The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Evaluating the effects of crystallinity in new biocompatible polyester nanocarriers on drug release behavior
Open accessAbstract
Four new polyesters based on 1,3-propanediol and different aliphatic dicarboxylic acids were used to prepare ropinirole HCl-loaded nanoparticles. The novelty of this study lies in the use of polyesters with similar melting points but different degrees of crystallinity, varying from 29.8% to 67.5%, as drug nanocarriers. Based on their toxicity to human umbilical vein endothelial cells, these aliphatic polyesters were found to have cytotoxicity similar to that of polylactic acid and so may be considered as prominent drug nanocarriers. Drug encapsulation in polyesters was performed via an emulsification/solvent evaporation method. The mean particle size of drug-loaded nanoparticles was 164-228 nm, and the drug loading content was 16%-23%. Wide angle X-ray diffraction patterns showed that ropinirole HCl existed in an amorphous state within the nanoparticle polymer matrices. Drug release diagrams revealed a burst effect for ropinirole HCl in the first 6 hours, probably due to release of drug located on the nanoparticle surface, followed by slower release. The degree of crystallinity of the host polymer matrix seemed to be an important parameter, because higher drug release rates were observed in polyesters with a low degree of crystallinity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These results are in accordance with the previous study (Karavelidis et al., 2011), which proved that the ZA release rate is amplified by lowering the crystallinity of the polymer matrix.”
From Osteogenesis Improvement of Gelatin-Based Nanocomposite Scaffold by Loading Zoledronic Acid (2022) · cites this paper as Karavelidis et al., 2011
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Biodegradable polymers as biomaterials
Nair, L. S., & Laurencin, C. T. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.017 · Cited by 4,416
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Panyam, J., & Labhasetwar, V. D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00228-4 · Cited by 3,417
Biodegradable Long-Circulating Polymeric Nanospheres
Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,951
Micellar Nanocarriers: Pharmaceutical Perspectives
Torchilin, V. P. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9132-0 · Cited by 1,910
Polymer nanoparticles: Preparation techniques and size-control parameters
Rao, J. P., & Geckeler, K. E. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.01.001 · Cited by 1,731
Athanasiou, K. A., Niederauer, G. G., & Agrawal, C. M. (1996) · Biomaterials · doi:10.1016/0142-9612(96)85754-1 · Cited by 1,497
Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles
Reis, C. P., Neufeld, R. J., Ribeiro, A. J., & Veiga, F. (2006) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2005.12.003 · Cited by 1,355
Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
des Rieux, A., Fievez, V., Garinot, M., Schneider, Y.-J., & Préat, V. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.08.013 · Cited by 1,305
Nanotechnology: Intelligent Design to Treat Complex Disease
Couvreur, P., & Vauthier, C. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-0284-8 · Cited by 992
Cited by
Sorted by citations
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070
Drug delivery systems and materials for wound healing applications
Saghazadeh, S., Rinoldi, C., Schot, M., Kashaf, S. S., Sharifi, F., Jalilian, E., Nuutila, K., Giatsidis, G., Mostafalu, P., Derakhshandeh, H., et al. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.04.008 · Cited by 888
Tite, T., Popa, A.-C., Balescu, L. M., Chirică, I. M., Pasuk, I., Ferreira, J. M. F., & Stan, G. E. (2018) · Materials · doi:10.3390/ma11112081 · Cited by 287
Drug Carrier for Photodynamic Cancer Therapy
Debele, T. A., Peng, S., & Tsai, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160922094 · Cited by 245
Jha, R., & Mayanovic, R. A. (2023) · Nanomaterials · doi:10.3390/nano13081302 · Cited by 201
Metadata
- Authors
- Bikiaris, D., Karavelidis, Karavas, Giliopoulos, & Papadimitriou
- Affiliations
- Aristotle University of Thessaloniki (GR)
- Pharmathen (Greece) (GR)
- Corresponding author
- Bikiaris, Dimitrios
- ORCID
- Bikiaris, Dimitrios
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2011-11
- Volume
- 6
- Pages
- 3021
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC3230569
- OpenAlex
- W2012005393
- Cited by
- 111
- References
- 41
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 10 · 2023: 12 · 2022: 18 · 2021: 12 · 2020: 18 · 2019: 6 · 2018: 11 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- polyester nanoparticles, crystallinity, ropinirole hydrochloride, drug release kinetics, 1,3-propanediol, aliphatic dicarboxylic acids, biocompatible nanocarriers, cytotoxicity, human umbilical vein endothelial cells, emulsion solvent evaporation, drug encapsulation, burst release, amorphous drug loading
- MeSH terms
- Biocompatible Materials, Cell Survival, Delayed-Action Preparations, Drug Stability, Humans, Indoles, Particle Size, Polyesters, Viscosity, X-Ray Diffraction, Nanocapsules, Human Umbilical Vein Endothelial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
