The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Nonmotor gastrointestinal disorders in older patients with Parkinson’s disease: is there hope?
Open accessAbstract
Abstract: Despite the fact that nonmotor symptoms (NMS) like gastrointestinal (GI) complaints are frequently reported in Parkinson’s disease (PD), no therapeutic guidelines are available. This study aimed to manage some lower GI-NMS in a group of patients with PD. A total of 40 patients (17 males, 23 females; mean age 76.05±2.09 years) were randomly selected for this study. Patients were confirmed to have PD (modified Hoehn–Yars scale: 2.075±0.4) who had undergone levodopa or dopamine agonist treatment. In the non-motor symptoms questionnaire (NMS-Quest), regarding GI complaints, the following were recorded: abdominal pain, bloating, and constipation of mild-to-moderate severity. Laboratory studies, abdominal ultrasound, and upper and lower digestive endoscopies were performed to rule out organic issues. All patients increased their water intake to 2 L/d and alimentary fiber to 20–25 g/d. Twenty patients received trimebutine 200 mg three times daily half an hour before meals. The other 20 patients received probiotics (60 mg per-tablet of two lactic bacteria: Lactobacillus acidophilus and Bifidobacterium infantis ), 2×/d, 1 hour after meals for 3 months along with the reassessment of GI complaints. Our results demonstrated that there were significant statistical differences in all assessed symptoms in the first group: 1.55±0.51 vs 0.6±0.5 ( P <0.0001) for abdominal pain; 1.6±0.5 vs 0.45±0.51 ( P <0.0001) for bloating; and 1.5±0.51 vs 0.85±0.67 ( P =0.0014) for constipation with incomplete defecation. The second group displayed statistical differences only for abdominal pain 1.45±0.51 vs 1.05±0.69 ( P =0.00432) and bloating 1.4±0.5 vs 0.3±0.47 ( P <0.0001). For constipation with incomplete defecation, there was a slight improvement. Thus, there was no significant statistical difference: 1.35±0.49 vs 1.15±0.49 ( P =0.2040). In conclusion, lower GI-NMS are frequently present, isolated or associated with other autonomic issues, even before the diagnosis of PD. Treatment with probiotics could improve abdominal pain and bloating as much as with trimebutine, but less for constipation with incomplete evacuation, where trimebutine showed better results. Keywords: PD, lower GI-NMS, probiotics, prokinetics, trimebutine
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“studies have shown that Lactobacillus acidophilus and Bifidobacterium infantis can improve abdominal pain and bloating in PD patients [40]”
From Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota (2021) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Non-motor symptoms of Parkinson's disease: diagnosis and management
Chaudhuri, K. R., Healy, D. G., & Schapira, A. H. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70373-8 · Cited by 2,807
Goetz, C. G., Poewe, W. H., Rascol, O., Sampaio, C., Stebbins, G. T., Counsell, C. E., Giladi, N., Holloway, R. G., Moore, C. G., Wenning, G. K., et al. (2004) · Movement Disorders · doi:10.1002/mds.20213 · Cited by 2,360
Gut microbiota are related to Parkinson's disease and clinical phenotype
Scheperjans, F., Aho, V., Pereira, P. A. B., Koskinen, K., Paulin, L., Pekkonen, E., Haapaniemi, E., Kaakkola, S., Eerola‐Rautio, J., Pohja, M., et al. (2015) · Movement Disorders · doi:10.1002/mds.26069 · Cited by 1,968
Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment
Chaudhuri, К. R., & Schapira, A. H. V. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70068-7 · Cited by 1,818
Barone, P., Antonini, A., Colosimo, C., Marconi, R., Morgante, L., Avarello, T. P., Bottacchi, E., Cannas, A., Ceravolo, G., Ceravolo, R., et al. (2009) · Movement Disorders · doi:10.1002/mds.22643 · Cited by 1,445
What contributes to quality of life in patients with Parkinson's disease?
Schrag, A. E. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.3.308 · Cited by 1,420
Frequency of Bowel Movements and the Future Risk of Parkinson’s Disease
Abbott, R. D., Petrovitch, H., White, L. R., Masaki, K. H., Tanner, C. M., Curb, J. D., Grandinetti, A., Blanchette, P. L., Popper, J. S., & Ross, G. W. (2001) · Neurology · doi:10.1212/wnl.57.3.456 · Cited by 839
Brain-Gut-Microbiota Axis in Parkinson’s Disease
Mulak, A. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i37.10609 · Cited by 583
Martínez‐Martín, P., Schapira, A. H. V., Stocchi, F., Sethi, K. D., Odin, P., Macphee, G. J. A., Brown, R. G., Naidu, Y., Clayton, L. M. S., Abe, K., et al. (2007) · Movement Disorders · doi:10.1002/mds.21586 · Cited by 556
Cersosimo, M. G., Raina, G. B., Pecci, C., Pellene, A., Calandra, C. R., Gutiérrez, C., Micheli, F. E., & Benarroch, E. E. (2013) · Journal of Neurology · doi:10.1007/s00415-012-6801-2 · Cited by 314
Domperidone: A Peripherally Acting Dopamine 2 -Receptor Antagonist
Barone, J. A. (1999) · Annals of Pharmacotherapy · doi:10.1345/aph.18003 · Cited by 260
Antonini, A., Barone, P., Marconi, R., Morgante, L., Zappulla, S., Pontieri, F. E., Ramat, S., Ceravolo, M. G., Meco, G., Cicarelli, G., et al. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6557-8 · Cited by 245
Nonmotor manifestations of Parkinson's disease
Simuni, T., & Sethi, K. D. (2009) · Annals of Neurology · doi:10.1002/ana.21472 · Cited by 242
The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism
Pressley, J. C., Louis, E. D., Tang, M. ‐., Cote, L. J., Cohen, P. D., Glied, S., & Mayeux, R. P. (2003) · Neurology · doi:10.1212/wnl.60.1.87 · Cited by 229
Symptoms of autonomic failure in Parkinson?s disease: prevalence and impact on daily life
Magerkurth, C., Schnitzer, R., & Braune, S. (2005) · Clinical Autonomic Research · doi:10.1007/s10286-005-0253-z · Cited by 215
(2011) · PubMed · Cited by 207
Neural control of the gastrointestinal tract: Implications for Parkinson disease
Cersosimo, M. G., & Benarroch, E. E. (2008) · Movement Disorders · doi:10.1002/mds.22051 · Cited by 188
Zangaglia, R., Martignoni, E., Glorioso, M., Ossola, M., Riboldazzi, G., Calandrella, D., Brunetti, G., & Pacchetti, C. (2007) · Movement Disorders · doi:10.1002/mds.21243 · Cited by 177
The nonmotor symptoms of Parkinson's disease—An overview
Lim, S., & Lang, A. E. (2010) · Movement Disorders · doi:10.1002/mds.22786 · Cited by 171
WANG, A., LIAO, X., XIONG, L., PENG, S., XIAO, Y., LIU, S., HU, P., & CHEN, M. (2008) · BMC Gastroenterology · doi:10.1186/1471-230x-8-43 · Cited by 143
Autonomic dysfunction in parkinsonian disorders: assessment and pathophysiology
Asahina, M., Vichayanrat, E., Low, D. A., Iodice, V., & Mathias, C. J. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303135 · Cited by 139
Meta‐analysis of the effects of prokinetic agents in patients with functional dyspepsia
Hiyama, T., Yoshihara, M., Matsuo, K., Kusunoki, H., Kamada, T., Ito, M., Tanaka, S., Nishi, N., Chayama, K., & Haruma, K. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04493.x · Cited by 109
Non-motor symptoms of Parkinson’s disease: the patient’s perspective
Breen, K. C., & Drutyte, G. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0928-2 · Cited by 74
Schmulson, M., & Chang, L. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04637.x · Cited by 70
Non-Motor Aspects of Parkinson's Disease
Borek, L. L., Amick, M. M., & Friedman, J. H. (2006) · CNS Spectrums · doi:10.1017/s1092852900013560 · Cited by 53
The impact and management of nonmotor symptoms of Parkinson's disease.
Lyons, K. E., & Pahwa, R. (2011) · PubMed · Cited by 51
What contributes to quality of life in patients with Parkinson's disease?
Ward, C. D. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.3.289a · Cited by 39
[Autonomic disorders in Parkinson's disease].
Gołąb-Janowska, M., Budzianowska, A., & Honczarenko, K. (2011) · PubMed · Cited by 15
Gastrointestinal Symptoms in Parkinson Disease: Clinical Aspects and Management
Salat-Foix, D., Andrews, C. N., Meddings, J. B., & Suchowersky, O. (2011) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100012099 · Cited by 13
Flagged first, then by citations
Cited by
Sorted by citations
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Esfehani, R. J., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 586
Facchin, S., Bertin, L., Bonazzi, E., Lorenzon, G., Barba, C. D., Barberio, B., Zingone, F., Maniero, D., Scarpa, M., Ruffolo, C., et al. (2024) · Life · doi:10.3390/life14050559 · Cited by 455
Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling
Hamamah, S., Aghazarian, A., Nazaryan, A., Hajnal, A. S., & Covașă, M. (2022) · Biomedicines · doi:10.3390/biomedicines10020436 · Cited by 327
Shandilya, S., Kumar, S., Jha, N. K., Kesari, K. K., & Ruokolainen, J. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.09.005 · Cited by 310
Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders
Cheng, L.-H., Liu, Y.-W., Wu, C.-C., Wang, S. Z., & Tsai, Y.-C. (2019) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2019.01.002 · Cited by 312
Metadata
- Authors
- Georgescu, D., Ancusa, O., Georgescu, L., Ionita, I., & Reisz, D.
- Affiliations
- Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
- Corresponding author
- Ancusa, Oana
- Venue
- Clinical Interventions in Aging
- Publisher
- Informa UK Limited
- Published
- 2016-11
- Volume
- Volume 11
- Pages
- 1601-1608
- ISSN
- 1176-9092 (ISSN-L)
- 1178-1998
- PMC
- PMC5113937
- OpenAlex
- W2550869378
- Cited by
- 138
- References
- 29
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 29 · 2023: 21 · 2022: 34 · 2021: 20 · 2020: 5 · 2019: 4 · 2018: 1 · 2017: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Interventions in Aging (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- Parkinson's disease, non-motor symptoms, gastrointestinal symptoms, constipation, abdominal pain, bloating, trimebutine, probiotics, Lactobacillus acidophilus, Bifidobacterium infantis, dietary fiber, older adults, levodopa, dopamine agonists, symptom management, quality of life, activities of daily living
- MeSH terms
- Age Factors, Aged, Bifidobacterium, Female, Gastrointestinal Agents, Gastrointestinal Diseases, Humans, Lactobacillus acidophilus, Male, Parkinson Disease, Trimebutine, Probiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
