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Biodistribution, Clearance And Morphological Alterations Of Intravenously Administered Iron Oxide Nanoparticles In Male Wistar Rats
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INTRODUCTION: Nanoparticles are used worldwide because of their unique properties, with large-scale application in various fields, such as medicine, cosmetics and industries. In view of their widespread use, the potential adverse effects of nanoparticles have become a significant cause for concern, in terms of not only human health and safety but also the environment. The present investigation focused on establishing the bioaccumulation patterns and ultrastructural changes induced by retained iron oxide nanoparticles (IONPs) in various target organs of rats. METHODS: Twenty-four male Wistar rats were randomly divided into four groups. Experimental animals were intravenously administered different doses of IONPs (7.5 mg/kg, 15 mg/kg and 30 mg/kg) once in a week for 4 weeks. Urine and feces samples were collected on a daily basis to assess nanoparticle clearance and analyzed via atomic absorption spectroscopy (AAS). At the end of the experiment, rats were euthanized and different organs, including spleen, liver, kidney, lung, heart, testis and brain, were dissected. Bioaccumulation of iron in organs and ultrastructural changes induced by IONPs were determined. RESULTS: The maximal concentration of iron was detected in spleen and minimal concentration in the brain. The level of iron accumulation in organs was as follows: spleen>blood>liver>kidney>lung>heart>testis>brain. The excretion profile in urine revealed maximum excretion on the day following administration that was maintained until day 28, whereas the iron content in feces remained high during the first three days after injection. A similar pattern was observed throughout the duration of the experiment. Ultrastructural alterations were detected in spleen, kidney, lung, heart, testis, brain and liver, indicative of cellular damage induced by accumulating nanoparticles in these organs. CONCLUSION: Intravenous administration of IONPs results in ultrastructural changes and dose-dependent bioaccumulation in different organs of rats.
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“Their accumulation pattern in organs of rodent models was revealed as follows: spleen > blood > liver > kidney > lungs > heart > testis > brain.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [328]
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The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906
“Their accumulation pattern in organs of rodent models was revealed as follows: spleen > blood > liver > kidney > lungs > heart > testis > brain.(328) Covalent conjugation of targeting ligands, and/or polymeric materials such as PEG chains, carboxymethyl cellulose, dextran could distinctively facilitate the transport o…”
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Metadata
- Authors
- Gaharwar, U. S., Meena, R., & Rajamani, P.
- Affiliations
- Jawaharlal Nehru University (IN)
- Corresponding author
- Gaharwar, Usha Singh
- Meena, Ramovatar
- Rajamani, Paulraj
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2019-12
- Volume
- Volume 14
- Pages
- 9677-9692
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC6902883
- OpenAlex
- W2993868899
- Cited by
- 75
- References
- 57
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 7 · 2023: 10 · 2022: 15 · 2021: 14 · 2020: 10
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Jawaharlal Nehru University
- Advanced Instrumentation Research Facility
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- iron oxide nanoparticles, tissue distribution, nanoparticle clearance, bioaccumulation, ultrastructural changes, intravenous administration, dose-dependent toxicity, nanoparticle excretion, spleen, kidney, liver, lung, testis, brain, heart
- MeSH terms
- Animals, Brain, Ferric Compounds, Heart, HeLa Cells, Humans, Iron, Kidney, Liver, Lung, Male, Spleen, Testis, Tissue Distribution, Rats, Wistar, Metal Nanoparticles, Administration, Intravenous
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