The possible role of squalene and its peroxide of the sebum in the occurrence of sunburn and protection from the damage caused by U.V. irradiation.
Open accessAbstract
To clarify the role of squalene peroxide in the occurrence of skin damage from sunburn, the optimum condition of squalene peroxidation and the effect of squalene peroxide on cutaneous tissue were examined. Peroxidation of squalene was more easily induced than palmitoleic acid and oleic acid in the unsaturated lipid occurred in sebum. The peroxidation of squalene gradually occurred by U.V. irradation, and it is parallel to increases in the malonyldialdehyde production (production of lipoperoxide). This peroxidation easily carries out in the case of high temperature (40 degrees C than 30 degrees C), and in the case of low pH. Good correspondence was recognized among the spectrum of natural daylight, U.V. absorption spectrum of squalene and erythema curve. Squalene and its peroxide have an important role in the occurrence of sunburn, and/or protection from damage caused by U.V. irradiation.
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Squalene neutralizes the formation of UV irradiation-induced reactive oxygen species in the skin.
“Due to its prominent lubricant and penetration efficiency squalene is capable of neutralizing the formation of UV irradiation-induced reactive oxygen species in the skin.6,7”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [6]
The Discussion (p. 8) proposes that squalene protects the skin surface by trapping UV energy through peroxidation. It does not say that squalene neutralizes the formation of reactive oxygen species; the Results (p. 4) instead report increased squalene oxidation after UV irradiation. The cited paper also does not attribute this effect to lubricant or penetration efficiency. (LLM, conf=0.84)
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Research works printed but not linked: 1
- Kligman, A. M. (1963): Advances in biology of skin, Vol.4, The sebaceous glands, Ed. by Montagna, W., Pergamon Press, p. 110.
Cited by
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Sebaceous-immunobiology is orchestrated by sebum lipids
Lovászi, M., Szegedi, A., Zouboulis, C. C., & Törőcsik, D. (2017) · Dermato-Endocrinology · doi:10.1080/19381980.2017.1375636 · Cited by 151 · see citing works
“Due to its prominent lubricant and penetration efficiency squalene is capable of neutralizing the formation of UV irradiation-induced reactive oxygen species in the skin.(6,7) On the other hand, peroxidated squalene along with unsaturated free fatty acids (FFA), has been reported to be comedogenic and therefore respon…”
BackgroundPham, D. ‐., Boussouira, B., Moyal, D., & Nguyen, Q. L. (2015) · International Journal of Cosmetic Science · doi:10.1111/ics.12208 · Cited by 89 · see citing works
Role of skin surface lipids in UV-induced epidermal cell changes
Picardo, M., Zompetta, C., De Luca, C., Cirone, M., Faggioni, A., Nazzaro-Porro, M., Passi, S., & Prota, G. (1991) · Archives of Dermatological Research · doi:10.1007/bf00372061 · Cited by 58 · see citing works
Cho, S., Choi, C.-W., Lee, D. H., Won, C.-H., Kim, S. M., Lee, S., Lee, M.-J., & Chung, J. H. (2009) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2008.03133.x · Cited by 35 · see citing works
- Authors
- OHSAWA, K., WATANABE, T., MATSUKAWA, R., YOSHIMURA, Y., & IMAEDA, K.
- ORCID
- YOSHIMURA, Yoshihiro
- Venue
- The Journal of Toxicological Sciences
- Publisher
- Japanese Society of Toxicology
- Published
- 1984
- Volume
- 9
- Issue
- 2
- Pages
- 151-159
- ISSN
- 0388-1350 (ISSN-L)
- 1880-3989
- OpenAlex
- W2026957983
- Cited by
- 63
- References
- 0
- Citations by year
- 2025: 3 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 4 · 2017: 5 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Toxicological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- squalene, sebum, sunburn, UV irradiation, skin damage, lipid peroxidation, malondialdehyde, erythema, unsaturated lipids, UV absorption spectrum, photoprotection
- MeSH terms
- Animals, Guinea Pigs, Hydrogen-Ion Concentration, Lipid Peroxides, Male, Oxygen Consumption, Sebum, Skin, Squalene, Sunburn, Ultraviolet Rays, Vitamin E
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