The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Role of Wnt/β-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance
Open accessAbstract
Hepatocellular carcinoma (HCC) is one of the most common primary hepatic malignancies and one of the fastest-growing causes of cancer-related mortality in the United States. The molecular basis of HCC carcinogenesis has not been clearly identified. Among the molecular signaling pathways implicated in the pathogenesis of HCC, the Wnt/β-catenin signaling pathway is one of the most frequently activated. A great effort is under way to clearly understand the role of this pathway in the pathogenesis of HCC and its role in the transition from chronic liver diseases, including viral hepatitis, to hepatocellular adenomas (HCAs) and HCCs and its targetability in novel therapies. In this article, we review the role of the β-catenin pathway in hepatocarcinogenesis and progression from chronic inflammation to HCC, the novel potential treatments targeting the pathway and its prognostic role in HCC patients, as well as the imaging features of HCC and their association with aberrant activation of the pathway.
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Citations
Cites
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
Genetic landscape and biomarkers of hepatocellular carcinoma
Zucman-Rossi, J., Villanueva, A., Nault, J.-C., & Llovet, J. M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.061 · Cited by 1,325
Zucman-Rossi, J., Benhamouche, S., Godard, C., Boyault, S., Grimber, G., Balabaud, C., Cunha, A. S., Bioulac-Sage, P., & Perret, C. (2007) · Oncogene · doi:10.1038/sj.onc.1209824 · Cited by 256
Cited by
Gajos-Michniewicz, A., & Czyz, M. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2023.02.050 · Cited by 89
Wang, M., Yan, X., Dong, Y., Li, X., & Gao, B. (2024) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1012113 · Cited by 9
Metadata
- Authors
- Khalaf, A. M., Fuentes, D., Morshid, A. I., Burke, M. R., Kaseb, A. O., Hassan, M., Hazle, J. D., & Elsayes, K. M.
- Venue
- Journal of Hepatocellular Carcinoma
- Publisher
- Informa UK Limited
- Published
- 2018-06
- Volume
- Volume 5
- Pages
- 61-73
- ISSN
- 2253-5969 (ISSN-L)
- OpenAlex
- W2811009228
- Cited by
- 227
- References
- 3
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- gold
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