Effect of young exosomes injected in aged mice
Open accessAbstract
Introduction: Exosomes, nano-sized extracellular vesicles, are known to circulate through the blood stream to transfer molecular signals from tissue to tissue. Methods: To determine whether exosomes affect aging in animals, we primarily identified the changes in exosomal miRNA contents during the aging process. In exosomes from 12-month-old mice, mmu-miR-126-5p and mmu-miR-466c-5p levels were decreased and mmu-miR-184-3p and mmu-miR-200b-5p levels were increased significantly compared with those of 3-month-old mice. Their levels in exosomes were partially correlated with those in tissues: levels of only mmu-miR-126-5p and mmu-miR-466c-5p in lungs and/or liver were decreased, but those of mmu-miR-184-3p and mmu-miR-200b-5p in tissues did not coincide with those of exosomes. Results and discussion: In the aged tissues injected with young exosomes isolated from serum, mmu-miR-126b-5p levels were reversed in the lungs and liver. Expression changes in aging-associated molecules in young exosome-injected mice were obvious: p16 Ink4A , MTOR, and IGF1R were significantly downregulated in the lungs and/or liver of old mice. In addition, telomerase-related genes such as Men1 , Mre11a , Tep1 , Terf2 , Tert , and Tnks were significantly upregulated in the liver of old mice after injection of young exosomes. Conclusion: These results indicate that exosomes from young mice could reverse the expression pattern of aging-associated molecules in aged mice. Eventually, exosomes may be used as a novel approach for the treatment and diagnosis of aging animals. Keywords: exosome, injection, reverse aging, telomerase, biomarker, molecular therapy
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Injection of 3-month-old mice blood EVs to 18-month-old mice reverses the expression of aging-associated biomarkers.
“the injection of 3-month-old mice blood EVs to 18-month-old mice reversed the expression aging-associated biomarkers”
From Skeletal Muscle-Released Extracellular Vesicles: State of the Art (2019) · cites this paper as Lee et al., 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 1× · see citing works
“1,2 It has been reported that the upregulated or downregulated miRNAs induce cellular senescence.”
mTOR is a key modulator of ageing and age-related disease
Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676 · see citing works
Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., & Wrana, J. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.024 · Cited by 1,311 · see citing works
Kaushik, S., & Cuervo, A. M. (2015) · Nature Medicine · doi:10.1038/nm.4001 · Cited by 899 · see citing works
Simonsen, J. L., Rosada, C., Serakıncı, N., Justesen, J., Stenderup, K., Rattan, S. I. S., Jensen, T. G., & Kassem, M. S. (2002) · Nature Biotechnology · doi:10.1038/nbt0602-592 · Cited by 806 · see citing works
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
Chiang, H. R., Schoenfeld, L. W., Ruby, J. G., Auyeung, V. C., Spies, N., Baek, D., Johnston, W. K., Russ, C., Luo, S., Babiarz, J. E., et al. (2010) · Genes & Development · doi:10.1101/gad.1884710 · Cited by 732 · see citing works
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
Zhang, Y., Kim, M. S., Jia, B., Yan, J., Zuniga-Hertz, J. P., Han, C., & Cai, D. (2017) · Nature · doi:10.1038/nature23282 · Cited by 564 · see citing works
Bernardes de Jesus, B., Vera, E., Schneeberger, K., Tejera, A. M., Ayuso, E., Bosch, F., & Blasco, M. A. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200245 · Cited by 548 · see citing works
MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers
Seike, M., Goto, A., Okano, T., Bowman, E. D., Schetter, A. J., Horikawa, I., Mathe, E. A., Jen, J., Yang, P., Sugimura, H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905234106 · Cited by 500 · see citing works
Lugli, G., Cohen, A. M., Bennett, D. A., Shah, R. C., Fields, C. J., Hernandez, A. G., & Smalheiser, N. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139233 · Cited by 423 · see citing works
Adhesion and signaling by B cell‐derived exosomes: the role of integrins
Clayton, A., Turkes, A., Dewitt, S., Steadman, R., Mason, M. D., & Hallett, M. B. (2004) · The FASEB Journal · doi:10.1096/fj.03-1094fje · Cited by 339 · see citing works
Age-related changes in microRNA levels in serum
Hooten, N. N., Fitzpatrick, M., Wood, W. H., De, S., Ejiogu, N., Zhang, Y., Mattison, J. A., Becker, K. G., Zonderman, A. B., & Evans, M. K. (2013) · Aging · doi:10.18632/aging.100603 · Cited by 329 · see citing works
The Roles of Tumor-Derived Exosomes in Cancer Pathogenesis
Yang, C., & Robbins, P. D. (2011) · Clinical and Developmental Immunology · doi:10.1155/2011/842849 · Cited by 318 · see citing works
p16INK4a Translation Suppressed by miR-24
Lal, A., Kim, H. H., Abdelmohsen, K., Kuwano, Y., Pullmann, R., Srikantan, S., Subrahmanyam, R., Martindale, J. L., Yang, X., Ahmed, F., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001864 · Cited by 268 · see citing works
Kolhe, R. B., Hunter, M., Liu, S. M., Jadeja, R. N., Pundkar, C. Y., Mondal, A. K., Mendhe, B., Drewry, M. D., Rojiani, M. V., Liu, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01905-y · Cited by 227 · see citing works
Liu, C., Song, J., Zhang, Y., & Wang, P. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2484 · Cited by 221 · see citing works
Circulatory miR-34a as an RNA-based, noninvasive biomarker for brain aging
Li, X., Khanna, A., Li, N., & Wang, E. (2011) · Aging · doi:10.18632/aging.100371 · Cited by 183 · see citing works
Circulating inflamma-miRs in aging and age-related diseases
Olivieri, F., Rippo, M. R., Procopio, A. D., & Fazioli, F. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00121 · Cited by 179 · see citing works
MicroRNAs in Salivary Exosome as Potential Biomarkers of Aging
Machida, T., Tomofuji, T., Ekuni, D., Maruyama, T., Yoneda, T., Kawabata, Y., Mizuno, H., Miyai, H., Kunitomo, M., & Morita, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160921294 · Cited by 144 · see citing works
Extracellular Vesicles as New Players in Cellular Senescence
Urbanelli, L., Buratta, S., Sagini, K., Tancini, B., & Emiliani, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091408 · Cited by 121 · see citing works
Anti-oncogenic MicroRNA-203 Induces Senescence by Targeting E2F3 Protein in Human Melanoma Cells
Noguchi, S., Mori, T., Otsuka, Y., Yamada, N. O., Yasui, Y., Iwasaki, J., Kumazaki, M., Maruo, K., & Akao, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.325027 · Cited by 114 · see citing works
Telomerase and the aging process
Hornsby, P. J. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.007 · Cited by 112 · see citing works
Castellano, L., & Stebbing, J. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1474 · Cited by 107 · see citing works
Exosomes-Based Gene Therapy for MicroRNA Delivery
Mathiyalagan, P., & Sahoo, S. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6588-5_9 · Cited by 99 · see citing works
Exosome-based small RNA delivery: Progress and prospects
Lu, M., Xing, H., Xun, Z., Yang, T., Ding, P., Cai, C., Wang, D., & Zhao, X. (2018) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2017.07.008 · Cited by 97 · see citing works
Cellular senescence mediated by p16INK4A-coupled miRNA pathways
Overhoff, M. G., Garbe, J. C., Koh, J., Stampfer, M. R., Beach, D. H., & Bishop, C. L. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1096 · Cited by 77 · see citing works
A Disease or Not a Disease? Aging As a Pathology
Gladyshev, T. V., & Gladyshev, V. N. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.09.009 · Cited by 71 · see citing works
Capturing time-resolved changes in molecular structure by negative staining
Zhao, F.-Q., & Craig, R. W. (2003) · Journal of Structural Biology · doi:10.1016/s1047-8477(02)00546-4 · Cited by 69 · see citing works
Boucher, J., Charalambous, M., Zarse, K., Mori, M. A., Kleinridders, A., Ristow, M., Ferguson‐Smith, A. C., & Kahn, C. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415475111 · Cited by 58 · see citing works
A Systematic Approach to Defining the microRNA Landscape in Metastasis
Mudduluru, G., Abba, M. L., Batliner, J., Patil, N., Scharp, M., Lunavat, T. R., Leupold, J. H., Oleksiuk, O., Juraeva, D., Thiele, W., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0997 · Cited by 58 · see citing works
Circulating markers of ageing and allostatic load: A slow train coming
Shiels, P., Stenvinkel, P., Kooman, J., & McGuinness, D. (2016) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2016.04.002 · Cited by 55 · see citing works
Li, M., Chiu, J., Gagne, J., & Fukagawa, N. K. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21507 · Cited by 54 · see citing works
Owczarz, M., Budzińska, M., Domaszewska-Szostek, A., Borkowska, J., Połosak, J., Gewartowska, M., Ślusarczyk, P., & Puzianowska‐Kuźnicka, M. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217720884 · Cited by 54 · see citing works
Cardiac Injury after 10 Gy Total Body Irradiation: Indirect Role of Effects on Abdominal Organs
Lenarczyk, M., Lam, V., Jensen, E. S., Fish, B. L., Su, J., Koprowski, S. L., KOMOROWSKI, R. A., Harmann, L. M., Migrino, R. Q., Li, X. A., et al. (2013) · Radiation Research · doi:10.1667/rr3292.1 · Cited by 48 · see citing works
Lai, C., Wu, Y., Yu, S., Yu, Y., Lee, S., Liu, C., Hsieh, W., Hwu, H., Chen, P., Jeng, S., et al. (2014) · Aging Cell · doi:10.1111/acel.12225 · Cited by 38 · cited 1× · see citing works
“11,12 One of the ways by which miRNAs are released in circulation is via vesicles blebbed out from cellular membranes.”
Lewkowicz, P., Ćwiklińska, H., Mycko, M. P., Cichalewska, M., Domowicz, M., Lewkowicz, N., Jurewicz, A., & Selmaj, K. W. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4794-14.2015 · Cited by 37 · see citing works
Ros, X. B., Gironella, M., & Fillat, C. (2014) · Molecular Therapy · doi:10.1038/mt.2014.98 · Cited by 36 · see citing works
Reverse Expression of Aging-Associated Molecules through Transfection of miRNAs to Aged Mice
Kim, J., Lee, B., Choi, E., Lee, K., Choi, S., Cho, J. H., Jeon, W. B., & Kim, E. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2016.11.005 · Cited by 34 · see citing works
Self-citationReduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice
Essers, P., Tain, L. S., Nespital, T., Gonçalves, J., Fröhlich, J., & Partridge, L. (2016) · Scientific Reports · doi:10.1038/srep30290 · Cited by 28 · see citing works
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
Zhang, Y., Kim, M. S., Jia, B., Yan, J., Zuniga-Hertz, J. P., Chen, H., & Cai, D. (2018) · Yearbook of pediatric endocrinology · doi:10.1530/ey.15.1.3 · Cited by 21 · see citing works
Aging increases p16INK4a expression in vascular smooth-muscle cells
Rodriguez-Menocal, L., Pham, S. M., Mateu, D., St-Pierre, M., Wei, Y., Pestana, I. A., Aı̈touche, A., & Vázquez-Padrón, R. I. (2009) · Bioscience Reports · doi:10.1042/bsr20080128 · Cited by 20 · see citing works
Flagged first, then by citations
1 of the 43 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Ha, D. H., Kim, H.-K., Lee, J., Kwon, H. H., Park, G., Yang, S. H., Jung, J. Y., Choi, H., Lee, J. H., Sung, S., et al. (2020) · Cells · doi:10.3390/cells9051157 · Cited by 545 · see citing works
Aging Hallmarks and the Role of Oxidative Stress
Maldonado, E., Morales-Pison, S., Urbina, F., & Solari, A. (2023) · Antioxidants · doi:10.3390/antiox12030651 · Cited by 421 · see citing works
Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy
Vakhshiteh, F., Atyabi, F., & Ostad, S. N. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s200036 · Cited by 283 · see citing works
Roles of extracellular vesicles in the aging microenvironment and age‐related diseases
Yin, Y., Chen, H., Wang, Y., Zhang, L., & Wang, X. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12154 · Cited by 199 · see citing works
The role of extracellular vesicles in skeletal muscle and systematic adaptation to exercise
Vechetti, I. J., Valentino, T., Mobley, C. B., & McCarthy, J. J. (2021) · The Journal of Physiology · doi:10.1113/jp278929 · Cited by 141 · see citing works
Skeletal Muscle-Released Extracellular Vesicles: State of the Art
Rome, S., Forterre, A., Mizgier, M. L., & Bouzakri, K. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00929 · Cited by 139 · see citing works
Hou, J., Chen, K., He, C., Li, X., Huang, M., Jiang, Y.-Z., Jiao, Y.-R., Xiao, Q., He, W., Liu, L., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00694-0 · Cited by 136 · see citing works
Sanz-Ros, J., Romero-García, N., Mas-Bargues, C., Monleón, D., Gordevicius, J., Brooke, R. T., Dromant, M., Díaz, A., Derevyanko, A., Guío-Carrión, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq2226 · Cited by 131 · see citing works
Brain Derived Exosomes Are a Double-Edged Sword in Alzheimer’s Disease
Song, Z., Xu, Y., Deng, W., Zhang, L., Zhu, H., Yü, P., Qu, Y., Zhao, W., Han, Y., & Qin, C. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00079 · Cited by 103 · see citing works
Wang, K., Ru, J., Zhang, H., Chen, J., Lin, X., Lin, Z., Wen, M., Huang, L., Ni, H., Zhuge, Q., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00848 · Cited by 87 · see citing works
Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer’s disease
Watson, L. S., Hamlett, E. D., Stone, T. D., & Sims‐Robinson, C. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0317-5 · Cited by 72 · see citing works
Stem Cell-Derived Exosomes: A New Method for Reversing Skin Aging
Wu, J., Wu, S., Zhang, L.-P., Zhao, X., Li, Y., Yang, Q.-Y., Yuan, R., Liu, J.-L., Mao, H., & Zhu, N. (2022) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-022-00461-5 · Cited by 60 · see citing works
Shaban, S. A., Rezaie, J., & Nejati, V. (2022) · Cardiovascular Toxicology · doi:10.1007/s12012-022-09740-y · Cited by 51 · see citing works
Adipocyte-Derived Extracellular Vesicles: State of the Art
Rome, S., Blandin, A., & Lay, S. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041788 · Cited by 51 · see citing works
Exosomes as Actively Targeted Nanocarriers for Cancer Therapy
Wang, Y., Zhang, Y., Cai, G., & Li, Q. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s239548 · Cited by 50 · see citing works
Loch-Neckel, G., Matos, A. T., Vaz, A. R., & Brites, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.839790 · Cited by 46 · see citing works
Thome, A. D., Thonhoff, J. R., Zhao, W., Faridar, A., Wang, J., Beers, D. R., & Appel, S. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.875825 · Cited by 40 · see citing works
Lay, S. L., Rome, S., Loyer, X., & Nieto, L. (2021) · FASEB BioAdvances · doi:10.1096/fba.2020-00147 · Cited by 38 · see citing works
Ronan, G., Bahçecioğlu, G., Yang, J., & Zorlutuna, P. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2024.122671 · Cited by 36 · see citing works
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109771 · Cited by 36 · see citing works
Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases
Sanz‐Ros, J., Mas‐Bargues, C., Romero-García, N., Huete-Acevedo, J., Dromant, M., & Borrás, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314632 · Cited by 34 · see citing works
Harnessing exosomes for targeted drug delivery systems to combat brain cancer
Basyoni, A. E., Atta, A., Salem, M. M., & Mohamed, T. M. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03731-z · Cited by 34 · see citing works
Zhou, J. F., Ding, Y., Zhang, Y., Zheng, D., Yan, L.-F., Guo, M., Mao, Y., & Yang, L. (2022) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-022-05956-4 · Cited by 32 · see citing works
MicroRNA-126: From biology to therapeutics
Guo, B., Gu, J., Zhuang, T., Zhang, J., Fan, C., Li, Y., Zhao, M., Chen, R., Wang, R., Kong, Y., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117953 · Cited by 33 · see citing works
Friends and foes: Extracellular vesicles in aging and rejuvenation
Lananna, B. V., & Imai, S. (2021) · FASEB BioAdvances · doi:10.1096/fba.2021-00077 · Cited by 30 · see citing works
Zhang, H., & Jin, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061908 · Cited by 21 · see citing works
miRNA expression profiling uncovers a role of miR‐302b‐3p in regulating skin fibroblasts senescence
Tan, J., Hu, L., Yang, X., Zhang, X., Wei, C., Lü, Q., Chen, Z., & Li, J. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28862 · Cited by 25 · see citing works
Sourki, P. A., Pourfathollah, A. A., Kaviani, S., Zomorrod, M. S., Ajami, M., Wollenberg, B., Multhoff, G., & Dezfouli, A. B. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112142 · Cited by 24 · see citing works
The Double-Edged Role of Extracellular Vesicles in the Hallmarks of Aging
Romero-García, N., Huete-Acevedo, J., Mas‐Bargues, C., Sanz‐Ros, J., Dromant, M., & Borrás, C. (2023) · Biomolecules · doi:10.3390/biom13010165 · Cited by 25 · see citing works
Liu, F., Liu, S., Luo, X., Fan, Z., Huang, S., Deng, F., Liu, H., & Shi, G. (2023) · Experimental Dermatology · doi:10.1111/exd.14948 · Cited by 21 · see citing works
Liu, Y., Mu, H., Chen, Y., Li, K., Mei, Q., Wang, L., Tang, T., Shen, Q., Li, H., Zhang, L., et al. (2024) · Life Medicine · doi:10.1093/lifemedi/lnae013 · Cited by 21 · see citing works
EXOSOME RELEASE AND CARGO IN DOWN SYNDROME
Hamlett, E., Larosa, A. C., Mufson, E., Fortea, J., Ledreux, A., & Granholm, A. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22712 · Cited by 21 · see citing works
Long-term chronic caloric restriction alters miRNA profiles in the brain of ageing mice
Özorhan, Ü., Tuna, B. G., Cicekdal, M. B., Kuşkucu, A., Bayrak, Ö. F., Yilmaz, B., Demirel, P. B., Cleary, M. P., & Dogan, S. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521001239 · Cited by 20 · see citing works
Extracellular Vesicles and Hematopoietic Stem Cell Aging
Goldberg, L. R. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314643 · Cited by 20 · see citing works
Intercellular communication is crucial in the regulation of healthy aging via exosomes
Sun, H., Xia, T., Ma, S., Lv, T., & Li, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107591 · Cited by 23 · see citing works
Noori, L., Filip, K., Nazmara, Z., Mahakizadeh, S., Hassanzadeh, G., Bavisotto, C. C., Bucchieri, F., Marino, A., Cappello, F., Wnuk, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020927 · Cited by 18 · see citing works
Depciuch, J., Klębowski, B., Stec, M., Szatanek, R., Węglarczyk, K., Baj‐Krzyworzeka, M., Parlińska‐Wojtan, M., & Baran, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051826 · Cited by 17 · see citing works
Exosomes in aging and age-related disorders: mechanisms, therapeutic potentials, and challenges
Safaei, S., Sohrabi, S., Zahmatkesh, P., Soltani‐Zangbar, M. S., & Maleki, L. A. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07379-1 · Cited by 17 · see citing works
Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles
Zheng, B., Wang, X., Guo, M., & Tzeng, C. (2025) · Cell Transplantation · doi:10.1177/09636897241297623 · Cited by 15 · see citing works
Synergistic Anti-Ageing through Senescent Cells Specific Reprogramming
Chen, R., & Skutella, T. (2022) · Cells · doi:10.3390/cells11050830 · Cited by 15 · see citing works
Barbosa, M., Santos, M., de Sousa, N., Duarte-Silva, S., Vaz, A. R., Salgado, A. J., & Brites, D. (2022) · Biomedicines · doi:10.3390/biomedicines10092120 · Cited by 14 · see citing works
Jin, Y., Sun, G., Chen, B., Feng, S., Tang, M., Wang, H., Zhang, Y., Wang, Y., An, Y., Xiao, Y., et al. (2025) · BMC Biology · doi:10.1186/s12915-025-02143-9 · Cited by 14 · see citing works
Small extracellular vesicles associated miRNA in myocardial fibrosis
Long, M., & Cheng, M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150336 · Cited by 9 · see citing works
Intercellular communication and aging
Ribeiro‐Rodrigues, T., Kelly, G., Korolchuk, V. I., & Girão, H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00005-7 · Cited by 9 · see citing works
Extracellular vesicle‐encapsulated miR ‐30c‐5p reduces aging‐related liver fibrosis
Rodrigues, A. C., Heng, Y. J., & Slack, F. J. (2024) · Aging Cell · doi:10.1111/acel.14310 · Cited by 10 · see citing works
Extracellular vesicles: the key to unlocking mechanisms of age-related vascular disease?
Whitehead, M., Antonazzi, M., & Shanahan, C. M. (2024) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.49 · Cited by 7 · see citing works
PRP, Exosomes, and Stem Cells: An International Perspective
Singh, N., Brown, A. N., & Gold, M. H. (2024) · Dermatological Reviews · doi:10.1002/der2.70000 · Cited by 7 · see citing works
Livkisa, D., Lee, T.-L., Yeh, W.-T., Jaimes, M. A., Szomolay, B., Liao, C., & Lundy, D. J. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00472-x · Cited by 8 · see citing works
Extracellular Vesicles and Cellular Ageing
Romero-García, N., Mas‐Bargues, C., Huete-Acevedo, J., & Borrás, C. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-21410-3_11 · Cited by 4 · see citing works
Maria, M. K. M., Moniem, E. M. A., Hanafy, A. K., Farag, D. B. E., Radwan, I. A., Abbass, M. M. S., Moshy, S. E., Rady, D., Dörfer, C. E., & El‐Sayed, K. M. F. (2025) · Dentistry Journal · doi:10.3390/dj13030106 · Cited by 4 · see citing works
Cechinel, L. R., Batabyal, R., Corssac, G. B., Goldberg, M., Harmon, B. T., Carregal, V. M., Bruch, G. E., Massensini, A. R., Belló‐Klein, A., Araújo, A. S. D. R., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11112920 · Cited by 4 · see citing works
EXOSOMES FROM CYCLIC MICE MODULATE LIVER TRANSCRIPTOME IN ESTROUPAUSE MICE INDEPENDENT OF AGE
Zanini, B. M., Ávila, B. M., Hense, J. D., Garcia, D. N., Ashiqueali, S., Alves, P. I. C., Oliveira, T. L., Collares, T. V., Brieño‐Enríquez, M. A., Mason, J. B., et al. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112508 · Cited by 3 · see citing works
Farrokhi, V., Afrisham, R., Soleimani, M., Ahmadvand, M., Mousavi, S. H., Kashanikhatib, Z., Owchi, S., Mohammadali, F., & Alizadeh, S. (2024) · The Natural Products Journal · doi:10.2174/0122103155285692240301052306 · Cited by 3 · see citing works
Moradi, R., Afrisham, R., Kashanikhatib, Z., Mousavi, S. H., Soleimani, M., & Alizadeh, S. (2024) · Indian Journal of Hematology and Blood Transfusion · doi:10.1007/s12288-024-01779-x · Cited by 3 · see citing works
Baba, B., Ceylani, T., Teker, H. T., Keskin, S., Genç, A. İ., Gurbanov, R., & Açıkgöz, E. (2025) · Biogerontology · doi:10.1007/s10522-025-10260-9 · Cited by 3 · see citing works
Park, Y., Kim, S., Yang, J., & Hyun, H. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202502680 · Cited by 2 · see citing works
Potential Roles of Exosomes in Aging and Age-Related Diseases
Hosseini, L., & Abolhasanpour, N. (2023) · International Journal of Aging · doi:10.34172/ija.2023.e22 · Cited by 2 · see citing works
Exosomes: a novel vesicular drug delivery platform
Aboulaghras, S., Omari, N. E., Balahbib, A., & Bouyahya, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91864-0.00002-4 · Cited by 1 · see citing works
Cell-to-Cell Communication in Aging: Mechanisms, Impact and Therapeutic Prospects
Mas‐Bargues, C., Sanz‐Ros, J., Huete-Acevedo, J., & Borrás, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-55022-5_8 · Cited by 1 · see citing works
Extracellular vesicles at the neuromuscular junction: messengers of synaptic health and disease
Qaisar, R. (2026) · Cell and Tissue Research · doi:10.1007/s00441-026-04050-z · Cited by 1 · see citing works
Elliot, S. J., Grimaldo, S., Catanuto, P., Pereira‐Simon, S., Xia, X., Civettini, G., Shahzeidi, S., Pastar, I., Tomic‐Canic, M., & Glassberg, M. K. (2026) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2026.102927 · Cited by 2 · see citing works
Young cardiac telocyte-derived exosomes rejuvenate aging hearts in rats
Lv, L., Zhu, Y., Chen, Y., Zheng, X., Huang, R., Zhao, H., Yuan, Z., Feng, S., Qi, X., Chen, Y., et al. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1824533 · Cited by 1 · see citing works
Sanz‐Ros, J., Mas‐Bargues, C., Monleón, D., Gordevičius, J., Brooke, R. T., Dromant, M., Derevyanko, A., Guío-Carrión, A., Román-Domínguez, A., Romero-García, N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.29.454302
Alzheimer disease and neuroinflammation in Down syndrome
Ganguly, B. B. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90456-8.00014-4
Exosomes: a novel tool for diagnosis and therapy
Bouyahya, A., Bakrim, S., Yaagoubi, O. M. E., Hakkour, M., Balahbib, A., Menyiy, N. E., Chamkhi, I., & Omari, N. E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89953-6.00001-5
Gewebe vermitteln mit genetischen Informationen ihren Funktionszustand
Laube, W. (2023) · Springer eBooks · doi:10.1007/978-3-662-67753-7_10
Monteleone, M. C., Billi, S. C., Abarzúa-Catalán, L., Henzi, R., Fernández, E. M., Kaehne, T., Wyneken, Ú., & Brocco, M. A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0308976
EXOSOMES FROM CYCLIC MICE MODULATE LIVER TRANSCRIPTOME IN ESTROUPAUSE MICE INDEPENDENT OF AGEPreprint
Zanini, B. M., Ávila, B. M., Hense, J. D., Garcia, D. N., Ashiqueali, S., Alves, P. M., Oliveira, T. L., Collares, T. V., Brieño‐Enríquez, M. A., Mason, J. B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.04.621842
Editorial for Special Issue “Cellular Senescence: Recent Cellular Advances and Discoveries”
Crasta, K., & Faggioli, F. (2024) · Biomedicines · doi:10.3390/biomedicines12122796
Packard, B. E., Roux, P. F., L’Heureux, S. C., & Zamboni, W. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.20.689131
Extracellular vesicles in health, aging and disease
Umeris, E., Webb, A., & Kovalchuk, I. (2026) · Oncoscience · doi:10.18632/oncoscience.673
Extracellular vesicle–mediated strategies for cancer tissue normalisation
Raudenská, M., Balvan, J., Gumulec, J., & Masařík, M. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218909
- Authors
- Lee, B.-R., Kim, J.-H., Choi, E.-S., Cho, J. H., & Kim, E.
- Affiliations
- Daegu Gyeongbuk Institute of Science and Technology (KR)
- Pohang University of Science and Technology (KR)
- Corresponding author
- Kim, Eunjoo
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2018-09
- Volume
- Volume 13
- Pages
- 5335-5345
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC6141108
- OpenAlex
- W2890285413
- Cited by
- 72
- References
- 43
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 13 · 2023: 10 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 5
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Daegu Gyeongbuk Institute of Science and Technology (18-BT-02, 18-LC-01)
- Ministry of Science and ICT, South Korea
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- exosomes, aging, extracellular vesicles, microRNA, reverse aging, telomerase, p16INK4a, mTOR, IGF-1 receptor, lung aging, liver aging, biomarkers, anti-aging therapy
- MeSH terms
- Aging, Animals, Injections, Liver, Lung, Male, Mice, Inbred C57BL, Down-Regulation, Telomerase, Gene Expression Profiling, MicroRNAs, Exosomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
