successful overdose reversals. Problems with intranasal naloxone were uncommon. Overdose prevention education with distribution of intranasal naloxone is a feasible public health intervention to address opioid overdose.

Integrity signals

Registry

Crossref · 10.2105/ajph.2008.146647

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Increasing deaths from opioid analgesics in the United States
Paulozzi, L. J., Budnitz, D. S., & Xi, Y. (2006) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1276 · Cited by 696
Naloxone Distribution and Cardiopulmonary Resuscitation Training for Injection Drug Users to Prevent Heroin Overdose Death: A Pilot Intervention Study
Seal, K. H. (2005) · Journal of Urban Health · doi:10.1093/jurban/jti053 · Cited by 244
Prescribing Naloxone to Actively Injecting Heroin Users: A Program to Reduce Heroin Overdose Deaths
Maxwell, S., Bigg, D., Stanczykiewicz, K., & Carlberg-Racich, S. (2006) · Journal of Addictive Diseases · doi:10.1300/j069v25n03_11 · Cited by 242
Distinguishing signs of opioid overdose and indication for naloxone: an evaluation of six overdose training and naloxone distribution programs in the United States
Green, T. C., Heimer, R. R., & Grau, L. E. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02182.x · Cited by 192
Randomised trial of intranasal versus intramuscular naloxone in prehospital treatment for suspected opioid overdose
Kelly, A., Kerr, D. C., Koutsogiannis, Z., Dietze, P., Patrick, I., & Walker, T. (2005) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2005.tb06550.x · Cited by 163
Take home naloxone and the prevention of deaths from opiate overdose: two pilot schemes
Dettmer, K., Saunders, B., & Strang, J. (2001) · BMJ · doi:10.1136/bmj.322.7291.895 · Cited by 158
Evaluation of the Staying Alive programme: Training injection drug users to properly administer naloxone and save lives
Tobin, K. E., Sherman, S. G., Beilenson, P. L., Welsh, C., & Latkin, C. A. (2008) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2008.03.002 · Cited by 149
Take‐home naloxone to reduce heroin death
Baca, C. T., & Grant, K. J. (2005) · Addiction · doi:10.1111/j.1360-0443.2005.01259.x · Cited by 137
Efficacy of intranasal naloxone as a needleless alternative for treatment of opioid overdose in the prehospital setting
Barton, E. D., Colwell, C. B., Wolfe, T. R., Fosnocht, D., Gravitz, C. S., Bryan, T. S., Dunn, W., Benson, J., & Bailey, J. E. (2005) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2005.03.007 · Cited by 136
Provision of naloxone to injection drug users as an overdose prevention strategy: Early evidence from a pilot study in New York City
Galea, S., Worthington, N., Piper, T. M., Nandi, V., Curtis, M., & ROSENTHAL, D. M. (2005) · Addictive Behaviors · doi:10.1016/j.addbeh.2005.07.020 · Cited by 131

Show all 25 references

Research works printed but not linked: 5

Centers for Disease Control and Prevention, 2000, MMWR Morb Mortal Wkly Rep, 49, 636
Centers for Disease Control and Prevention, 2000, MMWR Morb Mortal Wkly Rep, 49, 633
Sherman SG, Int J Drug Policy
Tobin KE, Int J Drug Policy
Davis JE, 2008, J Emerg Med

Sorted by citations

Opioid overdose rates and implementation of overdose education and nasal naloxone distribution in Massachusetts: interrupted time series analysis
Walley, A. Y., Xuan, Z., Hackman, H. H., Quinn, E., Doe-Simkins, M., Sorensen-Alawad, A., Ruiz, S., & Ozonoff, A. (2013) · BMJ · doi:10.1136/bmj.f174 · Cited by 999
A Systematic Review of Community Opioid Overdose Prevention and Naloxone Distribution Programs
Clark, A. K., Wilder, C. M., & Winstanley, E. L. (2014) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000034 · Cited by 490
Are take‐home naloxone programmes effective? Systematic review utilizing application of the Bradford Hill criteria
McDonald, R., & Strang, J. (2016) · Addiction · doi:10.1111/add.13326 · Cited by 472
Naloxone dosage for opioid reversal: current evidence and clinical implications
Lynn, R. R., & Galinkin, J. L. (2017) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098617744161 · Cited by 363
Cost-Effectiveness of Distributing Naloxone to Heroin Users for Lay Overdose Reversal
Coffin, P. O., & Sullivan, S. D. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-1-201301010-00003 · Cited by 347
Return to drug use and overdose after release from prison: A qualitative study of risk and protective factors
Binswanger, I. A., Nowels, C., Corsi, K. F., Glanz, J., Long, J., Booth, R. E., & Steiner, J. F. (2012) · Addiction Science & Clinical Practice · doi:10.1186/1940-0640-7-3 · Cited by 329
The Opioid Epidemic: Crisis and Solutions
Skolnick, P. (2018) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052534 · Cited by 307
Heroin uncertainties: Exploring users’ perceptions of fentanyl-adulterated and -substituted ‘heroin’
Ciccarone, D., Ondocsin, J., & Mars, S. G. (2017) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2017.06.004 · Cited by 291
Part 10: Special Circumstances of Resuscitation
Lavonas, E. J., Drennan, I. R., Gabrielli, A., Heffner, A. C., Hoyte, C. O., Orkin, A. M., Sawyer, K. N., & Donnino, M. W. (2015) · Circulation · doi:10.1161/cir.0000000000000264 · Cited by 276
Naloxone for heroin, prescription opioid, and illicitly made fentanyl overdoses: Challenges and innovations responding to a dynamic epidemic
Fairbairn, N. S., Coffin, P. O., & Walley, A. Y. (2017) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2017.06.005 · Cited by 288
What we know, and don't know, about the impact of state policy and systems-level interventions on prescription drug overdose
Haegerich, T. M., Paulozzi, L. J., Manns, B. J., & Jones, C. M. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.10.001 · Cited by 272
Community-Based Opioid Overdose Prevention Programs Providing Naloxone —United States, 2010
Wheeler, E., Davidson, P. J., Jones, T. S., & Irwin, K. S. (2012) · JAMA · doi:10.1001/jama.307.13.1358 · Cited by 257
Intertwined Epidemics: National Demographic Trends in Hospitalizations for Heroin- and Opioid-Related Overdoses, 1993–2009
Unick, G. J., Rosenblum, D., Mars, S. G., & Ciccarone, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054496 · Cited by 255
A Review of Opioid Overdose Prevention and Naloxone Prescribing: Implications for Translating Community Programming into Clinical Practice
Mueller, S. R., Walley, A. Y., Calcaterra, S. L., Glanz, J. M., & Binswanger, I. A. (2015) · Substance Abuse · doi:10.1080/08897077.2015.1010032 · Cited by 193
Overdose Prevention and Naloxone Prescription for Opioid Users in San Francisco
Enteen, L., Bauer, J., McLean, R., Wheeler, E., Huriaux, E., Kral, A. H., & Bamberger, J. D. (2010) · Journal of Urban Health · doi:10.1007/s11524-010-9495-8 · Cited by 185
Randomized controlled trial comparing the effectiveness and safety of intranasal and intramuscular naloxone for the treatment of suspected heroin overdose
Kerr, D. C., Kelly, A., Dietze, P., Jolley, D., & Barger, B. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02724.x · Cited by 175
Overdose rescues by trained and untrained participants and change in opioid use among substance-using participants in overdose education and naloxone distribution programs: a retrospective cohort study
Doe-Simkins, M., Quinn, E. K., Xuan, Z., Sorensen-Alawad, A., Hackman, H., Ozonoff, A., & Walley, A. Y. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-297 · Cited by 175
Do more robust prescription drug monitoring programs reduce prescription opioid overdose?
Pardo, B. (2016) · Addiction · doi:10.1111/add.13741 · Cited by 174
COVID-19 and the Drug Overdose Crisis: Uncovering the Deadliest Months in the United States, January‒July 2020
Friedman, J. R., & Akre, S. (2021) · American Journal of Public Health · doi:10.2105/ajph.2021.306256 · Cited by 168
Legal changes to increase access to naloxone for opioid overdose reversal in the United States
Davis, C. S., & Carr, D. H. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.10.013 · Cited by 166
Review of naloxone safety for opioid overdose: practical considerations for new technology and expanded public access
Wermeling, D. P. (2015) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098614564776 · Cited by 164
The Opioid Epidemic in the United States
Wilkerson, R. G., Kim, H., Windsor, T. A., & Mareiniss, D. P. (2016) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2015.11.002 · Cited by 161
Twenty years of take-home naloxone for the prevention of overdose deaths from heroin and other opioids—Conception and maturation
McDonald, R., CAMPBELL, N. D., & Strang, J. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.05.001 · Cited by 147
Police Officers’ and Paramedics’ Experiences with Overdose and Their Knowledge and Opinions of Washington State’s Drug Overdose–Naloxone–Good Samaritan Law
Banta‐Green, C. J., Beletsky, L. A., Schoeppe, J. A., Coffin, P. O., & Kuszler, P. C. (2013) · Journal of Urban Health · doi:10.1007/s11524-013-9814-y · Cited by 140
High risk and little knowledge: Overdose experiences and knowledge among young adult nonmedical prescription opioid users
Frank, D., Mateu‐Gelabert, P., Guarino, H., Bennett, A. S., Wendel, T., Jessell, L., & Teper, A. (2014) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2014.07.013 · Cited by 130
A pilot randomized clinical trial of an intervention to reduce overdose risk behaviors among emergency department patients at risk for prescription opioid overdose
Bohnert, A. S. B., Bonar, E. E., Cunningham, R., Greenwald, M. K., Thomas, L., Chermack, S., Blow, F. C., & Walton, M. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.03.018 · Cited by 123
Overdose Education and Naloxone for Patients Prescribed Opioids in Primary Care: A Qualitative Study of Primary Care Staff
Binswanger, I. A., Koester, S. K., Mueller, S. R., Gardner, E. M., Goddard, K., & Glanz, J. M. (2015) · Journal of General Internal Medicine · doi:10.1007/s11606-015-3394-3 · Cited by 129
Sold as Heroin: Perceptions and Use of an Evolving Drug in Baltimore, MD
Mars, S. G., Ondocsin, J., & Ciccarone, D. (2017) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2017.1394508 · Cited by 127
Take-Home Naloxone for the Emergency Interim Management of Opioid Overdose: The Public Health Application of an Emergency Medicine
Strang, J., McDonald, R., Campbell, G., Degenhardt, L. J., Nielsen, S., Ritter, A. J., & Dale, O. (2019) · Drugs · doi:10.1007/s40265-019-01154-5 · Cited by 136
Injection Drug Users Trained by Overdose Prevention Programs: Responses to Witnessed Overdoses
Lankenau, S. E., Wagner, K. D., Silva, K., Kecojević, A., Iverson, E., McNeely, M., & Kral, A. H. (2012) · Journal of Community Health · doi:10.1007/s10900-012-9591-7 · Cited by 123
Treatment of overdose in the synthetic opioid era
Skolnick, P. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108019 · Cited by 123
Orienting patients to greater opioid safety: models of community pharmacy-based naloxone
Green, T. C., Dauria, E., Bratberg, J. P., Davis, C. S., & Walley, A. Y. (2015) · Harm Reduction Journal · doi:10.1186/s12954-015-0058-x · Cited by 114
Impact of a community-based naloxone distribution program on opioid overdose death rates
Naumann, R. B., Durrance, C. P., Ranapurwala, S. I., Austin, A. E., Proescholdbell, S., Childs, R., Marshall, S. W., Kansagra, S., & Shanahan, M. E. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.06.038 · Cited by 112
Pharmacokinetic Properties and Human Use Characteristics of an FDA‐Approved Intranasal Naloxone Product for the Treatment of Opioid Overdose
Krieter, P. A., Chiang, N., Gyaw, S., Skolnick, P., Crystal, R., Keegan, F., Aker, J., Beck, M., & Harris, J. J. (2016) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.759 · Cited by 111
Training family members to manage heroin overdose and administer naloxone: randomized trial of effects on knowledge and attitudes
Williams, A., Marsden, J., & Strang, J. (2013) · Addiction · doi:10.1111/add.12360 · Cited by 109
Opioid overdose prevention with intranasal naloxone among people who take methadone
Walley, A. Y., Doe-Simkins, M., Quinn, E., Pierce, C., Xuan, Z., & Ozonoff, A. (2013) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2012.07.004 · Cited by 107
Prevention of Fatal Opioid Overdose
Beletsky, L. A., Rich, J. D., & Walley, A. Y. (2012) · JAMA · doi:10.1001/jama.2012.14205 · Cited by 103
HIV infection and risk of overdose
Green, T. C., McGowan, S. K., Yokell, M. A., Pouget, E. R., & Rich, J. D. (2011) · AIDS · doi:10.1097/qad.0b013e32834f19b6 · Cited by 103
Naloxone for Opioid Overdose Prevention
Bailey, A. M., & Wermeling, D. P. (2014) · Annals of Pharmacotherapy · doi:10.1177/1060028014523730 · Cited by 102
Pharmacokinetics of concentrated naloxone nasal spray for opioid overdose reversal: Phase I healthy volunteer study
McDonald, R., Lorch, U., Woodward, J., Bosse, B., Dooner, H., Mundin, G., Smith, K. J., & Strang, J. (2017) · Addiction · doi:10.1111/add.14033 · Cited by 98
Opioid overdose detection using smartphones
Nandakumar, R., Gollakota, S., & Sunshine, J. E. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau8914 · Cited by 102
Toots, tastes and tester shots: user accounts of drug sampling methods for gauging heroin potency
Mars, S. G., Ondocsin, J., & Ciccarone, D. (2018) · Harm Reduction Journal · doi:10.1186/s12954-018-0232-z · Cited by 96
Brief overdose education is sufficient for naloxone distribution to opioid users
Behar, E., Santos, G., Wheeler, E., Rowe, C. L., & Coffin, P. O. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.12.009 · Cited by 95
Disparity in Naloxone Administration by Emergency Medical Service Providers and the Burden of Drug Overdose in US Rural Communities
Faul, M., Dailey, M. W., Sugerman, D. E., Sasser, S. M., Levy, B., & Paulozzi, L. J. (2015) · American Journal of Public Health · doi:10.2105/ajph.2014.302520 · Cited by 92
Adoption and Utilization of an Emergency Department Naloxone Distribution and Peer Recovery Coach Consultation Program
Samuels, E. A., Baird, J. R., Yang, E. S., & Mello, M. J. (2018) · Academic Emergency Medicine · doi:10.1111/acem.13545 · Cited by 94
Epidemiologic trends and geographic patterns of fatal opioid intoxications in Connecticut, USA: 1997–2007
Green, T. C., Grau, L. E., Carver, H. W., Kinzly, M. L., & Heimer, R. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.11.007 · Cited by 90
Exploring the life-saving potential of naloxone: A systematic review and descriptive meta-analysis of take home naloxone (THN) programmes for opioid users
McAuley, A., Aucott, L. S., & Matheson, C. (2015) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2015.09.011 · Cited by 90
Messaging to Increase Public Support for Naloxone Distribution Policies in the United States: Results from a Randomized Survey Experiment
Bachhuber, M. A., McGinty, E. E., Kennedy‐Hendricks, A., Niederdeppe, J., & Barry, C. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130050 · Cited by 90
When to Pick the Nose: Out-of-Hospital and Emergency Department Intranasal Administration of Medications
Rech, M. A., Barbas, B., Chaney, W., Greenhalgh, E., & Turck, C. J. (2017) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2017.02.015 · Cited by 92
Reasons People Who Use Opioids Do Not Accept or Carry No-Cost Naloxone: Qualitative Interview Study
Bennett, A. S., Freeman, R., Jarlais, D. C. D., & Aronson, I. D. (2020) · JMIR Formative Research · doi:10.2196/22411 · Cited by 89
Intranasal naloxone administration for treatment of opioid overdose
Robinson, A., & Wermeling, D. P. (2014) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp130798 · Cited by 87
Emergency Department‐based Opioid Harm Reduction: Moving Physicians From Willing to Doing
Samuels, E. A., Dwyer, K. H., Mello, M. J., Baird, J. R., Kellogg, A. R., & Bernstein, E. (2016) · Academic Emergency Medicine · doi:10.1111/acem.12910 · Cited by 86
Emergency Medical Services Naloxone Access: A National Systematic Legal Review
Davis, C. S., Southwell, J. K., Niehaus, V. R., Walley, A. Y., & Dailey, M. W. (2014) · Academic Emergency Medicine · doi:10.1111/acem.12485 · Cited by 84
Predictors of participant engagement and naloxone utilization in a community‐based naloxone distribution program
Rowe, C. L., Santos, G., Vittinghoff, E., Wheeler, E., Davidson, P. J., & Coffin, P. O. (2015) · Addiction · doi:10.1111/add.12961 · Cited by 83
Prescribe to Prevent: Overdose Prevention and Naloxone Rescue Kits for Prescribers and Pharmacists
Lim, J. K., Bratberg, J. P., Davis, C. S., Green, T. C., & Walley, A. Y. (2016) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000223 · Cited by 82
Effects of naloxone distribution to likely bystanders: Results of an agent-based model
Keane, C., Egan, J. E., & Hawk, M. E. (2018) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2018.02.008 · Cited by 82
Typologies of Prescription Opioid Use in a Large Sample of Adults Assessed for Substance Abuse Treatment
Green, T. C., Black, R. A., Serrano, J. M. G., Budman, S. H., & Butler, S. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027244 · Cited by 81
Engaging Law Enforcement in Overdose Reversal Initiatives: Authorization and Liability for Naloxone Administration
Davis, C. S., Carr, D. H., Southwell, J. K., & Beletsky, L. A. (2015) · American Journal of Public Health · doi:10.2105/ajph.2015.302638 · Cited by 79
The opioid abuse and misuse epidemic: Implications for pharmacists in hospitals and health systems
Cobaugh, D. J., Gainor, C., Gaston, C. L., Kwong, T. C., Magnani, B., McPherson, M. L., Painter, J. T., & Krenzelok, E. P. (2014) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp140157 · Cited by 78
‘It's too much, I'm getting really tired of it’: Overdose response and structural vulnerabilities among harm reduction workers in community settings
Kolla, G., & Strıke, C. (2019) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2019.09.012 · Cited by 79
Barriers to naloxone use and acceptance among opioid users, first responders, and emergency department providers in New Hampshire, USA
Bessen, S. Y., Metcalf, S. A., Saunders, E. C., Moore, S. K., Meier, A., McLeman, B. M., Walsh, O., & Marsch, L. A. (2019) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2019.09.008 · Cited by 77
Preventing Opiate Overdose Deaths: Examining Objections to Take-Home Naloxone
Bazazi, A. R., Zaller, N. D., Fu, J. J., & Rich, J. D. (2010) · Journal of Health Care for the Poor and Underserved · doi:10.1353/hpu.2010.0935 · Cited by 73
Why is it so hard to implement change? A qualitative examination of barriers and facilitators to distribution of naloxone for overdose prevention in a safety net environment
Drainoni, M., Koppelman, E. A., Feldman, J. A., Walley, A. Y., Mitchell, P. M., Ellison, J. E., & Bernstein, E. (2016) · BMC Research Notes · doi:10.1186/s13104-016-2268-z · Cited by 73
Heroin-related overdose: The unexplored influences of markets, marketing and source-types in the United States
Mars, S. G., Fessel, J. N., Bourgois, P. I., Montero, F., Karandinos, G., & Ciccarone, D. (2015) · Social Science & Medicine · doi:10.1016/j.socscimed.2015.06.032 · Cited by 72
A response to the opioid overdose epidemic: Naloxone nasal spray
Wermeling, D. P. (2013) · Drug Delivery and Translational Research · doi:10.1007/s13346-012-0092-0 · Cited by 70
Naloxone's role in the national opioid crisis—past struggles, current efforts, and future opportunities
Bennett, A. S., & Elliott, L. C. (2021) · Translational research · doi:10.1016/j.trsl.2021.03.001 · Cited by 70
Cost-Effectiveness of Take-Home Naloxone for the Prevention of Overdose Fatalities among Heroin Users in the United Kingdom
Langham, S., Wright, A., Kenworthy, J., Grieve, R., & Dunlop, W. (2018) · Value in Health · doi:10.1016/j.jval.2017.07.014 · Cited by 70
Barriers to Medical Provider Support for Prescription Naloxone As Overdose Antidote for Lay Responders
Green, T. C., Bowman, S. E., Zaller, N. D., Ray, M., Case, P., & Heimer, R. (2013) · Substance Use & Misuse · doi:10.3109/10826084.2013.787099 · Cited by 67
The Emergency Department as an Opportunity for Naloxone Distribution
Gunn, A. H., Smothers, Z., Schramm‐Sapyta, N. L., Freiermuth, C. E., MacEachern, M., & Muzyk, A. J. (2018) · Western Journal of Emergency Medicine · doi:10.5811/westjem.2018.8.38829 · Cited by 64
Pharmacokinetic Properties of Intranasal and Injectable Formulations of Naloxone for Community use: a Systematic Review
Ryan, S. A., & Dunne, R. (2018) · Pain Management · doi:10.2217/pmt-2017-0060 · Cited by 67
The Bell Tolls for Thee & Thine: Compassion Fatigue & the Overdose Epidemic
Winstanley, E. L. (2020) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2020.102796 · Cited by 66
Stable Liquid Glucagon: Beyond Emergency Hypoglycemia Rescue
Wilson, L. M., & Castle, J. R. (2018) · Journal of Diabetes Science and Technology · doi:10.1177/1932296818757795 · Cited by 64
Preventing opioid overdose with peer-administered naloxone: findings from a rural state
Hanson, B. L., Porter, R. R., Zöld, A. L., & Terhorst-Miller, H. (2020) · Harm Reduction Journal · doi:10.1186/s12954-019-0352-0 · Cited by 62
Effect of Intranasal vs Intramuscular Naloxone on Opioid Overdose
Dietze, P., JAUNCEY, M. E., Salmon, A. M., Mohebbi, M., Latimer, J., van Beek, I., McGrath, C., & Kerr, D. C. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.14977 · Cited by 61
The Feasibility of Pharmacy-Based Naloxone Distribution Interventions: A Qualitative Study With Injection Drug Users and Pharmacy Staff in Rhode Island
Zaller, N. D., Yokell, M. A., Green, T. C., Gaggin, J., & Case, P. (2013) · Substance Use & Misuse · doi:10.3109/10826084.2013.793355 · Cited by 60
Brief overdose education can significantly increase accurate recognition of opioid overdose among heroin users
Jones, J. D., Roux, P., Stancliff, S., Matthews, W., & Comer, S. D. (2013) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2013.05.006 · Cited by 62
Neurocognitive impairments and brain abnormalities resulting from opioid-related overdoses: A systematic review
Winstanley, E. L., Mahoney, J. J., Castillo, F., & Comer, S. D. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.108838 · Cited by 66
Association between non-fatal opioid overdose and encounters with healthcare and criminal justice systems: Identifying opportunities for intervention
Wagner, K. D., Liu, L., Davidson, P. J., Cuevas-Mota, J., Armenta, R. F., & Garfein, R. S. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.05.026 · Cited by 57
Oxytocin under opioid antagonism leads to supralinear enhancement of social attention
Dal Monte, O., Piva, M., Anderson, K. M., Tringides, M., Holmes, A. J., & Chang, S. W. C. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702725114 · Cited by 55
How competent are people who use opioids at responding to overdoses? Qualitative analyses of actions and decisions taken during overdose emergencies
Neale, J., Brown, C., Campbell, A. N. C., Jones, J. D., Metz, V. E., Strang, J., & Comer, S. D. (2018) · Addiction · doi:10.1111/add.14510 · Cited by 55
Emergency department naloxone distribution: a Rhode Island department of health, recovery community, and emergency department partnership to reduce opioid overdose deaths.
Samuels, E. A. (2014) · PubMed · Cited by 55
Experiences of peer-trainers in a take-home naloxone program: Results from a qualitative study
Marshall, C., Perreault, M., Archambault, L., & Milton, D. (2016) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2016.11.015 · Cited by 58
Intranasal naloxone and related strategies for opioid overdose intervention by nonmedical personnel: a review
Lewis, C., Vo, H. T., & Fishman, M. J. (2017) · Substance Abuse and Rehabilitation · doi:10.2147/sar.s101700 · Cited by 54
Impacts of an opioid overdose prevention intervention delivered subsequent to acute care
Banta‐Green, C. J., Coffin, P. O., Merrill, J. O., Sears, J. M., Dunn, C. W., Floyd, A. S., Whiteside, L., Yanez, N. D., & Donovan, D. M. (2018) · Injury Prevention · doi:10.1136/injuryprev-2017-042676 · Cited by 53
Lay responder naloxone access and Good Samaritan law compliance: postcard survey results from 20 Indiana counties
Watson, D. P., Ray, B. R., Robison, L., Huynh, P., Sightes, E., Walker, L. S., Brucker, K., & Duwve, J. M. (2018) · Harm Reduction Journal · doi:10.1186/s12954-018-0226-x · Cited by 51
What is known about community pharmacy supply of naloxone? A scoping review
Nielsen, S., & Hout, M. C. V. (2016) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2016.02.006 · Cited by 51
Naloxone without the needle − systematic review of candidate routes for non-injectable naloxone for opioid overdose reversal
Strang, J., McDonald, R., Alqurshi, A. A., Royall, P. G., Taylor, D. M., & Forbes, B. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.02.042 · Cited by 51
Cost-effectiveness of distributing naloxone to heroin users for lay overdose reversal in Russian cities
Coffin, P. O., & Sullivan, S. D. (2013) · Journal of Medical Economics · doi:10.3111/13696998.2013.811080 · Cited by 50
Treating Addictions: Harm Reduction in Clinical Care and Prevention
Drucker, E., Anderson, K., Haemmig, R., Heimer, R., Small, D., Walley, A., Wood, E., & van Beek, I. (2016) · Journal of Bioethical Inquiry · doi:10.1007/s11673-016-9720-6 · Cited by 49
Incidence of Naloxone Redosing in the Age of the New Opioid Epidemic
Klebacher, R., Harris, M. I., Ariyaprakai, N., Tagore, A., Robbins, V., Dudley, L. S., Bauter, R., Koneru, S., Hill, R. D., Wasserman, E., et al. (2017) · Prehospital Emergency Care · doi:10.1080/10903127.2017.1335818 · Cited by 52
Expanded Access to Opioid Overdose Intervention: Research, Practice, and Policy Needs
Compton, W. M., Volkow, N. D., Throckmorton, D. C., & Lurie, P. G. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-1-201301010-00013 · Cited by 48
How do naloxone-based interventions work to reduce overdose deaths: a realist review
Miller, N., Waterhouse‐Bradley, B., Campbell, C., & Shorter, G. W. (2022) · Harm Reduction Journal · doi:10.1186/s12954-022-00599-4 · Cited by 43
Development and Implementation of an Opioid Overdose Prevention and Response Program in Toronto, Ontario
Leece, P., Hopkins, S., Marshall, C., Orkin, A. M., Gassanov, M. A., & Shahin, R. (2013) · Canadian Journal of Public Health · doi:10.17269/cjph.104.3788 · Cited by 44
Law Enforcement Attitudes towards Naloxone following Opioid Overdose Training
Purviance, D., Ray, B. R., Tracy, A., & Southard, E. P. (2016) · Substance Abuse · doi:10.1080/08897077.2016.1219439 · Cited by 44
Prescribing Naloxone for Opioid Overdose Intervention
Dunne, R. (2018) · Pain Management · doi:10.2217/pmt-2017-0065 · Cited by 45
Pharmacokinetics of a new, nasal formulation of naloxone
Tylleskär, I., Skulberg, A. K., Nilsen, T., Skarra, S., Jansook, P., & Dale, O. (2017) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-016-2191-1 · Cited by 41
The introduction of fentanyl on the US–Mexico border: An ethnographic account triangulated with drug checking data from Tijuana
Friedman, J. R., Bourgois, P. I., Godvin, M., Chavez, A., Pacheco, L., Segovia, L. A., Beletsky, L. A., & Arredondo, J. (2022) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2022.103678 · Cited by 43
Wasted, overdosed, or beyond saving – To act or not to act? Heroin users’ views, assessments, and responses to witnessed overdoses in Malmö, Sweden
Richert, T. (2014) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2014.07.006 · Cited by 41
Expanding access to naloxone in the United States
Doyon, S., Aks, S. E., & Schaeffer, S. E. (2014) · Clinical Toxicology · doi:10.3109/15563650.2014.968657 · Cited by 40
A systematic review of strategies to improve appropriate use of opioids and to reduce opioid use disorder and deaths from prescription opioids
Furlan, A. D., Carnide, N., Irvin, E., Eerd, D. V., Munhall, C., Kim, J., Li, C. M. F., Hamad, A. H., Mahood, Q., & MacDonald, S. (2018) · Canadian Journal of Pain · doi:10.1080/24740527.2018.1479842 · Cited by 39

Authors: Doe-Simkins, M., Walley, A. Y., Epstein, A., & Moyer, P.
Affiliations: Boston University (US)
ORCID: Doe-Simkins, Maya
Walley, Alexander Y.
Venue: American Journal of Public Health
Publisher: American Public Health Association
Published: 2009-05
Volume: 99
Issue: 5
Pages: 788-791
ISSN: 0090-0036 (ISSN-L)
1541-0048
DOI: 10.2105/ajph.2008.146647
PMC: PMC2667836
OpenAlex: W2160243203
Cited by: 250
References: 25
Citations by year: 2026: 5 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 19 · 2021: 20 · 2020: 13 · 2019: 17 · 2018: 20 · 2017: 19 · 2016: 25 · 2015: 22 · 2014: 22 · 2013: 14 · 2012: 9
FWCI: 9.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Public Health (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
Keywords: intranasal naloxone, opioid overdose, overdose reversal, bystander intervention, public health regulation, harm reduction, opioid use disorder
MeSH terms: Administration, Intranasal, Adult, Emergency Medical Services, Female, Humans, Male, Naloxone, Narcotic Antagonists, Opioid-Related Disorders, Risk Factors, Program Evaluation, Needle-Exchange Programs, Drug Overdose

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Saved by the Nose: Bystander-Administered Intranasal Naloxone Hydrochloride for Opioid Overdose

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks