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Cited by 197Immune Response and InflammationInflammasome and immune disordersInflammatory Bowel Disease

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NOD2 and inflammation: current insights

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Negroni, Anna, Pierdomenico, Maria, Cucchiara, Salvatore, Stronati, Laura·2018·Journal of Inflammation Research
DOI 10.2147/jir.s137606PMC PMC5813767
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Abstract

The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory transcriptional program and other innate immune pathways, including autophagy and endoplasmic reticulum stress. An inactive form due to mutations or a constitutive high expression of NOD2 is associated with several inflammatory diseases, suggesting that balanced NOD2 signaling is critical for the maintenance of immune homeostasis. In this review, we discuss recent developments about the pathway and mechanisms of regulation of NOD2 and illustrate the principal functions of the gene, with particular emphasis on its central role in maintaining the equilibrium between intestinal microbiota and host immune responses to control inflammation. Furthermore, we survey recent studies illustrating the role of NOD2 in several inflammatory diseases, in particular, inflammatory bowel disease, of which it is the main susceptibility gene.

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Crossref · 10.2147/jir.s137606

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  • Stimulation of NOD2 upon bacterial invasion activates NF-kB signaling and may lead to caspase-1-dependent IL-1β secretion, similar to events downstream of NLRP3 inflammasome activation.

    “Stimulation of NOD2 upon bacterial invasion activates NF-kB signaling and may lead to caspase-1-dependent IL-1β secretion, similar to the events downstream of NLRP3 inflammasome activation [129].”

    From Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease (2023) · cites this paper as [129]

    The Introduction’s “NOD2 signaling” section says bacterial peptidoglycan activates NOD2 and NF-κB, and reports caspase-1-dependent IL-1β secretion during bacterial infection. It describes a NOD2–NLRP1 complex, however, and does not support the sentence’s comparison with events downstream of NLRP3 inflammasome activation (no page number provided in our copy). (LLM, conf=0.84)

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Metadata

Authors
Negroni, A., Pierdomenico, M., Cucchiara, S., & Stronati, L.
Affiliations
  • National Agency for New Technologies, Energy and Sustainable Economic Development (IT)
  • Sapienza University of Rome (IT)
Corresponding author
Stronati, Laura
ORCID
Venue
Journal of Inflammation Research
Publisher
Informa UK Limited
Published
2018-02
Volume
Volume 11
Pages
49-60
ISSN
1178-7031 (ISSN-L)
DOI
10.2147/jir.s137606
PMC
PMC5813767
OpenAlex
W2788262523
Cited by
197
References
9
Citations by year
2026: 13 · 2025: 29 · 2024: 17 · 2023: 32 · 2022: 36 · 2021: 31 · 2020: 24 · 2019: 8 · 2018: 7
FWCI
1.79
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Inflammation Research (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
  • ENEA Open Archive (National Agency for New Technologies, Energy and Sustainable Economic Development) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords
NOD2, NOD-like receptors, peptidoglycan sensing, innate immunity, autophagy, endoplasmic reticulum stress, inflammatory bowel disease, gut microbiota, immune homeostasis, inflammatory diseases, susceptibility genes

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