Cited by 92Chronic Kidney Disease and DiabetesNatural Antidiabetic Agents StudiesRenal Diseases and Glomerulopathies

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

Open access
Tong, Fei, Liu, Suhuan, Yan, Bing, Li, Xuejun, Ruan, Shiwei, Yang, Shuyu·2017·International Journal of Nanomedicine

Abstract

Abstract: The purpose of the study was to reveal the therapeutic effect of quercetin (QUE) nanoparticle complex on diabetic nephropathy (DN) by regulating the expression of intercellular adhesion molecular-1 (ICAM-1) on endothelium as compared to free QUE. QUE 10 mg/kg as a single abdominal subcutaneous injection daily for 8 weeks continuously in diabetic rats and 10 mg/kg QUE nanoparticle complex as a single abdominal subcutaneous injection every 5 days, continuously administered for 8 weeks to diabetic rats. Blood and left kidneys were collected; pathological change of kidney, renal function, oxidative stress level, blood glucose level, serum lipid, urine protein, and albumin/creatinine ratio were measured; and neutrophil adhesion, ICAM-1 expression, and CD11b + cells infiltration were observed. Both QUE and QUE nanoparticle complex preconditioning ameliorated the pathological damage of kidney and improved renal function, alleviated renal oxidative stress injury, restricted inflammatory cells infiltration, and downregulated the ICAM-1 expression as compared to DN group, while QUE nanoparticle complex significantly alleviated this effect. Keywords: nanoparticle complex, quercetin, DN, ICAM-1, CD11b + , endothelium Corrigendum for this paper has been published

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2147/ijn.s146978

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Quercetin alleviates oxidative stress in diabetic nephropathy.

    “Flavonoid quercetin alleviates oxidative stress in diabetic nephropathy (Tong et al. 2017), natural alkaloid berberine can inhibit the progression of the disease [Wu et al. 2012), and naturally occurring cinnamaldehyde is able to suppress oxidative stress in kidney diseases (Zheng et al. 2011).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Tong, F., Liu, S., Yan, B., Li, X., Ruan, S., & Yang, S.
Affiliations
  • Xiamen University (CN)
  • Fujian University of Traditional Chinese Medicine (CN)
Corresponding author
Yang, Shuyu
Venue
International Journal of Nanomedicine
Published
2017-10
Volume
Volume 12
Pages
7799-7813
ISSN
  • 1176-9114 (ISSN-L)
  • 1178-2013
OpenAlex
W2766695829
Cited by
92
References
54
Citations by year
2026: 12 · 2025: 7 · 2024: 13 · 2023: 9 · 2022: 18 · 2021: 16 · 2020: 8 · 2019: 3 · 2018: 5 · 2016: 1
FWCI
3.91
Type
journal article
Language
en
Open access
Locations
  • International Journal of Nanomedicine (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
Keywords
quercetin, nanocomplexes, diabetic nephropathy, ICAM-1, endothelium, neutrophil adhesion, oxidative stress, renal inflammation, renal function
MeSH terms
Animals, Diabetes Mellitus, Experimental, Diabetic Nephropathies, Endothelium, Kidney, Male, Quercetin, Down-Regulation, Rats, Sprague-Dawley, Oxidative Stress, Intercellular Adhesion Molecule-1, CD11 Antigens, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review