The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
Abstract
Nanomaterials of carbon origin tend to form various shapes of particles in micrometer dimensions. Among them, multi-wall carbon nanotubes (MWCNT) form fibrous or rod-shaped particles of length around 10 to 20 micrometers with an aspect ratio of more than three. Fibrous particles of this dimension including asbestos and some man-made fibers are reported to be carcinogenic, typically inducing mesothelioma. Here we report that MWCNT induces mesothelioma along with a positive control, crocidolite (blue asbestos), when administered intraperitoneally to p53 heterozygous mice that have been reported to be sensitive to asbestos. Our results point out the possibility that carbon-made fibrous or rod-shaped micrometer particles may share the carcinogenic mechanisms postulated for asbestos. To maintain sound activity of industrialization of nanomaterials, it would be prudent to implement strategies to keep good control of exposure to fibrous or rod-shaped carbon materials both in the workplace and in the future market until the biological/ carcinogenic properties, especially of their long-term biodurability, are fully assessed.
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Hydroxyl radical production in the presence of fibres by a fenton-type reaction
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Cited by
Nagai, H., Okazaki, Y., Chew, S. H., Misawa, N., Yamashita, Y., Akatsuka, S., Ishihara, T., Yamashita, K., Yoshikawa, Y., Yasui, H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110013108 · Cited by 535
Potential Health Impact of Nanoparticles
Xia, T., Li, N., & Nel, A. E. (2009) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.031308.100155 · Cited by 432
Pacurari, M., Yin, X. J., Zhao, J., Ding, M., Leonard, S. S., Schwegler-Berry, D., Ducatman, B. S., Sbarra, D., Hoover, M. D., Castranova, V., et al. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10924 · Cited by 372
A Predictive Toxicological Paradigm for the Safety Assessment of Nanomaterials
Meng, H., Xia, T., George, S., & Nel, A. E. (2009) · ACS Nano · doi:10.1021/nn9005973 · Cited by 344
Sakamoto, Y., Nakae, D., Fukumori, N., Tayama, K., Maekawa, A., Imai, K., Hirose, A., Nishimura, T., Ohashi, N., & Ogata, A. (2009) · The Journal of Toxicological Sciences · doi:10.2131/jts.34.65 · Cited by 320
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Metadata
- Authors
- Takagi, A., Hirose, A., Nishimura, T., Fukumori, N., Ogata, A., Ohashi, N., Kitajima, S., & Kanno, J.
- Venue
- The Journal of Toxicological Sciences
- Publisher
- Japanese Society of Toxicology
- Published
- 2008
- Volume
- 33
- Issue
- 1
- Pages
- 105-116
- ISSN
- 0388-1350 (ISSN-L)
- 1880-3989
- OpenAlex
- W2119538646
- Cited by
- 834
- References
- 4
- FWCI
- 74.01
- Type
- journal article
- Language
- en
- Open access
- closed
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