The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps
Open accessAbstract
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a predominantly type 2 inflammation-mediated disease of the nasal mucosa and paranasal sinuses with an under-recognized clinical, humanistic, and economic burden. Patients with CRSwNP experience a high symptom burden, including nasal congestion, loss of smell, and rhinorrhea, which has a negative impact on physical and mental health-related quality of life, including sleep quality. Existing medical and surgical interventions, including local and systemic corticosteroids and endoscopic sinus surgery, may be associated with recurrence of nasal polyps and associated symptoms and with an increased risk of short- and long-term adverse effects, especially with repeated or long-term use. Because type 2 inflammation is implicated in the pathogenesis of several coexisting diseases, patients with CRSwNP often have comorbid asthma and/or nonsteroidal anti-inflammatory drug-exacerbated respiratory disease. These patients, as well as those with high corticosteroid use and/or sinonasal surgical history, have more severe disease and associated symptom burden and represent a difficult-to-treat population under the existing management paradigm. This article reviews the clinical, humanistic, and economic burden of CRSwNP; it highlights the unmet need for effective and safe CRSwNP therapies that effectively control symptoms and minimize recurrence by targeting the underlying type 2 inflammatory disease pathophysiology.
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European Position Paper on Rhinosinusitis and Nasal Polyps 2020
Fokkens, W. J., Lund, V. J., Hopkins, C., Hellings, P. W., Kern, R., Reitsma, S., Toppila-Salmi, S., Bernal-Sprekelsen, M., Mullol, J., Alobid, I., et al. (2020) · Rhinology journal · doi:10.4193/rhin20.600 · Cited by 5,882
Self-citationBachert, C., Han, J. K., Desrosiers, M., Hellings, P. W., Amin, N., Lee, S. E., Mullol, J., Greos, L. S., Bosso, J. V., Laidlaw, T. M., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31881-1 · Cited by 1,563
Self-citationEPOS2020: A Major Step Forward
Fokkens, W. J. (2020) · Rhinology journal · doi:10.4193/rhin20.401 · Cited by 1,240
Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers
Tomassen, P., Vandeplas, G., Van Zele, T., Cardell, L.-O., Arebro, J., Olze, H., Förster-Ruhrmann, U., Kowalski, M. L., Olszewska-Ziąber, A., Holtappels, G., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.12.1324 · Cited by 1,162
Self-citationChronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study
Hastan, D., Fokkens, W. J., Bachert, C., Newson, R. B., Bislimovska, J., Bockelbrink, A., Bousquet, P. J., Brozek, G., Bruno, A., Dahlén, S. E., et al. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02646.x · Cited by 1,112
Self-citationInternational Consensus Statement on Allergy and Rhinology: Rhinosinusitis
Orlandi, R. R., Kingdom, T. T., Hwang, P. H., Smith, T. L., Alt, J. A., Baroody, F. M., Batra, P. S., Bernal‐Sprekelsen, M., Bhattacharyya, N., Chandra, R. K., et al. (2016) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21695 · Cited by 892
Self-citationWaljee, A. K., Rogers, M. A. M., Lin, P., Singal, A. G., Stein, J. D., Marks, R. M., Ayanian, J. Z., & Nallamothu, B. K. (2017) · BMJ · doi:10.1136/bmj.j1415 · Cited by 830
Bachert, C., Mannent, L., Naclerio, R. M., Mullol, J., Ferguson, B. J., Gevaert, P., Hellings, P., Jiao, L., Wang, L., Evans, R. R., et al. (2016) · JAMA · doi:10.1001/jama.2015.19330 · Cited by 794
Self-citationEfficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials
Gevaert, P., Omachi, T. A., Corren, J., Mullol, J., Han, J., Lee, S. E., Kaufman, D., Ligueros-Saylan, M., Howard, M., Zhu, R., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.05.032 · Cited by 739
Self-citationTotal and specific IgE in nasal polyps is related to local eosinophilic inflammation
Bachert, C., Gevaert, P., Holtappels, G., Johansson, S. G. O., & van Cauwenberge, P. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112374 · Cited by 702
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Airways Type-2 Related Disorders: Multiorgan, Systemic or Syndemic Disease?
Giombi, F., Pace, G. M., Pirola, F., Cerasuolo, M., Ferreli, F., Mercante, G., Spriano, G., Canonica, G. W., Heffler, E., Ferri, S., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020730 · Cited by 25
Metadata
- Authors
- Bachert, C., Bhattacharyya, N., Desrosiers, M., & Khan, A. H.
- Venue
- Journal of Asthma and Allergy
- Publisher
- Informa UK Limited
- Published
- 2021-02
- Volume
- Volume 14
- Pages
- 127-134
- ISSN
- 1178-6965 (ISSN-L)
- OpenAlex
- W3126598211
- Cited by
- 294
- References
- 63
- FWCI
- 29.67
- Type
- journal article
- Language
- en
- Open access
- gold
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