Application of Active Targeting Nanoparticle Delivery System for Chemotherapeutic Drugs and Traditional/herbal Medicines in Cancer Therapy: a Systematic Review
Open accessAbstract
Patients treated with conventional cancer chemotherapy suffer from side effects of the drugs due to non-selective action of chemotherapeutic drugs to normal cells. Active targeting nanoparticles that are conjugated to targeting ligands on the surface of nanoparticles play an important role in improving drug selectivity to the cancer cell. Several chemotherapeutic drugs and traditional/herbal medicines reported for anticancer activities have been investigated for their selective delivery to cancer cells by active targeting nanoparticles. This systematic review summarizes reports on this application. Literature search was conducted through PubMed database search up to March 2017 using the terms nanoparticle, chemotherapy, traditional medicine, herbal medicine, natural medicine, natural compound, cancer treatment, and active targeting. Out of 695 published articles, 61 articles were included in the analysis based on the predefined inclusion and exclusion criteria. The targeting ligands included proteins/peptides, hyaluronic acid, folic acid, antibodies/antibody fragments, aptamer, and carbohydrates/polysaccharides. In vitro and in vivo studies suggest that active targeting nanoparticles increase selectivity in cellular uptake and/or cytotoxicity over the conventional chemotherapeutic drugs and non-targeted nanoparticle platform, particularly enhancement of drug efficacy and safety. However, clinical studies are required to confirm these findings.
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Some previously published systematic reviews in cancer nano-medicine have focused on specific subsections, like using nanoparticles for actively-targeted delivery of chemotherapeutics or herbal medicine.
“Some previously published systematic reviews in cancer nano-medicine have focused on specific subsections, like using nanoparticles for actively-targeted delivery of chemotherapeutics or herbal medicine (Muhamad et al., 2018).”
From Sysrev: A FAIR Platform for Data Curation and Systematic Evidence Review (2021) · cites this paper as Muhamad et al., 2018
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- Authors
- Muhamad, N., Plengsuriyakarn, T., & Na-Bangchang, K.
- Affiliations
- Thammasat University (TH)
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2018-07
- Volume
- Volume 13
- Pages
- 3921-3935
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC6038858
- OpenAlex
- W2809924458
- Cited by
- 410
- References
- 73
- Citations by year
- 2026: 25 · 2025: 41 · 2024: 45 · 2023: 49 · 2022: 74 · 2021: 71 · 2020: 68 · 2019: 36 · 2018: 1
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Thammasat University
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- targeted drug delivery, chemotherapeutic drugs, traditional medicine, herbal medicine, natural compounds, anticancer activity, targeting ligands, hyaluronic acid, folic acid, aptamers, antibody fragments, tumor selectivity, chemotherapy side effects
- MeSH terms
- Antineoplastic Agents, Humans, Neoplasms, Drug Delivery Systems, Herbal Medicine, Nanoparticles
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