The DOI matches its Crossref record.
Long-term pain control by direct peripheral-nerve stimulation.
Abstract
In 1970, we began implanting electrodes for prolonged stimulation of injured peripheral nerves to reduce chronic pain. Thirty-eight peripheral nerves in thirty-five patients have been stimulated with electrodes for a period ranging from four to nine years. Nineteen electrode systems were implanted in the upper extremity (eleven on the median nerve, six on the ulnar nerve, one on the median and ulnar nerves, and one on the median and radial nerves), with successful relief of pain in 52..6 per cent of the patients. Sixteen stimulators have been implanted on the sciatic nerve with a success rate for pain relief of 31 per cent. Failures in the lower extremity were found primarily in lesions of the posterior tibial nerve at the ankle. We speculate that the stress of weight-bearing and the anatomical position of the posterior tibial nerve may partially account for this rate of failure. Use of the electrode-implant systems required careful preoperative assessment by an experienced team, meticulous technique, and a mechanical system that tolerates stress. The location and characteristics of the lesion affect the response to electrical stimulation.
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In the citing paper
“for reducing pain”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Nashold et al., 1982
In the citing paper
“up to 8 years stimulating the median, radial, sciatic, and ulnar nerves [39]”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [39]
Citations
Cited by
Sorted by citations
Navarro, X., Krueger, T. B., Lago, N., Micera, S., Stieglitz, T., & Dario, P. (2005) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2005.10303.x · Cited by 845
“, 1997), for reducing pain (Nashold et al., 1982; Strege et al., 1994; StantonHicks and Salamon, 1997), for phrenic nerve pacing for ventilatory assistance (Glenn et al.”
BackgroundA spiral nerve cuff electrode for peripheral nerve stimulation
Naples, G. G., Mortimer, J. T., Scheiner, A., & Sweeney, J. D. (1988) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.8670 · Cited by 415
Postamputation pain: epidemiology, mechanisms, and treatment
Cohen, S. P., & Hsu (2013) · Journal of Pain Research · doi:10.2147/jpr.s32299 · Cited by 381
Peripheral nerve stimulation for neuropathic pain
Slavin, K. (2011) · Neurotherapeutics · doi:10.1016/j.nurt.2007.11.005 · Cited by 199
“long-term success rate of 25%, and in 1982, Nashold et al.(24) reported successful outcomes in 53% of patients”
BackgroundSafety of long-term electrical peripheral nerve stimulation: review of the state of the art
Günter, C., Delbeke, J., & Ortiz-Catalan, M. (2019) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-018-0474-8 · Cited by 198
“Similar compatibility was shown for up to 18 years stimulating the phrenic nerve [5]; up to 8 years stimulating the median, radial, sciatic, and ulnar nerves [39]; and up to 11 years stimulating motor and sensory nerves in a feedback controlled application [26].”
Method
Metadata
- Authors
- Nashold, B. S., Goldner, J. L., Mullen, J. B., & Bright, D. S.
- Venue
- The Journal of Bone & Joint Surgery
- Published
- 1982-01
- Volume
- 64
- Issue
- 1
- Pages
- 1-10
- ISSN
- 0021-9355 (ISSN-L)
- OpenAlex
- W1907072860
- Cited by
- 184
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 12 · 2012: 10
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Bone and Joint Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- peripheral nerve stimulation, chronic pain, peripheral nerve injury, median nerve, ulnar nerve, sciatic nerve, posterior tibial nerve, electrode implantation, analgesia, implant failure
- MeSH terms
- Adult, Aged, Electrodes, Implanted, Electric Stimulation Therapy, Female, Follow-Up Studies, Humans, Male, Median Nerve, Middle Aged, Nerve Block, Intractable Pain, Sciatic Nerve, Ulnar Nerve, Peripheral Nerve Injuries
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