The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
The Use of Alendronate to Prevent Early Collapse of the Femoral Head in Patients with Nontraumatic Osteonecrosis<sbt aid="959764">A Randomized Clinical Study</sbt>
Abstract
BACKGROUND: Osteonecrosis of the femoral head is the most common diagnosis leading to total hip arthroplasty in young adults. Joint-preserving treatment options have been mainly surgical, with inconsistent results. Alendronate (a bisphosphonate agent) has been shown to lower the prevalence of vertebral compression fractures and could potentially retard the collapse of an osteonecrotic femoral head. The purpose of this study was to test the effect of alendronate in preventing early collapse of the femoral head in patients with nontraumatic osteonecrosis. METHODS: Forty patients with Steinberg stage-II or III nontraumatic osteonecrosis of the femoral head and a necrotic area of >30% (class C) were randomly divided into alendronate and control groups of twenty patients each. Patients in the alendronate group took 70 mg of alendronate orally per week for twenty-five weeks, while the patients in the control group did not receive this medication or a placebo. The patients were observed for a minimum of twenty-four months. Harris hip scores, plain radiographs, and magnetic resonance imaging scans were obtained. RESULTS: During the study period, only two of twenty-nine femoral heads in the alendronate group collapsed, whereas nineteen of twenty-five femoral heads in the control group collapsed (p < 0.001). One hip in the alendronate group underwent total hip arthroplasty, whereas sixteen hips in the control group underwent total hip arthroplasty (p < 0.001). CONCLUSIONS: Alendronate appeared to prevent early collapse of the femoral head in the hips with Steinberg stage-II or IIIC nontraumatic osteonecrosis. A longer duration of follow-up is needed to confirm whether alendronate prevents or only retards collapse. LEVEL OF EVIDENCE: Therapeutic Level I.
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Cites
Ten Years' Experience with Alendronate for Osteoporosis in Postmenopausal Women
Bone, H. G., Hosking, D., Devogelaer, J.-P., Tucci, J. R., Emkey, R. D., Tonino, R. P., Rodriguez-Portales, J. A., Downs, R. W., Gupta, J., Santora, A. C., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa030897 · Cited by 1,347
Non-traumatic avascular necrosis of the femoral head.
Mont, M. A., & Hungerford, D. S. (1995) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-199503000-00018 · Cited by 1,191
Bisphosphonates: mechanisms of action.
Rodan, G. A., & Fleisch, H. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118722 · Cited by 921
Core Decompression Versus Nonoperative Management for Osteonecrosis of the Hip
Mont, M. A., Carbone, J. J., & Fairbank, A. C. (1996) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199603000-00020 · Cited by 527
The Management of Fresh Ruptures of the Tendo Achillis
Gillies, H., & Chalmers, J. A. C. (1970) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197052020-00015 · Cited by 438
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Quantifying the extent of osteonecrosis of the femoral head. A new method using MRI
Koo, K., & Kim, R. (1995) · The Journal of Bone and Joint Surgery. British volume · doi:10.1302/0301-620x.77b6.7593098 · Cited by 217
Core decompression of the femoral head for osteonecrosis.
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Cited by
Liu, D., Ahmet, A., Ward, L., Krishnamoorthy, P., Mandelcorn, E. D., Leigh, R., Brown, J. P., Cohen, A., & Kim, H. (2013) · Allergy, Asthma & Clinical Immunology · doi:10.1186/1710-1492-9-30 · Cited by 1,268
Nontraumatic Osteonecrosis of the Femoral Head
Mont, M. A., Smitterberg, C. W., Jones, L. C., Goodman, S. B., Lieberman, J. R., Parvizi, J., & Cheng, E. Y. (2006) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.25.01621 · Cited by 537
Bisphosphonates: Mode of Action and Pharmacology
Russell, R. G. G. (2007) · Pediatrics · doi:10.1542/peds.2006-2023h · Cited by 503
Glucocorticoid-induced osteonecrosis
Weinstein, R. S. (2012) · Endocrine · doi:10.1007/s12020-011-9580-0 · Cited by 428
Bisphosphonates: An Update on Mechanisms of Action and How These Relate to Clinical Efficacy
RUSSELL, R. G. G., XIA, Z., DUNFORD, J. E., OPPERMANN, U., KWAASI, A., HULLEY, P. A., KAVANAGH, K. L., TRIFFITT, J. T., LUNDY, M. W., PHIPPS, R. J., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.089 · Cited by 391
Metadata
- Authors
- Lai, K.-A.
- Venue
- The Journal of Bone and Joint Surgery (American)
- Published
- 2005-10-01
- Volume
- 87
- Issue
- 10
- Pages
- 2155
- ISSN
- 0021-9355 (ISSN-L)
- OpenAlex
- W2003745782
- Cited by
- 332
- References
- 19
- FWCI
- 20.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lai, K.-A. (2005). The Use of Alendronate to Prevent Early Collapse of the Femoral Head in Patients with Nontraumatic Osteonecrosis<sbt aid="959764">A Randomized Clinical Study</sbt>. The Journal of Bone and Joint Surgery (American). https://doi.org/10.2106/jbjs.d.02959
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