Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context

Tumour exosome integrins determine organotropic metastasis

Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101 · see citing works

Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems

Danaei, M., Dehghankhold, M., Ataei, S., Davarani, F. H., Javanmard, R., Dokhani, A., Khorasani, S., & Mozafari, M. R. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10020057 · Cited by 4,967 · see citing works

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathieu, M., Jaular, L. M., Lavieu, G., & Théry, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,776 · see citing works

Routes and mechanisms of extracellular vesicle uptake

Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832 · see citing works

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., Lee, J. J., & Kalluri, R. (2017) · Nature · doi:10.1038/nature22341 · Cited by 2,639 · see citing works

Exosomes as drug delivery vehicles for Parkinson’s disease therapy

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009 · see citing works

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003 · see citing works

Extracellular vesicles as a next-generation drug delivery platform

Herrmann, I. K., Wood, M. J. A., & Fuhrmann, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00931-2 · Cited by 1,951 · see citing works

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Wiklander, O. P. B., Nordin, J. Z., O'Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., Vader, P., Lee, Y., Sork, H., Seow, Y., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26316 · Cited by 1,730 · see citing works

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., & Wrana, J. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.024 · Cited by 1,311 · see citing works

Viral membrane fusion

Harrison, S. C. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1456 · Cited by 1,191 · see citing works

Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells

Morelli, A. E., Larregina, A. T., Shufesky, W. J., Sullivan, M. L. G., Stolz, D. B., Papworth, G. D., Zahorchak, A. F., Logar, A., Wang, Z., Watkins, S. C., et al. (2004) · Blood · doi:10.1182/blood-2004-03-0824 · Cited by 1,075 · see citing works

A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry

Shukla, D., Liu, J., Blaiklock, P., Shworak, N. W., Bai, X., Esko, J. D., Cohen, G. H., Eisenberg, R. J., ROSENBERG, R. D., & Spear, P. G. (1999) · Cell · doi:10.1016/s0092-8674(00)80058-6 · Cited by 1,053 · see citing works

Cellular Internalization of Exosomes Occurs Through Phagocytosis

Feng, D., Zhao, W.-L., Ye, Y.-Y., Bai, X., Liu, R.-Q., Chang, L.-F., Zhou, Q., & Sui, S. (2010) · Traffic · doi:10.1111/j.1600-0854.2010.01041.x · Cited by 981 · see citing works

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

Lai, C. P., Mardini, O., Ericsson, M., Prabhakar, S., Maguire, C. A., Chen, J. W., Tannous, B. A., & Breakefield, X. O. (2014) · ACS Nano · doi:10.1021/nn404945r · Cited by 894 · see citing works

Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy

Sokolova, V., Ludwig, A., Hornung, S., Rotan, O., Horn, P. A., Epple, M., & Giebel, B. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.05.013 · Cited by 853 · see citing works

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

Fitzner, D., Schnaars, M., van Rossum, D., Krishnamoorthy, G., Dibaj, P., Bakhti, M., Regen, T., Hanisch, U.-K., & Simons, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.074088 · Cited by 775 · see citing works

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

Tao, S., Yuan, T., Zhang, Y.-L., Yin, W., Guo, S., & Zhang, C. (2016) · Theranostics · doi:10.7150/thno.17133 · Cited by 734 · see citing works

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

Takahashi, Y., Nishikawa, M., Shinotsuka, H., Matsui, Y., Ohara, S., Imai, T., & Takakura, Y. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.03.013 · Cited by 729 · see citing works

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Murphy, D. E., de Jong, O. G., Brouwer, M., Wood, M. J. A., Lavieu, G., Schiffelers, R. M., & Vader, P. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0223-5 · Cited by 715 · see citing works

ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles

Rider, M. A., Hurwitz, S. N., & Meckes, D. G. (2016) · Scientific Reports · doi:10.1038/srep23978 · Cited by 699 · see citing works

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

Svensson, K. J., Christianson, H. C., Wittrup, A., Bourseau-Guilmain, E., Lindqvist, E., Svensson, L. M., Mörgelin, M., & Belting, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445403 · Cited by 690 · see citing works

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

Nazarenko, I. A., Rana, S., Baumann, A., McAlear, J., Hellwig, A., Trendelenburg, M. F., Lochnit, G., Preissner, K. T., & Zöller, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2470 · Cited by 686 · see citing works

Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

Zhang, S., Chu, W. C., Lai, R. C., Lim, S. K., Hui, J. H. P., & Toh, W. S. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.06.022 · Cited by 673 · see citing works

Quality and efficiency assessment of six extracellular vesicle isolation methods by nano-flow cytometry

Tian, Y., Gong, M., Hu, Y., Liu, H., Zhang, W., Zhang, M., Hu, X., Aubert, D., Zhu, S., Wu, L., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1697028 · Cited by 643 · see citing works

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

Kooijmans, S. A. A., Fliervoet, L. A. L., van der Meel, R., Fens, M. H. A. M., Heijnen, H. F. G., Henegouwen, P. M. P. V. B. E., Vader, P., & Schiffelers, R. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.009 · Cited by 629 · see citing works

Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source

Meng, W., He, C., Hao, Y., Wang, L., Li, L., & Zhu, G. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1748758 · Cited by 618 · see citing works

ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming

Segura, É., Nicco, C., Lombard, B., Véron, P., Raposo, G., Batteux, F., Amigorena, S., & Théry, C. (2005) · Blood · doi:10.1182/blood-2005-01-0220 · Cited by 614 · see citing works

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

Joshi, B. S., de Beer, M. A., Giepmans, B. N. G., & Zuhorn, I. S. (2020) · ACS Nano · doi:10.1021/acsnano.9b10033 · Cited by 585 · see citing works

Macrophage‐dependent clearance of systemically administered B16BL6‐derived exosomes from the blood circulation in mice

Imai, T., Takahashi, Y., Nishikawa, M., Kato, K., Morishita, M., Yamashita, T., Matsumoto, A., Charoenviriyakul, C., & Takakura, Y. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26238 · Cited by 584 · see citing works

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

Lai, C. P., Kim, E. Y., Badr, C. E., Weissleder, R., Mempel, T. R., Tannous, B. A., & Breakefield, X. O. (2015) · Nature Communications · doi:10.1038/ncomms8029 · Cited by 574 · see citing works

Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity

Haraszti, R. A., Miller, R., Stoppato, M., Sere, Y. Y., Coles, A., Didiot, M.-C., Wollacott, R., Sapp, E., Dubuke, M. L., Li, X., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.09.015 · Cited by 567 · see citing works

Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

Verdera, H. C., Gitz-Francois, J. J., Schiffelers, R. M., & Vader, P. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.019 · Cited by 557 · see citing works

Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomes Combined Pluronic F127 Hydrogel Promote Chronic Diabetic Wound Healing and Complete Skin Regeneration

Yang, J., Chen, Z., Pan, D.-Y., Li, H., & Shen, J. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s249129 · Cited by 523 · see citing works

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

Qi, H., Liu, C., Long, L., Ren, Y., Zhang, S., Chang, X., Qian, X., Jia, H., Zhao, J., Sun, J., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b06939 · Cited by 482 · see citing works

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

Heusermann, W., Hean, J., Trojer, D., Steib, E., von Bueren, S., Graff-Meyer, A., Genoud, C., Martin, K., Pizzato, N., Voshol, J., et al. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201506084 · Cited by 447 · see citing works

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

Dinh, P., Paudel, D., Brochu, H. N., Popowski, K. D., Gracieux-Singleton, M. C., Cores, J., Huang, K., Hensley, M. T., Harrell, E. A., Vandergriff, A. C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14344-7 · Cited by 441 · see citing works

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

Hoen, E. N. M. N., Buschow, S. I., Anderton, S. M., Stoorvogel, W., & Wauben, M. H. M. (2008) · Blood · doi:10.1182/blood-2008-08-174094 · Cited by 436 · see citing works

Display of GPI‐anchored anti‐EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

Kooijmans, S. A. A., Gomez‐Aleza, C., Roffler, S. R., van Solinge, W. W., Vader, P., & Schiffelers, R. M. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.31053 · Cited by 429 · see citing works

Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

Gao, X., Ran, N., Dong, X., Zuo, B., Yang, R., Zhou, Q., Moulton, H. M., Seow, Y., & Yin, H. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0195 · Cited by 426 · see citing works

Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

Long, Q., Upadhya, D., Hattiangady, B., Kim, D.-K., An, S. Y., Shuai, B., Prockop, D. J., & Shetty, A. K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703920114 · Cited by 401 · see citing works

Trehalose prevents aggregation of exosomes and cryodamage

Bösch, S., de Beaurepaire, L., Allard, M., Mosser, M., Heichette, C., Chrétien, D., Jégou, D., & Bach, J. (2016) · Scientific Reports · doi:10.1038/srep36162 · Cited by 399 · see citing works

Systemic administration of cell-free exosomes generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves functional recovery in rats after traumatic brain injury

Zhang, Y., Chopp, M., Zhang, Z. G., Katakowski, M., Xin, H., Qu, C., Ali, M. M., Mahmood, A., & Xiong, Y. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.08.003 · Cited by 394 · see citing works

Organotropism: new insights into molecular mechanisms of breast cancer metastasis

Chen, W., Hoffmann, A. D., Liu, H., & Liu, X. (2018) · npj Precision Oncology · doi:10.1038/s41698-018-0047-0 · Cited by 393 · see citing works

Molecular interactions at the surface of extracellular vesicles

Buzás, E. I., Tóth, E. Á., Sódar, B. W., & Szabó-Taylor, K. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0682-0 · Cited by 384 · see citing works

Qualitative differences in T‐cell activation by dendritic cell‐derived extracellular vesicle subtypes

Tkach, M., Kowal, J., Zucchetti, A. E., Enserink, L. N. F. L., Jouve, M. J., Lankar, D., Saitakis, M., Jaular, L. M., & Théry, C. (2017) · The EMBO Journal · doi:10.15252/embj.201696003 · Cited by 381 · see citing works

Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging

Grange, C., Tapparo, M., Bruno, S., Chatterjee, D., Quesenberry, P. J., Tetta, C., & Camussi, G. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1663 · Cited by 362 · see citing works

A System of Cytokines Encapsulated in ExtraCellular Vesicles

Fitzgerald, W., Freeman, M. L., Lederman, M. M., Vasilieva, E., Romero, R. J., & Margolis, L. B. (2018) · Scientific Reports · doi:10.1038/s41598-018-27190-x · Cited by 349 · see citing works

Dynamics of exosome internalization and trafficking

Tian, T., Zhu, Y., Hu, F., Wang, Y., Huang, N., & Xiao, Z. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24304 · Cited by 336 · see citing works

Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes

Cheng, Y., Zeng, Q., Han, Q., & Xia, W. (2019) · Protein & Cell · doi:10.1007/s13238-018-0529-4 · Cited by 336 · see citing works

Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis.

El-Sayed, A., & Harashima, H. (2013) · Molecular Therapy · doi:10.1038/mt.2013.54 · Cited by 319 · see citing works

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis

Headland, S. E., Jones, H. R., Norling, L. V., Kim, A., Souza, P. R., Corsiero, E., Gil, C. D., Nerviani, A., Dell’Accio, F., Pitzalis, C., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac5608 · Cited by 319 · see citing works

Role of the Small GTPase RAB7 in the Late Endocytic Pathway

Vitelli, R., Santillo, M., Lattero, D., Chiariello, M., Bifulco, M., Bruni, C. B., & Bucci, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4391 · Cited by 312 · see citing works

Endoplasmic reticulum–endosome contact increases as endosomes traffic and mature

Friedman, J. R., DiBenedetto, J. R., West, M., Rowland, A. A., & Voeltz, G. K. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-10-0733 · Cited by 311 · see citing works

Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses

Maroto, R., Zhao, Y., Jamaluddin, M., Popov, V. L., Wang, H., Kalubowilage, M., Zhang, Y., Luisi, J., Sun, H., Culbertson, C. T., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1359478 · Cited by 310 · see citing works

Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons

Chivet, M., Javalet, C., Laulagnier, K., Blot, B., Hemming, F. J., & Sadoul, R. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24722 · Cited by 307 · see citing works

Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions

Purushothaman, A., Bandari, S., Liu, J., Mobley, J. A., Brown, E. E., & Sanderson, R. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.686295 · Cited by 304 · see citing works

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

Nakase, I., & Futaki, S. (2015) · Scientific Reports · doi:10.1038/srep10112 · Cited by 297 · see citing works

Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity

Cheng, Q., Shi, X., Han, M., Smbatyan, G., Lenz, H., & Zhang, Y. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b10047 · Cited by 286 · see citing works

The roles of flotillin microdomains – endocytosis and beyond

Otto, G. P., & Nichols, B. J. (2011) · Journal of Cell Science · doi:10.1242/jcs.092015 · Cited by 278 · see citing works

Human umbilical cord mesenchymal stem cell derived exosomes encapsulated in functional peptide hydrogels promote cardiac repair

Han, C., Zhou, J., Liang, C., Liu, B., Pan, X., Zhang, Y., Wang, Y., Yan, B., Xie, W., Liu, F., et al. (2019) · Biomaterials Science · doi:10.1039/c9bm00101h · Cited by 278 · see citing works

Coculture of Human Mesenchymal Stem Cells and Articular Chondrocytes Reduces Hypertrophy and Enhances Functional Properties of Engineered Cartilage

Bian, L., Zhai, D. Y., Mauck, R. L., & Burdick, J. A. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0531 · Cited by 267 · see citing works

Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display

Antes, T. J., Middleton, R., Luther, K. M., Ijichi, T., Peck, K. A., Liu, W. J., Valle, J., Echavez, A. K., & Marbán, E. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0388-4 · Cited by 255 · see citing works

Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T‐lymphocyte responses and antitumour immunity

Hao, S., Bai, O., Li, F., Yuan, J., Laferté, S., & Xiang, J. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02483.x · Cited by 248 · see citing works

Engineered Exosomes for Targeted Transfer of siRNA to HER2 Positive Breast Cancer Cells

Khodashenas, S., Moghadam, M. F., Moazzeni, S. M., Gomari, H., & Salimi, F. (2018) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-018-2813-4 · Cited by 243 · see citing works

Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation

Chiou, N.-T., Kageyama, R., & Ansel, K. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.073 · Cited by 234 · see citing works

Manufacturing and characterization of extracellular vesicles from umbilical cord-derived mesenchymal stromal cells for clinical testing

Rohde, E., Pachler, K., & Gimona, M. (2019) · Cytotherapy · doi:10.1016/j.jcyt.2018.12.006 · Cited by 234 · see citing works

Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages

Matsumoto, A., Takahashi, Y., Nishikawa, M., Sano, K., Morishita, M., Charoenviriyakul, C., Saji, H., & Takakura, Y. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2016.07.022 · Cited by 234 · see citing works

Low pH increases the yield of exosome isolation

Ban, J.-J., Lee, M., Im, W., & Kim, M. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.03.172 · Cited by 225 · see citing works

To Protect and to Preserve: Novel Preservation Strategies for Extracellular Vesicles

Kusuma, G. D., Barabadi, M., Tan, J. L., Morton, D. A. V., Frith, J. E., & Lim, R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01199 · Cited by 222 · see citing works

Serotonin stimulates secretion of exosomes from microglia cells

Glebov, K., Löchner, M., Jabs, R., Lau, T., Merkel, O., Schloss, P., Steinhäuser, C., & Walter, J. (2015) · Glia · doi:10.1002/glia.22772 · Cited by 221 · see citing works

Hydrogel-Mediated Sustained Systemic Delivery of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improves Hepatic Regeneration in Chronic Liver Failure

Mardpour, S., Ghanian, M. H., Sadeghi-abandansari, H., Mardpour, S., Nazari, A., Shekari, F., & Baharvand, H. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b10126 · Cited by 211 · see citing works

Disruption of Circulating Extracellular Vesicles as a Novel Therapeutic Strategy against Cancer Metastasis

Nishida-Aoki, N., Tominaga, N., Takeshita, F., Sonoda, H., Yoshioka, Y., & Ochiya, T. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.10.009 · Cited by 208 · see citing works

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis

Shin, K., Ha, D. H., Kim, J. O., Crumrine, D. A., Meyer, J. M., Wakefield, J. S., Lee, Y., Kim, B., Kim, S., Kim, H.-K., et al. (2020) · Cells · doi:10.3390/cells9030680 · Cited by 208 · see citing works

Characterization of Uptake and Internalization of Exosomes by Bladder Cancer Cells

Franzen, C. A., Simms, P. E., Huis, A. F. V., Foreman, K. E., Kuo, P. C., & Gupta, G. N. (2014) · BioMed Research International · doi:10.1155/2014/619829 · Cited by 204 · see citing works

Dendritic Cell–Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity

Näslund, T. I., Gehrmann, U., Qazi, K. R., Karlsson, M. C. I., & Gabrielsson, S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203082 · Cited by 203 · see citing works

Genetically Engineered Liposome‐like Nanovesicles as Active Targeted Transport Platform

Zhang, P., Zhang, L., Qin, Z., Hua, S., Guo, Z., Chu, C., Lin, H., Zhang, Y., Li, W., Zhang, X., et al. (2017) · Advanced Materials · doi:10.1002/adma.201705350 · Cited by 201 · see citing works

Heparin affinity purification of extracellular vesicles

Balaj, L., Atai, N. A., Chen, W., Mu, D., Tannous, B. A., Breakefield, X. O., Skog, J., & Maguire, C. A. (2015) · Scientific Reports · doi:10.1038/srep10266 · Cited by 191 · see citing works

Size-dependent cellular uptake of exosomes

Caponnetto, F., Manini, I., Škrap, M., Palmai‐Pallag, T., Loreto, C. D., Beltrami, A. P., Cesselli, D., & Ferrari, E. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.12.009 · Cited by 182 · see citing works

Assessing the role of surface glycans of extracellular vesicles on cellular uptake

Williams, C., Pazos, R., Royo, F., González, E., Roura‐Ferrer, M., Martinez, A., Gamiz, J., Reichardt, N., & Falcón‐Pérez, J. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-48499-1 · Cited by 181 · see citing works

Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons

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ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells

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Exosomes: Methods for Isolation and Characterization in Biological Samples

Singh, S., Dansby, C., Agarwal, D., Bhat, P. D., Dubey, P. K., & Krishnamurthy, P. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3995-5_17 · Cited by 11 · see citing works

Overcoming biological barriers: Precision engineered extracellular vesicles for personalized neuromedicine

Ravichandiran, V., Kesharwani, A., Anupriya, Bhaskaran, M., Parihar, V. K., Bakhshi, S., Velayutham, R., & Kumarasamy, M. (2024) · Precision medicine and engineering. · doi:10.1016/j.preme.2024.100010 · Cited by 11 · see citing works

Extracellular vesicles in atherosclerosis cardiovascular disease: emerging roles and mechanisms

Deng, H., Qiu, W., Zhang, Y., & Hua, J. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1611557 · Cited by 11 · see citing works

Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes

Nair, S., Ormazábal, V., Carrión, F., Handberg, A., McIntyre, D. H., & Salomón, C. (2023) · Clinical Science · doi:10.1042/cs20220150 · Cited by 12 · see citing works

Bioengineering extracellular vesicles for enhanced therapeutic functionality and clinical potential in the cardiovascular system

Wang, Y., Hu, M., Spanos, M., Xu, S., Song, J., Li, G., Crețoiu, D., & Xiao, J. (2026) · 中国科学通报：英文版 · doi:10.1016/j.scib.2026.01.067 · Cited by 10 · see citing works

EV-out or EV-in: Tackling cell-to-cell communication within the tumor microenvironment to enhance anti-tumor efficacy using extracellular vesicle-based therapeutic strategies

Chiangjong, W., & Chutipongtanate, S. (2022) · OpenNano · doi:10.1016/j.onano.2022.100085 · Cited by 10 · see citing works

Exploring the potential of the convergence between extracellular vesicles and CAR technology as a novel immunotherapy approach

Bar, O., Porgador, A., & Cooks, T. (2024) · Journal of Extracellular Biology · doi:10.1002/jex2.70011 · Cited by 8 · see citing works

Harnessing Extracellular Vesicles for Targeted Drug Delivery in Ovarian Cancer

Yun, J., Noh, Y. R., Yoo, S., Park, S.-H., Choi, Y., An, J., & Kim, I. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17040528 · Cited by 6 · see citing works

Bioengineered extracellular vesicles: The path to precision medicine in liver diseases

Mittal, A., Jakhmola, V., & Baweja, S. (2025) · Liver Research · doi:10.1016/j.livres.2025.02.002 · Cited by 5 · see citing works

Boosting the Therapeutic Potential of Extracellular Vesicles Derived From Mesenchymal Stem Cells via Advanced Preconditioning for Neurodegenerative Disorders

D’Arrigo, C., Labbate, S., & Galante, D. (2025) · Stem Cells International · doi:10.1155/sci/2616653 · Cited by 5 · see citing works

The role of extracellular vesicles in animal reproduction

Golchin, A., Ojaroodi, A. F., Rezaeiani, S., Ghasemnejad‐Berenji, H., & Taheri‐Anganeh, M. (2026) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2025.104831 · Cited by 5 · see citing works

Bioreactor-enabled extracellular vesicle production for downstream functional engineering

Tripp, T. L., Vasile, K., Terrizzi, M., Cisneros, E. P., Volpatti, L. R., & Hisey, C. L. (2026) · Health Nanotechnology · doi:10.1186/s44301-026-00021-z · Cited by 6 · see citing works

A novel process for transcellular hemoglobin transport from macrophages to cancer cells

Braniewska, A., Skorzynski, M., Sas, Z., Długołęcka, M., Marszałek, I., Kurpiel, D., Bühler, M., Strzemecki, D., Karpińska, A., Białasek, M., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01929-8 · Cited by 4 · see citing works

Clinical potential of CAR T cell-derived extracellular vesicles (CAR-EVs) in cancer therapy: a cell-free approach

Kale, V. P., & Ingavle, G. C. (2025) · Therapeutic Delivery · doi:10.1080/20415990.2025.2569298 · Cited by 4 · see citing works

Exosomes in Autoimmunity: Mediators of Autoantigen Presentation and Targets for Therapeutic Intervention in Autoimmune Diseases

Almohaimeed, H. M., Almars, ‏. I., Tounsi, W. A., Mohammedsaleh, Z. M., Panigrahi, R., Singh, I., Singh, S., Dhara, B., & Uti, D. E. (2025) · Journal of Clinical Immunology · doi:10.1007/s10875-025-01965-0 · Cited by 4 · see citing works

Targeted tau protein degradation: a promising therapeutic approach for tauopathies

Baazaoui, N., Alfaifi, M. Y., Shati, A. A., Saad, R. B., & Garzoli, S. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.11.041 · Cited by 4 · see citing works

Harnessing the potential of aptamers in cell-derived vesicles for targeting colorectal cancers at Pan-Dukes' stages

Lee, E. S., Cha, B. S., Jang, Y. J., Woo, J. S., Kim, S., Park, S., Oh, S. W., & Park, K. S. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135911 · Cited by 4 · see citing works

Orally Delivered Milk-Derived Nanovesicles Loaded with Connexin 43 Peptides for Targeted Cardiac Ischemia-Reperfusion TherapyPreprint

Marsh, S. R., Amin, M. R., Toldo, S. A., Beard, C. E., Dogan, A. B., Mezzaroma, E., Andres, E., Stout, R. F., Bannon, M. S., Payne, L. B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.01.630994 · Cited by 4 · see citing works

Mechanisms Tackling Salivary Gland Diseases with Extracellular Vesicle Therapies

Sawutdeechaikul, P., Hwang, S., Klangprapan, S., Phan, T. V., Lam, C. B., Yoon, Y., Seo, S., Hong, S., Lim, J., & Ferreira, J. N. (2025) · Journal of Dental Research · doi:10.1177/00220345251319295 · Cited by 3 · see citing works

Extracellular vesicles derived from MSCs carrying dexamethasone alleviate inflammatory damage in septic mice

Mirsanei, Z., Jamshidi‐Adegani, F., Vakilian, S., Elumalai, P., Hazrati, A., Soufihasanabad, S., Ahangari, F., Karima, S., Salmani, F., Asl, P. E., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178042 · Cited by 2 · see citing works

CAF-derived exosomes: orchestrators of dysregulated signaling pathways in breast cancer progression

Hameed, A. K., Rab, S. O., Ahmed, T. A., Chandra, M., Mohammed, J. S., RenukaJyothi, S., Nayak, P. P., Tomar, P., Hussn, A., & Ali, A. F. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04635-5 · Cited by 2 · see citing works

Efficacy and Safety of Mesenchymal Stromal Cell-derived Extracellular Vesicles: A Systematic Review and Meta-analysis of Human Clinical Trials

Mussin, N. M., Zhilisbayeva, K. R., Baspakova, A. M., Karimsakova, B. K., Tulegenova, G., Kurmanalina, M. A., & Amin, T. (2026) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-025-00532-8 · Cited by 2 · see citing works

Plant-derived extracellular vesicles as a promising nanomedicine platform: engineering strategies and biomedical applications

Zhang, X., Dong, Y., Tian, Q., Yang, Y., Wang, H., Zhang, M., Li, Y., Li, X., Chen, Q., Guo, D., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.173834 · Cited by 2 · see citing works

Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence

Jia, X., Hu, X., Fu, Z., Zhang, L., Luo, X., Huang, W., Hua, Y., Fang, Q., Zeng, J., Huang, F., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124109 · Cited by 2 · see citing works

Redefining long-acting injectables: the emerging role of extracellular vesicles in sustained drug delivery

Mathlouthi, S., Szczepański, A., Pesce, C., Malfanti, A., Kuryk, Ł., & Garofalo, M. (2026) · Drug Delivery and Translational Research · doi:10.1007/s13346-026-02117-6 · Cited by 2 · see citing works

Towards Extracellular Vesicles in the Treatment of Epidermolysis Bullosa

Sandoval, A. G. W., & Badiavas, E. V. (2025) · Bioengineering · doi:10.3390/bioengineering12060574 · Cited by 2 · see citing works

Atheroprone shear stress stimulates noxious endothelial extracellular vesicle uptake by MCAM and PECAM-1 cell adhesion moleculesPreprint

Coly, P., Chatterjee, S., Mezine, F., Jekmek, K. E., Devue, C., Nipoti, T., Corona, M. L., Dingli, F., Loew, D., van Niel, G., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.31.522373 · Cited by 2 · see citing works

Producing highly effective extracellular vesicles using IBAR and talin F3 domain fusion

Lee, J., Lee, M., Kim, J., Cho, E., & Kim, C. (2024) · Animal Cells and Systems · doi:10.1080/19768354.2024.2353159 · Cited by 1 · see citing works

Osteoimmunomodulation of astragalus-calcium silicate scaffolds-activated M2 macrophage-derived miR-218-rich exosome for enhanced bone regeneration

Chen, C.-Y., Lee, J., Lin, Y.-H., Kuo, T.-Y., Cho, D., & Shie, M. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102286 · Cited by 1 · see citing works

New models for cancer cachexia and their application to drug discovery

Sato, R., Anker, M. S., Springer, J., & von Haehling, S. (2025) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2025.2562020 · Cited by 1 · see citing works

Extracellular Vesicles Mediate Glucose Regulation by GLUT4-Overexpressing Engineered Muscle Tissue in T2D Mice

Shoyhet, H., Cohen, Y., Herman-Bachinsky, Y., Rosenhek‐Goldian, I., Kamyshinsky, R., Hornstein, E., & Levenberg, S. (2026) · ACS Nano Medicine · doi:10.1021/acsnanomed.5c00052 · Cited by 1 · see citing works

3D-printed scaffolds encapsulating red-blood-cell-derived extracellular vesicles for microRNA delivery

Huang, C., Jayasinghe, M. K., Ramanujam, V., Lau, K., Le, M. T. N., & Chew, S. Y. (2026) · Cell Biomaterials · doi:10.1016/j.celbio.2026.100384 · Cited by 1 · see citing works

Extracellular vesicles as xenobiotic-metabolizing enzyme carriers: a new paradigm for brain drug metabolism

Tom, V. V., Jose, A. M., SASIDHARAN, A., Somayaji, Y., & Fernandes, R. (2026) · Drug Metabolism Reviews · doi:10.1080/03602532.2026.2666163 · Cited by 1 · see citing works

Zunajcelični vezikli – majhni delci, ogromen potencial

Holcar, M., & Keber, M. M. (2022) · Alternator · doi:10.3986/alternator.2022.34 · Cited by 1 · see citing works

Understanding the Molecular Actions of Spike Glycoprotein in SARS-CoV-2 and Issues of a Novel Therapeutic Strategy for the COVID-19 Vaccine

Matsuzaka, Y., & Yashiro, R. (2024) · BioMedInformatics · doi:10.3390/biomedinformatics4020084 · Cited by 1 · see citing works

An Overview of Extracellular Vesicles

Tassinari, S., & Grange, C. (2025) · Stem cells in clinical applications · doi:10.1007/978-3-031-90698-5_1

Red Blood Cell Extracellular Vesicles as Key Players in Thromboinflammation

Noubouossie, D. F., & Key, N. S. (2025) · Seminars in Thrombosis and Hemostasis · doi:10.1055/a-2664-0871

3D-Printed Scaffolds Encapsulating Red Blood Cell Extracellular Vesicles for MicroRNA DeliveryPreprint

Huang, C., Jayasinghe, M. K., Ramanujam, V., Lau, K., Le, M. T. N., & Chew, S. Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.31.667777

Therapeutic potential of extracellular mitochondria: applications and challenges

Mas‐Bargues, C., Huete-Acevedo, J., Arnal-Forné, M., Atencia-Rabadán, S., de Santiago-Montesinos, J., Dorosz, K., & Borrás, C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29283-5.00009-1

Human breast milk extracellular vesicles from donors with asthma differentially the modulate release of inflammatory cytokines by primary human airway smooth muscle cells in a recipient-cell specific mannerPreprint

Souza, T. F. G., Pierdoná, T. M., Seif, S., Bydak, B., Obi, P. O., Gordon, J. W., Turvey, S. E., Simons, E., Mandhane, P. J., Moraes, T. J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.02.709065

Production de Vésicules Extracellulaires à visée thérapeutique et application via une compresse d'alginate de calcium pour le traitement des grands brûlés

Lorenzini, B. (2023) · theses.fr (ABES) · doi:10.70675/134e1138za606z4df3za1d9z8c68cf78575f

The AMPK-BECN1-System Xc⁻ Pathway in Traumatic Brain Injury: Implications for Exosome-Based Therapy

Yan, S., Chen, W., Huang, Y., Jiang, N., Liu, Y., & Liu, W. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01719-5

Emerging applications of extracellular vesicles in regenerative medicine and tissue engineering

Sharma, S., Garg, N., & Dora, C. P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36641-3.00011-5

Cell-derived nanomaterials for acute kidney injury: a pathophysiology-driven framework for precision delivery and multimodal therapy

Zheng, Y., Li, Q., Liu, Y., Huang, Q., Peng, Y. K. M., Li, X., Zhang, R., Li, R., Zhou, X., & Lou, J. (2026) · Journal of drug targeting · doi:10.1080/1061186x.2026.2684024

Exosomes in Ovarian Cancer: Promoters, Biomarkers, and Therapeutic Targets

Wang, F., Dong, H., Song, Y., & Zhang, Y. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s606735 · Cited by 1 · see citing works

Extracellular Vesicle Translational Research

Hardenia, A., Zahiri, M., Afkhami, H., Bagheri, M. S., Reza, M. A. S., Yang, P., & Sheykhhasan, M. (2026) · Molecular and translational medicine · doi:10.1007/978-3-032-23810-8_13

Trophoblast derived extracellular vesicles trigger secondary vesicle release from endometrial epithelial cells

Muhandiram, S., Mousavi, S. O. R., Kodithuwakku, S. P., Godakumara, K., Kopanchuk, S., Rinken, A., Midekessa, G., & Fazeli, A. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-03096-4

Surface Functionalization of Small Extracellular Vesicles Derived from Caco-2 and HEK293T Cells in the Neutralization of Shiga Toxin 1 Subunit B

Mikolajczyk, K. P., Bereźnicka, A., Czernek, L., Gualerzi, A., Forleo, L., Bedoni, M., Łodej, N., & Migdał, P. (2026) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6c00243

From pathogenic to reparative: Context-Dependent function of extracellular vesicles in osteoarthritis

Yang, Z., Lin, Q., Li, H., Xiao, S., Ma, H., Lin, J., & Xing, D. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.09.005

Understanding exosomes: A history of EV ‐erything

Miron, R. J., Ahmad, P., & Sculean, A. (2026) · Periodontology 2000 · doi:10.1111/prd.70092

Current status of extracellular vesicle technology in industrialization and commercialization

Wu, Y. (2026) · Discover Nano · doi:10.1186/s11671-026-04862-6

Not All EVs Are Equal: Functional Heterogeneity of Extracellular Vesicles in Neuroregenerative Therapies

Chodkowska-Michalowska, M., Hawryluk, O., Lakomy, S., Słysz, A., & Sarnowska, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219731

Cellular Uptake of Engineered Extracellular Vesicles: Biomechanisms, Engineered Strategies, and Disease Treatment

Xie, Q., Hao, Y., Li, N., Song, H., Chen, X., Zhou, Z., Wang, J., Zhang, Y., Li, H., Han, P., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202302280 · Cited by 54 · see citing works

Molecular engineering of extracellular vesicles for drug delivery: Strategies, challenges, and perspectives

Dave, K. M., Pinky, P. P., & Manickam, D. S. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114068 · Cited by 78 · see citing works

Advances of engineered extracellular vesicles-based therapeutics strategy

Komuro, H., Aminova, S., Lauro, K., & Harada, M. (2022) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2022.2133342 · Cited by 53 · see citing works

Engineered extracellular vesicles: From design strategies to therapeutic applications

Meng, F., Deng, Y., Li, W., Zheng, A., Lu, M., & Xing, H. (2026) · Extracellular Vesicle · doi:10.1016/j.vesic.2026.100104 · Cited by 7 · see citing works

Engineered extracellular vesicles: pharmacological barriers, engineering strategies, and translational opportunities

Xu, J., Li, Z., Liu, D., Zhao, L., & Li, Y. (2026) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2026.85