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Cited by 154Electrospun Nanofibers in Biomedical ApplicationsSilk-based biomaterials and applicationsBone Tissue Engineering Materials

Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering

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Hajiali, Hadi, Shahgasempour, Naimi-Jamal, Mohammad Reza, Peirovi·2011·International Journal of Nanomedicine
DOI 10.2147/ijn.s24312PMC PMC3215154
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Abstract

BACKGROUND AND METHODS: In this study, gelatin was blended with polyglycolic acid (PGA) at different ratios (0, 10, 30, and 50 wt%) and electrospun. The morphology and structure of the scaffolds were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and differential scanning calorimetry. The mechanical properties were also measured by the tensile test. Furthermore, for biocompatibility assessment, human umbilical vein endothelial cells and human umbilical artery smooth muscle cells were cultured on these scaffolds, and cell attachment and viability were evaluated. RESULTS: PGA with 10 wt% gelatin enhanced the endothelial cells whilst PGA with 30 wt% gelatin increased smooth muscle cell adhesion, penetration, and viability compared with the other scaffold blends. Additionally, with the increase in gelatin content, the mechanical properties of the scaffolds were improved due to interaction between PGA and gelatin, as revealed by Fourier transform infrared spectroscopy and differential scanning calorimetry. CONCLUSION: Incorporation of gelatin improves the biological and mechanical properties of PGA, making promising scaffolds for vascular tissue engineering.

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  • Gelatin exhibits excellent biocompatibility and biodegradability.

    “Gelatin, a high-molecular-weight natural protein obtained from the hydrolysis of collagen, exhibits excellent biocompatibility and biodegradability [227,228].”

    From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [227]

    The Discussion reports improved vascular-cell compatibility when gelatin is added to PGA scaffolds at certain concentrations, supporting the biocompatibility part in that setting. The Introduction calls PGA biodegradable, but our copy does not establish gelatin’s biodegradability. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Authors
Hajiali, H., Shahgasempour, Naimi-Jamal, M. R., & Peirovi
Affiliations
  • Shahid Beheshti University (IR)
  • Shahid Beheshti University of Medical Sciences (IR)
Corresponding author
Hajiali, Hadi
ORCID
Hajiali, Hadi
Venue
International Journal of Nanomedicine
Publisher
Informa UK Limited
Published
2011-09
Volume
6
Pages
2133
ISSN
  • 1176-9114 (ISSN-L)
  • 1178-2013
DOI
10.2147/ijn.s24312
PMC
PMC3215154
OpenAlex
W2154042916
Cited by
154
References
1
Citations by year
2026: 6 · 2025: 9 · 2024: 8 · 2023: 7 · 2022: 17 · 2021: 7 · 2020: 9 · 2019: 23 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 15 · 2014: 15 · 2013: 11 · 2012: 6
FWCI
4.20
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Nanomedicine (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
polyglycolic acid, gelatin, electrospun nanofibers, nanofibrous scaffolds, vascular tissue engineering, endothelial cell adhesion, smooth muscle cells, mechanical properties, biocompatibility, polymer blends
MeSH terms
Biocompatible Materials, Calorimetry, Differential Scanning, Cell Adhesion, Cell Survival, Cells, Cultured, Gelatin, Humans, Polyglycolic Acid, Tensile Strength, Umbilical Arteries, Spectroscopy, Fourier Transform Infrared, Tissue Engineering, Nanotechnology, Tissue Scaffolds, Elastic Modulus, Nanofibers, Human Umbilical Vein Endothelial Cells

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