Cited by 114Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsDrug Solubulity and Delivery Systems

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Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior

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Bikiaris, Dimitrios, Karavelidis, Karavas, Giliopoulos, Papadimitriou·2011·International Journal of Nanomedicine

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Abstract

Four new polyesters based on 1,3-propanediol and different aliphatic dicarboxylic acids were used to prepare ropinirole HCl-loaded nanoparticles. The novelty of this study lies in the use of polyesters with similar melting points but different degrees of crystallinity, varying from 29.8% to 67.5%, as drug nanocarriers. Based on their toxicity to human umbilical vein endothelial cells, these aliphatic polyesters were found to have cytotoxicity similar to that of polylactic acid and so may be considered as prominent drug nanocarriers. Drug encapsulation in polyesters was performed via an emulsification/solvent evaporation method. The mean particle size of drug-loaded nanoparticles was 164-228 nm, and the drug loading content was 16%-23%. Wide angle X-ray diffraction patterns showed that ropinirole HCl existed in an amorphous state within the nanoparticle polymer matrices. Drug release diagrams revealed a burst effect for ropinirole HCl in the first 6 hours, probably due to release of drug located on the nanoparticle surface, followed by slower release. The degree of crystallinity of the host polymer matrix seemed to be an important parameter, because higher drug release rates were observed in polyesters with a low degree of crystallinity.

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“These results are in accordance with the previous study (Karavelidis et al., 2011), which proved that the ZA release rate is amplified by lowering the crystallinity of the polymer matrix.”
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Authors: Bikiaris, D., Karavelidis, Karavas, Giliopoulos, & Papadimitriou
Affiliations: Aristotle University of Thessaloniki (GR)
Pharmathen (Greece) (GR)
Corresponding author: Bikiaris, Dimitrios
ORCID: Bikiaris, Dimitrios
Venue: International Journal of Nanomedicine
Publisher: Informa UK Limited
Published: 2011-11
Volume: 6
Pages: 3021
ISSN: 1176-9114 (ISSN-L)
1178-2013
DOI: 10.2147/ijn.s26016
PMC: PMC3230569
OpenAlex: W2012005393
Cited by: 111
References: 41
Citations by year: 2026: 3 · 2025: 3 · 2024: 10 · 2023: 12 · 2022: 18 · 2021: 12 · 2020: 18 · 2019: 6 · 2018: 11 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 4
FWCI: 1.31
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/3.0/ (vor)
Locations: International Journal of Nanomedicine (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords: polyester nanoparticles, crystallinity, ropinirole hydrochloride, drug release kinetics, 1,3-propanediol, aliphatic dicarboxylic acids, biocompatible nanocarriers, cytotoxicity, human umbilical vein endothelial cells, emulsion solvent evaporation, drug encapsulation, burst release, amorphous drug loading
MeSH terms: Biocompatible Materials, Cell Survival, Delayed-Action Preparations, Drug Stability, Humans, Indoles, Particle Size, Polyesters, Viscosity, X-Ray Diffraction, Nanocapsules, Human Umbilical Vein Endothelial Cells

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Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior

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