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Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications

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Wondmkun, Yohannes Tsegyie·2020·Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
DOI 10.2147/dmso.s275898PMC PMC7553667
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Abstract

Obesity is a triggering factor for diabetes associated with insulin resistance. In individuals who are obese, higher amounts of non-esterified fatty acids, glycerol, hormones, and pro-inflammatory cytokines that could participate in the development of insulin resistance are released by adipose tissue. Besides, endoplasmic reticulum stress, adipose tissue hypoxia, oxidative stress, lipodystrophy, and genetic background have a role in insulin resistance. However, no effective drug therapy was developed for type 2 diabetes mellitus targeting these physiological factors. This is might be due to a lack of agreement on the comprehensive mechanism of insulin resistance. Therefore, this review assesses the cellular components of each physiologic and pathophysiologic factors that are involved in obesity associated insulin resistance, and may encourage further drug development in this field.

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Sorted by citations

Authors
Wondmkun, Y. T.
Affiliations
Addis Ababa University (ET)
Corresponding author
Wondmkun, Yohannes Tsegyie
Venue
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Publisher
Informa UK Limited
Published
2020-10
Volume
Volume 13
Pages
3611-3616
ISSN
1178-7007 (ISSN-L)
DOI
10.2147/dmso.s275898
PMC
PMC7553667
OpenAlex
W3092068238
Cited by
706
References
6
Citations by year
2026: 81 · 2025: 182 · 2024: 205 · 2023: 138 · 2022: 71 · 2021: 29
FWCI
8.68
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetes Metabolic Syndrome and Obesity (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
Addis Ababa University
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
obesity, insulin resistance, type 2 diabetes, adipose tissue, free fatty acids, inflammatory cytokines, endoplasmic reticulum stress, adipose tissue hypoxia, oxidative stress, lipodystrophy, genetic susceptibility, pathophysiology, drug development

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