Fiber-based tissue engineering: progress, challenges, and opportunities
Open accessAbstract
Tissue engineering aims to improve the function of diseased or damaged organs by creating biological substitutes. To fabricate a functional tissue, the engineered construct should mimic the physiological environment including its structural, topographical, and mechanical properties. Moreover, the construct should facilitate nutrients and oxygen diffusion as well as removal of metabolic waste during tissue regeneration. In the last decade, fiber-based techniques such as weaving, knitting, braiding, as well as electrospinning, and direct writing have emerged as promising platforms for making 3D tissue constructs that can address the abovementioned challenges. Here, we critically review the techniques used to form cell-free and cell-laden fibers and to assemble them into scaffolds. We compare their mechanical properties, morphological features and biological activity. We discuss current challenges and future opportunities of fiber-based tissue engineering (FBTE) for use in research and clinical practice.
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Self-citation
Flagged first, then by citations
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Cited by
Sorted by citations
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
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“Recently, these techniques have been exte nsively used for engineering tissue engineering scaffolds with biomimetic mechanical pr operties [65-68].”
BackgroundMethodSelf-citationA liver-on-a-chip platform with bioprinted hepatic spheroids
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Self-citationMicrofluidic techniques for development of 3D vascularized tissue
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Self-citationComposite living fibers for creating tissue constructs using textile techniques
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Self-citationJetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement
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- Authors
- Tamayol, A., Akbari, M., Annabi, N., Paul, A., Khademhosseini, A., & Juncker, D.
- Affiliations
- McGill University and Génome Québec Innovation Centre (CA)
- Brigham and Women's Hospital (US)
- Corresponding author
- Khademhosseini, Ali
- Juncker, David
- Venue
- Biotechnology Advances
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 31
- Issue
- 5
- Pages
- 669-687
- ISSN
- 0734-9750 (ISSN-L)
- PMC
- PMC3631569
- OpenAlex
- W2092273436
- Cited by
- 458
- References
- 173
- Citations by year
- 2026: 11 · 2025: 24 · 2024: 21 · 2023: 27 · 2022: 29 · 2021: 33 · 2020: 37 · 2019: 45 · 2018: 53 · 2017: 44 · 2016: 62 · 2015: 30 · 2014: 34 · 2013: 8
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biotechnology Advances (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- National Heart, Lung, and Blood Institute (HL092836, HL-099073, R01HL099073, R01HL092836)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR057837, R01AR057837)
- National Institute of Biomedical Imaging and Bioengineering (R01EB012597, R21EB009196, EB008392, EB012597, R01EB008392)
- National Institute of Dental and Craniofacial Research (DE019024, DE021468, R01DE021468, RL1DE019024)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- electrospinning, direct writing, weaving, knitting, braiding, tissue engineering scaffolds, 3D tissue constructs, scaffold mechanical properties, scaffold morphology, tissue regeneration
- MeSH terms
- Animals, Biotechnology, Humans, Cell Culture Techniques, Tissue Engineering, Tissue Scaffolds
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