Genes associated with Alzheimer's disease: an overview and current status

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease

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Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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Alzheimer’s disease

Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134

TREM2 Variants in Alzheimer's Disease

Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Initiative, T. A. D. N., Hollingworth, P., CHARGE consortium, EADI1 consortium, Harold, D., Sims, R., Gerrish, A., Lambert, J.-C., Carrasquillo, M. M., Abraham, R., et al. (2011) · Nature Genetics · doi:10.1038/ng.803 · Cited by 1,997

PLD3 epigenetic changes in the hippocampus of Alzheimer’s disease

Blanco‐Luquin, I., Altuna, M., de Gordoa, J. S., Urdánoz‐Casado, A., Roldán, M., Cámara, M. S., Zelaya, M. V., Erro, M. E., Echávarri, C., & Mendióroz, M. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0547-3 · Cited by 30

The interplay between aging‐associated loss of protein homeostasis and extracellular vesicles in neurodegeneration

Guix, F. X. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24526 · Cited by 30

Multiplexing Biomarker Methods, Proteomics and Considerations for Alzheimer’s Disease

Robinson, R. A. S., Amin, B., & Guest, P. C. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-52479-5_2 · Cited by 29

Alzheimer's disease in the gut—Major changes in the gut of 5xFAD model mice with ApoA1 as potential key player

Stoye, N. M., Guilherme, M. D. S., & Endres, K. (2020) · The FASEB Journal · doi:10.1096/fj.201903128rr · Cited by 30

Gene mutations associated with early onset familial Alzheimer’s disease in China: An overview and current status

Qin, Q., Yin, Y., Wang, Y., Lu, Y., Tang, Y., & Jia, J. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1443 · Cited by 28

Current therapeutics for Alzheimer’s disease and clinical trials

Xiao, D., & Zhang, C. (2024) · Exploration of Neuroscience · doi:10.37349/en.2024.00048 · Cited by 30

Drugs targeting APOE4 that regulate beta‐amyloid aggregation in the brain: Therapeutic potential for Alzheimer's disease

Poblano, J., Castillo‐Tobías, I., Berlanga, L., Tamayo‐Ordoñez, M. C., Rodríguez‐Salazar, M. D. C., Silva‐Belmares, S. Y., Aguayo‐Morales, H., & Cobos-Puc, L. E. (2024) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.14055 · Cited by 29

Into the Fourth Dimension: Dysregulation of Genome Architecture in Aging and Alzheimer’s Disease

Winick‐Ng, W., & Rylett, R. J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00060 · Cited by 28

ABCA7 risk variant in healthy older African Americans is associated with a functionally isolated entorhinal cortex mediating deficient generalization of prior discrimination training

Sinha, N., Reagh, Z. M., Tustison, N. J., Berg, C. N., Shaw, A., Myers, C. E., Hill, D., Yassa, M. A., & Gluck, M. A. (2018) · Hippocampus · doi:10.1002/hipo.23042 · Cited by 25

Application of Artificial Intelligence and Machine Learning Techniques in Classifying Extent of Dementia Across Alzheimer's Image Data

Ghosh, R., Cingireddy, A. R., Melapu, V. K., Joginipelli, S., & Kar, S. (2021) · International Journal of Quantitative Structure-Property Relationships · doi:10.4018/ijqspr.2021040103 · Cited by 25

Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders

Khatri, D. K., Kadbhane, A., Patel, M., Nene, S., Atmakuri, S., Srivastava, S., & Singh, S. B. (2021) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2021.100022 · Cited by 25

Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention

Lu, Q., Yu, A., Pu, J., Chen, D., Zhong, Y., Bai, D., & Yang, L. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1375973 · Cited by 27

Recent Advances in the Systems Biology of Aging

McCormick, M. A., & Promislow, D. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7367 · Cited by 25

Common aspects between glaucoma and brain neurodegeneration

Saccà, S. C., Paluan, F., Gandolfi, S., Manni, G., Cutolo, C. A., & Izzotti, A. (2020) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2020.108323 · Cited by 25

Spatially resolved mass spectrometry analysis of amyloid plaque‐associated lipids

Blank, M., & Hopf, C. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15216 · Cited by 24

Brief Report

Virk, S. A., & Eslick, G. D. (2015) · Epidemiology · doi:10.1097/ede.0000000000000326 · Cited by 24

Clinical relevance of biomarkers, new therapeutic approaches, and role of post-translational modifications in the pathogenesis of Alzheimer’s disease

Mumtaz, I., Ayaz, M. O., Khan, M. S., Manzoor, U., Ganayee, M. A., Bhat, A. Q., Dar, G. H., Alghamdi, B. S. A., Hashem, A. M., Dar, M. J., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.977411 · Cited by 23

Unveiling tomorrow: Carbonic anhydrase activators and inhibitors pioneering new frontiers in Alzheimer's disease

Mishra, K. A., & Sethi, K. K. (2024) · Archiv der Pharmazie · doi:10.1002/ardp.202400748 · Cited by 21

Dysregulated gene-associated biomarkers for Alzheimer’s disease and aging

Li, M., Geng, R., Li, C., Meng, F., Zhao, H., Liu, J., Dai, J., & Wang, X. (2021) · Translational Neuroscience · doi:10.1515/tnsci-2021-0009 · Cited by 19

Formulation strategies for nose-to-brain drug delivery in Alzheimer's disease

Vohra, M., Amir, M., Sharma, A., & Wadhwa, S. (2023) · Health Sciences Review · doi:10.1016/j.hsr.2023.100075 · Cited by 21

Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus

Weiner, S., Junkkari, A., Sauer, M., Luikku, A. J., Rauramaa, T. H., Kokkola, T., Herukka, S., Blennow, K., Zetterberg, H., Leinonen, V., et al. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00440-5 · Cited by 21

Association Between Common Variants of APOE , ABCA7 , A2M , BACE1 , and Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease: Data from the PUMCH Dementia Cohort

Dong, L., Mao, C., Liu, C., Li, J., Huang, X., Wang, J., Lei, D., Chu, S., Sha, L., Xu, Q., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215067 · Cited by 21

Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox

Ontario, M. L., Siracusa, R., Modafferi, S., Scuto, M. C., Sciuto, S., Greco, V., Bertuccio, M. P., Salinaro, A. T., Crea, R., Calabrese, E. J., et al. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111637 · Cited by 20

Novel Psychoactive Substances: The Razor’s Edge between Therapeutical Potential and Psychoactive Recreational Misuse

Correia, B., Fernandes, J., Botica, M. J., Ferreira, C., & Quintas, A. (2022) · Medicines · doi:10.3390/medicines9030019 · Cited by 23

Preclinical Alzheimer’s dementia: a useful concept or another dead end?

Mark, R. E., & Brehmer, Y. (2022) · European Journal of Ageing · doi:10.1007/s10433-022-00735-w · Cited by 20

Role of the adhesion molecule F3/Contactin in synaptic plasticity and memory

Gulisano, W., Bizzoca, A., Gennarini, G., Palmeri, A., & Puzzo, D. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.12.003 · Cited by 21

Stress-Induced NLRP3 Inflammasome in Human Diseases

Alcocer‐Gómez, E., Castejón‐Vega, B., & Cordero, M. D. (2017) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2017.02.002 · Cited by 19

Pathogenesis, Animal Models, and Drug Discovery of Alzheimer’s Disease

Xia, Z.-D., Ma, R.-X., Wen, J.-F., Zhai, Y.-F., Wang, Y.-Q., Wang, F.-Y., Liu, D., Zhao, X.-L., Sun, B., Jia, P., et al. (2023) · Journal of Alzheimer's Disease · doi:10.3233/jad-230326 · Cited by 19

Association of Lipidomics Signatures in Blood with Clinical Progression in Preclinical and Prodromal Alzheimer’s Disease

Sakr, F., Initiative, A. D. N., Dyrba, M., Bräuer, A., & Teipel, S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201504 · Cited by 19

Phytochemicals as therapeutic interventions in neurodegenerative diseases

Kavitha, R. V., Kumar, J. R., Egbuna, C., & Ifemeje, J. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817890-4.00010-x · Cited by 19

MicroRNA-Target Interaction Regulatory Network in Alzheimer’s Disease

Turk, A., Kunej, T., & Peterlin, B. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11121275 · Cited by 20

Natural Bioactive Products and Alzheimer’s Disease Pathology: Lessons from Caenorhabditis elegans Transgenic Models

Navarro‐Hortal, M. D., Romero‐Márquez, J. M., Osta, S., Jiménez-Trigo, V., Muñoz-Ollero, P., & Varela‐López, A. (2022) · Diseases · doi:10.3390/diseases10020028 · Cited by 18

Etiology, pathogenesis of Alzheimer's disease and amyloid beta hypothesis

Kamble, S. M., Patil, K. R., & Upaganlawar, A. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13205-6.00022-4 · Cited by 18

Inference of Causative Genes for Alzheimer’s Disease Due to Dosage Imbalance

Sekine, M., & Makino, T. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx183 · Cited by 18

Lessons on Differential Neuronal-Death-Vulnerability from Familial Cases of Parkinson’s and Alzheimer’s Diseases

Franco, R., Navarro, G., & Martínez‐Pinilla, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133297 · Cited by 17

The nickel-chelator dimethylglyoxime inhibits human amyloid beta peptide in vitro aggregation

Benoit, S. L., & Maier, R. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-86060-1 · Cited by 18

Single Nucleotide Polymorphism rs11136000 of CLU Gene (Clusterin, ApoJ) and the Risk of Late-Onset Alzheimer’s Disease in a Central European Population

Balcar, V. J., Zeman, T., Janout, V., Janoutová, J., Lochman, J., & Šerý, O. (2021) · Neurochemical Research · doi:10.1007/s11064-020-03176-y · Cited by 17

Association of Lipidomics Signatures in Blood with Clinical Progression in Preclinical and Prodromal Alzheimer's Disease.

Sakr, F. A., Dyrba, M., Bräuer, A. U., Teipel, S. J., & Initiative, A. D. N. (2022) · DZNE Pub · Cited by 17

Extracellular Vesicles in Psychiatry Research in the Context of RDoC Criteria

Ilgın, C., & Topuzoǧlu, A. (2018) · Psychiatry Investigation · doi:10.30773/pi.2018.09.17 · Cited by 17

A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases

Zhao, J., Zhu, M., Kumar, M., Ngo, F. Y., Li, Y., Lao, L., & Rong, J. (2018) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527317666181105093834 · Cited by 17

Cortex metabolome and proteome analysis reveals chronic arsenic exposure via drinking water induces developmental neurotoxicity through hnRNP L mediated mitochondrial dysfunction in male rats

Du, X., Luo, L., Huang, Q., & Zhang, J. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153325 · Cited by 17

Exploring the mechanistic insights of Cas scaffolding protein family member 4 with protein tyrosine kinase 2 in Alzheimer’s disease by evaluating protein interactions through molecular docking and dynamic simulations

Hassan, M., Shahzadi, S., Alashwal, H., Zaki, N., Seo, S., & Moustafa, A. A. (2018) · Neurological Sciences · doi:10.1007/s10072-018-3430-2 · Cited by 17

Circulating Exosomes from Alzheimer’s Disease Suppress Vascular Endothelial-Cadherin Expression and Induce Barrier Dysfunction in Recipient Brain Microvascular Endothelial Cell

Bei, J., Miranda-Morales, E. G., Gan, Q., Qiu, Y., Husseinzadeh, S., Liew, J. Y., Chang, Q., Krishnan, B., Gaitas, A., Yuan, S., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230347 · Cited by 18

Pharmacogenomics for neurodegenerative disorders - a focused review

Ahmad, S. R., Zeyaullah, M., Khan, M. S. A. A., AlShahrani, A. M., Altijani, A. A. G., Ali, H., Dawria, A., Mohieldin, A., Alam, M. S., & Mohamed, A. O. A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1478964 · Cited by 17

Robust Sampling of Defective Pathways in Alzheimer’s Disease. Implications in Drug Repositioning

Fernández‐Martínez, J. L., Álvarez-Machancoses, Ó., deAndrés‐Galiana, E. J., Bea, G., & Kloczkowski, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103594 · Cited by 16

Endosomal sorting drives the formation of axonal prion protein endoggresomes

Chassefeyre, R., Chaiamarit, T., Verhelle, A., Novak, S. W., de Andrade, L. R., Leitao, A. D. G., Manor, U., & Encalada, S. E. (2021) · Science Advances · doi:10.1126/sciadv.abg3693 · Cited by 14

Identification of Alzheimer’s Disease Molecular Subtypes Based on Parallel Large-Scale Sequencing

Ma, M., Liao, Y., Huang, X., Zou, C., Chen, L., Liang, L., Meng, Y., Wu, Y., & Zou, D. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.770136 · Cited by 14

Evaluation of the Antioxidant and Neuroprotectant Activities of New Asymmetrical 1,3-Diketones

Nieto, C. I., Cornago, P., Cabildo, M. P., Sanz, D., Claramunt, R. M., Torralba, M. C., Torres, M. R., Martínez‐Casanova, D., Sánchez-Alegre, Y., Escudero, E., et al. (2018) · Molecules · doi:10.3390/molecules23081837 · Cited by 15

Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep

Liu, Z., Zhang, N., Wen, Z., Wang, H., Li, T., Ma, R., Li, M.-H., Wang, D., Shu, H., Huang, X., et al. (2025) · Advanced Science · doi:10.1002/advs.202506492 · Cited by 13

Circadian Rhythm Dysfunction in Neurodegenerative Diseases: A Bidirectional Perspective and Therapeutic Potential

Namgyal, D., & Lim, C. (2025) · Nature and Science of Sleep · doi:10.2147/nss.s561326 · Cited by 16

Explainable variational autoencoder (E-VAE) model using genome-wide SNPs to predict dementia

Vivek, S., Faul, J. D., Thyagarajan, B., & Guan, W. (2023) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2023.104536 · Cited by 15

Shared (epi)genomic background connecting neurodegenerative diseases and type 2 diabetes

Caputo, V., Termine, A., Strafella, C., Giardina, E., & Cascella, R. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i5.155 · Cited by 17

Structural Brain Imaging Phenotypes of Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) Found by Hierarchical Clustering

Kärkkäinen, M., Prakash, M., Zare, M., Tohka, J., & Initiative, A. D. N. (2020) · International Journal of Alzheimer s Disease · doi:10.1155/2020/2142854 · Cited by 15

Electroencephalographic hallmarks of Alzheimer’s disease

Ferreri, F., Miraglia, F., Vecchio, F., Manzo, N., Cotelli, M., Judica, E., & Rossini, P. M. (2022) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2022.08.005 · Cited by 14

Measuring Phospholipase D Enzymatic Activity Through Biochemical and Imaging Methods

Philip, F., Ha, E. E., Seeliger, M. A., & Frohman, M. A. (2016) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2016.09.041 · Cited by 14

Alzheimer’s disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics

Kurakin, A. V., & Bredesen, D. E. (2020) · Aging · doi:10.18632/aging.103883 · Cited by 15

Temporal model for central sensitization: A hypothesis for mechanism and treatment using systemic manual therapy, a focused review

Halili, A. (2022) · MethodsX · doi:10.1016/j.mex.2022.101942 · Cited by 16

Population Levels Assessment of the Distribution of Disease-Associated Variants With Emphasis on Armenians – A Machine Learning Approach

Nikogհosyan, M., Hakobyan, S., Hovhannisyan, A., Loeffler‐Wirth, H., Binder, H., & Arakelyan, A. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00394 · Cited by 12

EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease

Khavinson, V. K., Linkova, N. S., Kozhevnikova, E. O., & Trofimova, S. (2020) · Molecules · doi:10.3390/molecules26010159 · Cited by 13

Homeostasis of Lipid Metabolism in Disorders of the Brain

Johnson, J. L., & Johnson, L. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00146-8 · Cited by 13

The effect of lipid metabolism on age-associated cognitive decline: Lessons learned from model organisms and human

Wu, S., Liu, X., Yang, H., Ma, W., & Qin, Z. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.08.2194 · Cited by 13

Genetic factors related to the immune system in subjects at risk of developing Alzheimer's disease

Prendecki, M., Kowalska, M., Łagan-Jędrzejczyk, U., Piekut, T., Krokos, A., Kozubski, W. P., & Dorszewska, J. (2020) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2020.02.110 · Cited by 11

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer’s Disease

Kumar, M., & Bansal, N. (2021) · Current Drug Targets · doi:10.2174/1389450122666211118125233 · Cited by 14

Mitochondrial DNA oxidative mutations are elevated in Mexican American women potentially implicating Alzheimer’s disease

Reid, D. M., Barber, R. C., Thorpe, R. J., Sun, J., Zhou, Z., & Phillips, N. (2022) · npj Aging · doi:10.1038/s41514-022-00082-1 · Cited by 12

Analysis of Genetic Association Between ABCA7 Polymorphism and Alzheimer’s Disease Risk in the Southern Chinese Population

Wang, L., Jiao, Y., Zhao, A., Xu, X., Ye, G., Zhang, Y., Wang, Y., Deng, Y., Xu, W. L., & Liu, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.819499 · Cited by 12

A generic parallel framework for inferring large-scale gene regulatory networks from expression profiles: application to Alzheimer’s disease network

Sebastian, S., Roy, S., & Kalita, J. K. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac482 · Cited by 12

The p53/ZEB1-PLD3 feedback loop regulates cell proliferation in breast cancer

Liu, B., Sun, N., Lin, H. M., Zhou, X.-J., Ma, H., Wang, X., Cao, X., & Yu, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06271-4 · Cited by 12

Microbiome Engineering for Biotherapeutic in Alzheimer’s Disease Through the Gut–Brain Axis: Potentials and Limitations

Renesteen, E., Boyajian, J. L., Islam, P., Kassab, A., Abosalha, A. K., Makhlouf, S., Santos, M., Chen, H., Shum-Tim, C., & Prakash, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115351 · Cited by 11

Computational analysis of functional SNPs in Alzheimer’s disease-associated endocytosis genes

Tey, H. J., & Ng, C. H. (2019) · PeerJ · doi:10.7717/peerj.7667 · Cited by 11

Assessment of finger movement characteristics in dementia patients using a magnetic sensing finger-tap device

Sugioka, J., Suzumura, S., Kawahara, Y., Osawa, A., Maeda, N., Ito, M., Nagahama, T., Kuno, K., Shiramoto, K., Kizuka, S., et al. (2020) · Japanese Journal of Comprehensive Rehabilitation Science · doi:10.11336/jjcrs.11.91 · Cited by 11

Association of candidate genetic variants and circulating levels of ApoE/ApoJ with common neuroimaging features of cerebral amyloid angiopathy

Bonaterra‐Pastra, A., Benítez, S., Pancorbo, O., Rodríguez‐Luna, D., Vert, C., Rovira, À., Freijo, M. D. M., Tur, S., Martínez-Zabaleta, M., Portela, P. C., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1134399 · Cited by 11

Gene mutations in a Han Chinese Alzheimer's disease cohort

Ma, L., Zhang, J., Shi, Y., Wang, W., Ren, Z., Xia, M., Zhang, Y., & Yang, M. (2018) · Brain and Behavior · doi:10.1002/brb3.1180 · Cited by 11

Genetic Variants Associated With Alzheimer Disease in the 22 Arab Countries

Al-Thani, H. F., Ahmad, M. N., Younes, S. N., & Zayed, H. (2021) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000447 · Cited by 11

Tau immunotherapy in Alzheimer’s disease and progressive supranuclear palsy

Karimi, N., Catak, F. B., Arslan, E. O., Saghazadeh, A., & Rezaei, N. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109445 · Cited by 11

Bacopa monnieri protects neuronal cell line and Caenorhabditis elegans models of Alzheimer’s disease through sigma-1 receptor antagonist sensitive and antioxidant pathways

Brimson, J. M., Prasanth, M. I., Malar, D. S., Verma, K., Plaingam, W., & Tencomnao, T. (2022) · Nutrition and Healthy Aging · doi:10.3233/nha-220161 · Cited by 12

Investigation of Potential Drug Targets for Cholesterol Regulation to Treat Alzheimer’s Disease

Passero, M., Zhai, T., & Huang, Z. J. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20136217 · Cited by 10

Biomarkers and Risk Assessment of Alzheimer’s Disease in Low- and Middle-Income Countries

Adewale, B. A., Coker, M. M., Ogunniyi, A. O., Kalaria, R. N., & Akinyemi, R. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221030 · Cited by 11

Deconvolution reveals cell-type-specific transcriptomic changes in the aging mouse brain

Ren, Y., Wang, X., Zhang, S., Hu, H., Quicksall, Z., Lee, S., Morganti, J. M., Johnson, L. A., Asmann, Y. W., & Zhao, N. (2023) · Scientific Reports · doi:10.1038/s41598-023-44183-7 · Cited by 12

Re-Arranging the Puzzle between the Amyloid-Beta and Tau Pathology: An APP-Centric Approach

Haut, F., Argyrousi, E. K., & Arancio, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010259 · Cited by 11

Genetic Editing and Pharmacogenetics in Current And Future Therapy Of Neurocognitive Disorders

Prendecki, M., Kowalska, M., Totoń, E., & Kozubski, W. P. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666200422152440 · Cited by 10

Population Differentiation at the PVT1 Gene Locus: Implications for Prostate Cancer

Pal, G., Di, L., Orunmuyi, A. T., Olapade-Olaopa, E. O., Qiu, W., & Ogunwobi, O. O. (2020) · G3 Genes Genomes Genetics · doi:10.1534/g3.120.401291 · Cited by 10

Improving the Utility of Polygenic Risk Scores as a Biomarker for Alzheimer’s Disease

Vlachakis, D., Papakonstantinou, E., Sagar, R., Bacopoulou, F., Exarchos, T. P., Kourouthanassis, P. E., Karyotis, V. A., Vlamos, P., Lyketsos, C. G., Avramopoulos, D., et al. (2021) · Cells · doi:10.3390/cells10071627 · Cited by 10

Could immunotherapy and regulatory T cells be used therapeutically to slow the progression of Alzheimer’s disease?

Abbott, V., Housden, B. E., & Houldsworth, A. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf092 · Cited by 9

Advances in Gold Nanoparticles for the Diagnosis and Management of Alzheimer’s Disease

Sivamaruthi, B. S., Kesika, P., Sisubalan, N., & Chaiyasut, C. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17091158 · Cited by 9

The Other Side of Alzheimer’s Disease: Influence of Metabolic Disorder Features for Novel Diagnostic Biomarkers

Argentati, C., Tortorella, I., Bazzucchi, M., Emiliani, C., Morena, F., & Martino, S. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030115 · Cited by 10

Is pseudoexfoliation glaucoma a neurodegenerative disorder?

Padhy, B., & Alone, D. P. (2021) · Journal of Biosciences · doi:10.1007/s12038-021-00217-8 · Cited by 9

Sex Differences in Innate Immune Response of Peripheral Blood Leukocytes of Alzheimer’s Disease Patients

Sochocka, M., Ochnik, M., Sobczyński, M., Orzechowska, B., & Leszek, J. (2022) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-022-00653-w · Cited by 9

Fetal alcohol exposure impairs learning and memory functions and elevates levels of various biochemical markers of Alzheimer's disease in the brain of 12‐month‐old rats

Chaudhary, S., & Sarkar, D. K. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15061 · Cited by 11

Alzheimer's disease–associated PLCG2 variants alter microglial state and function in human induced pluripotent stem cell–derived microglia‐like cells

Bedford, L. M., Tutrow, K. D., Hooper, K., Messenger, E. J., Hernandez, M., Lamb, B. T., Meyer, J. S., Richardson, T. I., & Bissel, S. J. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70772 · Cited by 8

Nicotinic receptor components of amyloid beta 42 proteome regulation in human neural cells

Sinclair, P., & Kabbani, N. (2022) · PLoS ONE · doi:10.1371/journal.pone.0270479 · Cited by 8

Alzheimer's Disease and Other Neurodegenerative Diseases

Fuller, S. J., Sohrabi, H. R., Goozee, K. G., Sankaranarayanan, A., & Martins, R. N. (2019) · Wiley eBooks · doi:10.1002/9781119356752.ch2 · Cited by 8

Proteomic profiling in cerebrospinal fluid reveal biomarkers for shunt outcome in idiopathic normal-pressure hydrocephalus

Ying, Y., Lin, J., Gao, W., Yue, L., Zeng, Q., Bartas, K., Cheong, D., Jiang, H., Zheng, Z., Shi, L., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.04.043 · Cited by 9

Environmental carcinogens disproportionally mutate genes implicated in neurodevelopmental disorders

Baker, B. H., Zhang, S.-Y., Simon, J. M., McLarnan, S. M., Chung, W., & Pearson, B. L. (2021) · bioRxiv · doi:10.3389/fnins.2023.1106573 · Cited by 3

Distinctive subgingival microbial signatures in older adults with different levels of cognitive function

Chen, L., Li, X., Liu, J., Hou, Z., Wei, Y., Chen, M., Wang, B., Cao, H., Qiu, R., Zhang, Y., et al. (2024) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13997 · Cited by 7

Τhe Greek Variant in APP Gene: The Phenotypic Spectrum of APP Mutations

Kalampokini, S., Georgouli, D., Patrikiou, E., Provatas, A., Valotassiou, V. J., Georgoulias, P., Spanaki, C., Hadjigeorgiou, G. M., & Xiromerisiou, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212355 · Cited by 7

Phytochemical based Modulation of Endoplasmic Reticulum Stress in Alzheimer's Disease

Dsouza, V. L., Shivakumar, A. B., Kulal, N., Gangadharan, G., Kumar, D., & Kabekkodu, S. P. (2022) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026622666220624155357 · Cited by 8

Promoter haplotypes of interleukin-10 gene linked to cortex plasticity in subjects with risk of Alzheimer's disease

Bai, F., Xie, C., Yuan, Y., Shi, Y., & Zhang, Z. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.11.019 · Cited by 7

A Study Investigating the Role of 2 Candidate SNPs in Bax and Bcl-2 Genes in Alzheimer's Disease.

Erdal, M. E., Yılmaz, Ş. G., Ay, M. E., Kara, H. G., Özge, A., & Taşdelen, B. (2020) · PubMed · Cited by 7

Genetic Protection Modifications: Moving Beyond the Binary Distinction Between Therapy and Enhancement for Human Genome Editing

Mikkelsen, R. B., Frederiksen, H. R. S., Gjerris, M., Holst, B., Hyttel, P., Luo, Y., Freude, K., & Sandøe, P. (2019) · The CRISPR Journal · doi:10.1089/crispr.2019.0024 · Cited by 7

Epigenetic events influencing the biological clock: Panacea for neurodegeneration

Laxmi, I. P. L., & Tamizhselvi, R. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38836 · Cited by 8

The genetic landscape of Alzheimer disease

Carmona, S., Hardy, J., & Guerreiro, R. J. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64076-5.00026-0 · Cited by 140

The Genetic Basis of Alzheimer’s Disease

Hooli, B. V., & Tanzi, R. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802173-6.00002-2 · Cited by 6

Genetics of Alzheimer’s Disease

Chouraki, V. A., & Seshadri, S. S. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800149-3.00005-6 · Cited by 220

The Genetics of Alzheimer’s Disease

Tanzi, R. E. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199934959.003.0060 · Cited by 19

The Genetics of Alzheimer Disease: Back to the Future

Bertram, L., Lill, C. M., & Tanzi, R. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.013 · Cited by 834