The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures
Open accessAbstract
Cellular internalization and trans-barrier transport of nanoparticles can be manipulated on the basis of the physicochemical and mechanical characteristics of nanoparticles. Research has shown that these factors significantly influence the uptake of nanoparticles. Dictating these characteristics allows for the control of the rate and extent of cellular uptake, as well as delivering the drug-loaded nanosystem intra-cellularly, which is imperative for drugs that require a specific cellular level to exert their effects. Additionally, physicochemical characteristics of the nanoparticles should be optimal for the nanosystem to bypass the natural restricting phenomena of the body and act therapeutically at the targeted site. The factors at the focal point of emerging smart nanomedicines include nanoparticle size, surface charge, shape, hydrophobicity, surface chemistry, and even protein and ligand conjugates. Hence, this review discusses the mechanism of internalization of nanoparticles and ideal nanoparticle characteristics that allow them to evade the biological barriers in order to achieve optimal cellular uptake in different organ systems. Identifying these parameters assists with the progression of nanomedicine as an outstanding vector of pharmaceuticals.
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Cites
The effect of particle design on cellular internalization pathways
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Endocytosis unplugged: Multiple ways to enter the cell
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A contemporary concept of the blood-aqueous barrier
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Metadata
- Authors
- Pillay, V., Murugan, K., Choonara, Y. E., Kumar, P., Bijukumar, D., & du Toit, L. C.
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2015-03
- Volume
- 10
- Pages
- 2191
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- OpenAlex
- W2090471829
- Cited by
- 175
- References
- 8
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pillay, V., Murugan, K., Choonara, Y. E., Kumar, P., Bijukumar, D., & du Toit, L. C. (2015). Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures. International Journal of Nanomedicine. https://doi.org/10.2147/ijn.s75615
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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