Plasma myeloperoxidase is related to the severity of coronary artery disease
Abstract
OBJECTIVE: It has been shown that the main apolipoprotein of HDL, Apo A-1, is subjected to nitration by myeloperoxidase (MPO) and this oxidative modification renders HDL proatherogenic. The aim of this study is to evaluate the relationship between plasma MPO levels, and the severity of coronary artery disease. METHODS AND RESULTS: Forty-eight patients with coronary artery narrowing and 30 control subjects were enrolled in this study. The severity of the disease was assessed by Gensini scoring after angiography. MPO concentrations were determined by using an enzyme immunoassay. A subgroup of 30 patients underwent computerized tomography to determine the calcium load of coronary arteries. Plasma MPO levels were found significantly higher in patients with coronary artery disease than controls (4.27 [1.60 to 42.43] ng/mL vs. 2.93 [1.00 to 9.25] ng/mL, P = 0.002). MPO was positively correlated with both Gensini (r = 0.228, P = 0.044) and coronary calcium scores (r = 0.433, P = 0.017). The atherosclerotic burden was more strongly correlated with MPO levels than the traditional markers such as total cholesterol and HDL. CONCLUSIONS: We found that MPO levels were elevated in patients with coronary artery disease and this increase correlated with the extent and severity of atherosclerosis. Although it is a preliminary study with a relatively small group of subjects, we suggest that MPO might be evaluated as a new marker indicating the presence and severity of coronary artery disease.
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Several studies have correlated low circulating MPO levels with better cardiovascular prognosis.
“Several studies have correlated low circulating MPO levels with better cardiovascular prognosis (239, 260, 644, 690, 1059).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [260]
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- Authors
- Düzgünçinar, Ö., Yavuz, B., Hazirolan, T., Deniz, A., Tokgözoglu, S. L., Akata, D., & Demirpençe, E.
- Affiliations
- Hacettepe University (TR)
- Venue
- Acta Cardiologica
- Publisher
- Peeters Publishers
- Published
- 2008-04-01
- Volume
- 63
- Issue
- 2
- Pages
- 147-152
- ISSN
- 0001-5385 (ISSN-L)
- OpenAlex
- W1970602978
- Cited by
- 54
- References
- 28
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 3
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Cardiologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- myeloperoxidase, coronary artery disease, disease severity, atherosclerosis, coronary artery calcium score, Gensini score, HDL oxidation, oxidative stress, biomarkers
- MeSH terms
- Calcium, Coronary Vessels, Enzyme-Linked Immunosorbent Assay, Follow-Up Studies, Humans, Middle Aged, Peroxidase, Prognosis, Severity of Illness Index, Biomarkers, Coronary Angiography, Coronary Stenosis, Tomography, Spiral Computed
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