Role of skin surface lipids in UV-induced epidermal cell changes
Abstract
Ultraviolet irradiation is capable of affecting skin surface lipids, especially squalene and cholesterol, both in vitro and in vivo, with generation of active lipoperoxides. The photodecomposition of the skin lipid component was carefully evaluated by capillary gas-chromatography. The effects of UV-induced lipoperoxides on human keratinocytes in culture and on guinea pig ear slices were compared with those of synthetic lipoperoxides, i.e. cumene hydroperoxide and 13-hydroperoxylinoleate. A time- and dose-dependent effect on protein synthesis and mitotic activity was observed. In cell culture low concentrations (0.05-5 micrograms/ml) of peroxidated squalene and synthetic lipoperoxides stimulated the incorporation of radiolabelled thymidine and phenylalanine, while higher concentrations (greater than 10 micrograms/ml), or longer periods of treatment, induced cellular damage. In guinea pig ear slices, the lipoperoxides (5-50 micrograms/ml) increased aminoacid incorporation and the number of epidermal pigment cells; higher concentrations (greater than 100 micrograms/ml) caused a derangement of epidermal structure. The results suggest that UV irradiation of skin generates lipoperoxides from the surface lipids which, in vitro, are capable of producing a number of changes in epidermal cells.
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Squalene neutralizes the formation of UV irradiation-induced reactive oxygen species in the skin.
“Due to its prominent lubricant and penetration efficiency squalene is capable of neutralizing the formation of UV irradiation-induced reactive oxygen species in the skin.6,7”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [7]
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“Due to its prominent lubricant and penetration efficiency squalene is capable of neutralizing the formation of UV irradiation-induced reactive oxygen species in the skin.(6,7) On the other hand, peroxidated squalene along with unsaturated free fatty acids (FFA), has been reported to be comedogenic and therefore respon…”
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- Authors
- Picardo, M., Zompetta, C., De Luca, C., Cirone, M., Faggioni, A., Nazzaro-Porro, M., Passi, S., & Prota, G.
- Affiliations
- San Gallicano Hospital (IT)
- Sapienza University of Rome (IT)
- Venue
- Archives of Dermatological Research
- Published
- 1991-05
- Volume
- 283
- Issue
- 3
- Pages
- 191-197
- ISSN
- 0003-9187 (ISSN-L)
- 0340-3696
- 1432-069X
- OpenAlex
- W2052259078
- Cited by
- 58
- References
- 34
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2015: 2 · 2014: 1 · 2013: 2
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Dermatological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- UV irradiation, skin surface lipids, squalene, cholesterol, lipid hydroperoxides, cumene hydroperoxide, human keratinocytes, epidermal cells, protein synthesis, mitotic activity, epidermal pigmentation, epidermal structure, photolysis
- MeSH terms
- Epidermal Cells, Adult, Animals, Cells, Cultured, Chromatography, Gas, Dose-Response Relationship, Drug, Epidermis, Guinea Pigs, Humans, Lipid Peroxides, Male, Membrane Lipids, Middle Aged, Skin, Time Factors, Ultraviolet Rays, Lipid Peroxidation, Keratinocytes
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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