Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium
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Abstract: The purpose of the study was to reveal the therapeutic effect of quercetin (QUE) nanoparticle complex on diabetic nephropathy (DN) by regulating the expression of intercellular adhesion molecular-1 (ICAM-1) on endothelium as compared to free QUE. QUE 10 mg/kg as a single abdominal subcutaneous injection daily for 8 weeks continuously in diabetic rats and 10 mg/kg QUE nanoparticle complex as a single abdominal subcutaneous injection every 5 days, continuously administered for 8 weeks to diabetic rats. Blood and left kidneys were collected; pathological change of kidney, renal function, oxidative stress level, blood glucose level, serum lipid, urine protein, and albumin/creatinine ratio were measured; and neutrophil adhesion, ICAM-1 expression, and CD11b + cells infiltration were observed. Both QUE and QUE nanoparticle complex preconditioning ameliorated the pathological damage of kidney and improved renal function, alleviated renal oxidative stress injury, restricted inflammatory cells infiltration, and downregulated the ICAM-1 expression as compared to DN group, while QUE nanoparticle complex significantly alleviated this effect. Keywords: nanoparticle complex, quercetin, DN, ICAM-1, CD11b + , endothelium Corrigendum for this paper has been published
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Quercetin alleviates oxidative stress in diabetic nephropathy.
“Flavonoid quercetin alleviates oxidative stress in diabetic nephropathy (Tong et al. 2017), natural alkaloid berberine can inhibit the progression of the disease [Wu et al. 2012), and naturally occurring cinnamaldehyde is able to suppress oxidative stress in kidney diseases (Zheng et al. 2011).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Tong et al. 2017
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- Authors
- Tong, F., Liu, S., Yan, B., Li, X., Ruan, S., & Yang, S.
- Affiliations
- Xiamen University (CN)
- Fujian University of Traditional Chinese Medicine (CN)
- Corresponding author
- Yang, Shuyu
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2017-10
- Volume
- Volume 12
- Pages
- 7799-7813
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC5661459
- OpenAlex
- W2766695829
- Cited by
- 92
- References
- 54
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 13 · 2023: 9 · 2022: 18 · 2021: 16 · 2020: 8 · 2019: 3 · 2018: 5 · 2016: 1
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Keywords
- quercetin, nanocomplexes, diabetic nephropathy, ICAM-1, endothelium, neutrophil adhesion, oxidative stress, renal inflammation, renal function
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Diabetic Nephropathies, Endothelium, Kidney, Male, Quercetin, Down-Regulation, Rats, Sprague-Dawley, Oxidative Stress, Intercellular Adhesion Molecule-1, CD11 Antigens, Nanoparticles
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