NOD proteins: regulators of inflammation in health and disease

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591 · see citing works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

The International IBD Genetics Consortium (IIBDGC), Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., McGovern, D. P., Hui, K. Y., Lee, J. C., Philip Schumm, L., Sharma, Y., et al. (2012) · Nature · doi:10.1038/nature11582 · Cited by 4,722 · see citing works

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

Girardin, S. E., Boneca, I. G., Viala, J., Chamaillard, M., Labigne-Roussel, A., Thomas, G. D., Philpott, D. J., & Sansonetti, P. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200651200 · Cited by 2,397 · see citing works

Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., & Flavell, R. A. (2005) · Science · doi:10.1126/science.1104911 · Cited by 1,776 · see citing works

Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Kleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A. B., Ifrim, D. C., Saeed, S., Jacobs, C., van Loenhout, J., de Jong, D., Stunnenberg, H. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202870109 · Cited by 1,728 · see citing works

Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

Inohara, N., Ogura, Y., Fontalba, A., Gutierrez, O., Pons, F., Crespo, J., Fukase, K., Inamura, S., Kusumoto, S., Hashimoto, M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200673200 · Cited by 1,694 · see citing works

Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

Girardin, S. E., Boneca, I. G., Carneiro, L. A. M., Antignac, A., Jéhanno, M., Viala, J., Tedin, K., Taha, M., Labigne-Roussel, A., Zäthringer, U., et al. (2003) · Science · doi:10.1126/science.1084677 · Cited by 1,574 · see citing works

Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB

Ogura, Y., Inohara, N., Benito, A., Chen, F. F., Yamaoka, S., & Núñez, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008072200 · Cited by 1,357 · see citing works

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

Chamaillard, M., Hashimoto, M., Horie, Y., Masumoto, J., Qiu, S., Saab, L., Ogura, Y., Kawasaki, A., Fukase, K., Kusumoto, S., et al. (2003) · Nature Immunology · doi:10.1038/ni945 · Cited by 1,323 · see citing works

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

Travassos, L. H., Carneiro, L. A. M., Ramjeet, M., Hussey, S., Kim, Y.-G., Magalhães, J. G., Yuan, L., Soares, F., Chea, E., Le Bourhis, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1823 · Cited by 1,306 · see citing works

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

Viala, J., Chaput, C., Boneca, I. G., Cardona, A., Girardin, S. E., Moran, A. P., Athman, R., Mémet, S., Huerre, M., Coyle, A. J., et al. (2004) · Nature Immunology · doi:10.1038/ni1131 · Cited by 1,221 · see citing works

The gut microbiota in IBD

Manichanh, C., Borruel, N., Casellas, F., & Guarner, F. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.152 · Cited by 1,160 · see citing works

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

Clarke, T. B., Davis, K. M., Lysenko, E. S., Zhou, A. Y., Yu, Y., & Weiser, J. N. (2010) · Nature Medicine · doi:10.1038/nm.2087 · Cited by 1,154 · see citing works

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

Bouskra, D., Brézillon, C., Bérard, M., Werts, C., Varona, R., Boneca, I. G., & Eberl, G. (2008) · Nature · doi:10.1038/nature07450 · Cited by 1,107 · see citing works

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

Fujita, N., Itoh, T., Omori, H., Fukuda, M., Noda, T., & Yoshimori, T. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1257 · Cited by 1,083 · see citing works

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

Cooney, R. M., BAKER, J. T., Brain, O., Danis, B., Pichulik, T., Allan, P., Ferguson, D. J. P., Campbell, B. J., Jewell, D. P., & Simmons, A. (2009) · Nature Medicine · doi:10.1038/nm.2069 · Cited by 1,046 · see citing works

CARD15 mutations in Blau syndrome

Miceli‐Richard, C., Lesage, S., Rybojad, M., Prieur, A., Manouvrier‐Hanu, S., Häfner, R., Chamaillard, M., Zouali, H., Thomas, G. D., & Hugot, J. (2001) · Nature Genetics · doi:10.1038/ng720 · Cited by 966 · see citing works

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

Cadwell, K., Patel, K., Maloney, N. S., Liu, T., Ng, A., Storer, C. E., Head, R. D., Xavier, R. J., Stappenbeck, T. S., & Virgin, H. W. (2010) · Cell · doi:10.1016/j.cell.2010.05.009 · Cited by 897 · see citing works

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

Amar, J., Chabo, C., Waget, A., Klopp, P., Vachoux, C., Bermúdez‐Humarán, L. G., Smirnova, N. F., Bergé, M., Sulpice, T., Lahtinen, S. J., et al. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100159 · Cited by 837 · see citing works

Escape of Intracellular Shigella from Autophagy

Ogawa, M., Yoshimori, T., Suzuki, T., Sagara, H., Mizushima, N., & Sasakawa, C. (2004) · Science · doi:10.1126/science.1106036 · Cited by 830 · see citing works

NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression

Wehkamp, J., Harder, J., Weichenthal, M., Schwab, M. G., Schäffeler, E., Schlee, M., Herrlinger, K. R., Stallmach, A., Noack, F., Fritz, P., et al. (2004) · Gut · doi:10.1136/gut.2003.032805 · Cited by 823 · see citing works

Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

Zigmond, E., Varol, C., Farache, J., Elmaliah, E., Satpathy, A. T., Friedlander, G., Mack, M., Shpigel, N. Y., Boneca, I. G., MURPHY, K. M. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.026 · Cited by 742 · see citing works

Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

Inohara, N., Koseki, T., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.14560 · Cited by 742 · see citing works

Peptidoglycan Molecular Requirements Allowing Detection by Nod1 and Nod2

Girardin, S. E., Travassos, L. H., Hervé, M., Blanot, D., Boneca, I. G., Philpott, D. J., Sansonetti, P. J., & Mengin‐Lecreulx, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307198200 · Cited by 684 · see citing works

Autophagy Controls Salmonella Infection in Response to Damage to the Salmonella-containing Vacuole

Birmingham, C. L., Smith, A. C., Bakowski, M. A., Yoshimori, T., & Brumell, J. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509157200 · Cited by 658 · see citing works

CARD4/Nod1 mediates NF‐κB and JNK activation by invasive Shigella flexneri

Girardin, S. E., Tournebize, R., Mavris, M., Page, A., Li, X., Stark, G. R., Bertin, J., DiStefano, P. S., Yaniv, M., Sansonetti, P. J., et al. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve155 · Cited by 608 · see citing works

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer

Couturier-Maillard, A., Sécher, T., Rehman, A., Normand, S., Arcangelis, A. D., Häsler, R., Huot, L., Grandjean, T., Bressenot, A., Delanoye, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62236 · Cited by 571 · see citing works

Nod2 is required for the regulation of commensal microbiota in the intestine

Petnicki-Ocwieja, T., Hrncir, T., Liu, Y.-J., Biswas, A., Hudcovic, T., Tlaskalova-Hogenova, H., & Kobayashi, K. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907722106 · Cited by 564 · see citing works

Modulating immunity as a therapy for bacterial infections

Hancock, R. E. W., Nijnik, A., & Philpott, D. J. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2745 · Cited by 542 · see citing works

An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways

Inohara, N., Koseki, T., Lin, J., del Peso, L., Lucas, P. C., Chen, F. F., Ogura, Y., & Núñez, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003415200 · Cited by 538 · see citing works

RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs

Park, J., Kim, Y., McDonald, C., Kanneganti, T., Hasegawa, M., Body–Malapel, M., Inohara, N., & Núñez, G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2380 · Cited by 532 · see citing works

A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation

Hasegawa, M., Fujimoto, Y., Lucas, P. C., Nakano, H., Fukase, K., Núñez, G., & Inohara, N. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601962 · Cited by 520 · see citing works

Stimulation of the Intracellular Bacterial Sensor NOD2 Programs Dendritic Cells to Promote Interleukin-17 Production in Human Memory T Cells

van Beelen, A. J., Zelinková, Z., Taanman-Kueter, E. W., Muller, F. J. M., Hommes, D. W., Zaat, S. A. J., Kapsenberg, M. L., & de Jong, E. C. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.013 · Cited by 516 · see citing works

Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor- B activation: common genetic etiology with Blau syndrome

Kanazawa, N. (2004) · Blood · doi:10.1182/blood-2004-07-2972 · Cited by 487 · see citing works

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

Kaparakis‐Liaskos, M., Turnbull, L., Carneiro, L. A. M., Firth, S. D., Coleman, H. A., Parkington, H. C., Bourhis, L. L., Karrar, A., Viala, J., Mak, J., et al. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01404.x · Cited by 455 · see citing works

Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

Gutiérrez, O., Pipaón, C., Inohara, N., Fontalba, A., Ogura, Y., Prósper, F., Núñez, G., & Fernández-Luna, J. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206473200 · Cited by 441 · see citing works

Expression of NOD2 in Paneth cells: a possible link to Crohn’s ileitis

Ogura, Y., Lala, S. G., Xin, W., Smith, E., Dowds, T. A., Chen, F. F., Zimmermann, E., Tretiakova, M., Cho, J. H., Hart, J., et al. (2003) · Gut · doi:10.1136/gut.52.11.1591 · Cited by 439 · see citing works

TNF-α and IFN-γ regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells

Rosenstiel, P. C., Fantini, M. C., Bräutigam, K., Waetzig, G., Kuehbacher, T., Seegert, D., & Schreiber, S. (2003) · Gastroenterology · doi:10.1053/gast.2003.50157 · Cited by 423 · see citing works

The Nod-Like Receptor (NLR) Family: A Tale of Similarities and Differences

Proell, M., Riedl, S. J., Fritz, J. H., Rojas, A. M., & Schwarzenbacher, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002119 · Cited by 403 · see citing works

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

Chin, A. I., Dempsey, P. W., Bruhn, K. W., Miller, J. F., Xu, Y., & Cheng, G. (2002) · Nature · doi:10.1038/416190a · Cited by 402 · see citing works

Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease

Wang, T. T., Dabbas, B., Laperrière, D., Bitton, A. J., Soualhine, H., Tavera-Mendoza, L. E., Dionne, S., Servant, M. J., Bitton, A., Seidman, E. G., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c109.071225 · Cited by 389 · see citing works

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

Lupfer, C., Thomas, P. G., Anand, P. K., Vogel, P., Milasta, S., Martinez, J., Huang, G., Green, M., Kundu, M., Chi, H., et al. (2013) · Nature Immunology · doi:10.1038/ni.2563 · Cited by 384 · see citing works

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W.-L., Fiil, B. K., Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.014 · Cited by 379 · see citing works

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system

Boneca, I. G., Dussurget, O., Cabanes, D., Nahori, M., Sousa, S., Lecuit, M., Psylinakis, E., Bouriotis, V., Hugot, J., Giovannini, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609672104 · Cited by 378 · see citing works

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

Fernandez, E. M., Valenti, V., Rockel, C., Hermann, C., Pot, B., Boneca, I. G., & Grangette, C. (2011) · Gut · doi:10.1136/gut.2010.232918 · Cited by 376 · see citing works

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

Homer, C. R., Richmond, A. L., Rebert, N. A., Achkar, J., & McDonald, C. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.07.006 · Cited by 373 · see citing works

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

Tanabe, T., Chamaillard, M., Ogura, Y., Li, Z., Qiu, S., Masumoto, J., Ghosh, P., Moran, A. P., Predergast, M. M., Tromp, G. C., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600175 · Cited by 362 · see citing works

Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists

Fritz, J. H., Girardin, S. E., Fitting, C., Werts, C., Mengin‐Lecreulx, D., Caroff, M., Cavaillon, J., Philpott, D. J., & Adib‐Conquy, M. (2005) · European Journal of Immunology · doi:10.1002/eji.200526286 · Cited by 355 · see citing works

The Ubiquitin-Editing Enzyme A20 Restricts Nucleotide-Binding Oligomerization Domain Containing 2-Triggered Signals

Hitotsumatsu, O., Ahmad, R., Tavares, R. M., Wang, M., Philpott, D. J., Turer, E. E., Lee, B. L., Shiffin, N., Advincula, R., Malynn, B. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.002 · Cited by 349 · see citing works

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

Bertrand, M. J. M., Doiron, K., Labbè, K., Korneluk, R. G., Barker, P. A., & Saleh, M. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.011 · Cited by 338 · see citing works

Nod1-Mediated Innate Immune Recognition of Peptidoglycan Contributes to the Onset of Adaptive Immunity

Fritz, J. H., Bourhis, L. L., Sellge, G., Magalhaes, J. G., Fsihi, H., Kufer, T. A., Collins, C., Viala, J., Ferrero, R. L., Girardin, S. E., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.009 · Cited by 331 · see citing works

Nod2 is essential for temporal development of intestinal microbial communities

Rehman, A., Sina, C., Gavrilova, O., Häsler, R., Ott, S. J., Baines, J. F., Schreiber, S., & Rosenstiel, P. C. (2011) · Gut · doi:10.1136/gut.2010.216259 · Cited by 316 · see citing works

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

van Heel, D. A., Ghosh, S. K., Butler, M., Hunt, K. A., Lundberg, A. M., Ahmad, T., McGovern, D. P. B., Onnie, C. M., Negoro, K., Goldthorpe, S., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66582-8 · Cited by 312 · see citing works

Gene–environment interaction modulated by allelic heterogeneity in inflammatory diseases

Chamaillard, M., Philpott, D. J., Girardin, S. E., Zouali, H., Lesage, S., Chareyre, F., Bui, T. H., Giovannini, M., Zaehringer, U., Penard‐Lacronique, V., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530276100 · Cited by 310 · see citing works

Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice

Ubeda, C., Lipuma, L., Gobourne, A., Viale, A., Leiner, I., Equinda, M., Khanin, R., & Pamer, E. G. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120504 · Cited by 310 · see citing works

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor–κB activation in muramyl dipeptide recognition

Barnich, N., Aguirre, J. E., Reinecker, H., Xavier, R. J., & Podolsky, D. K. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502153 · Cited by 289 · see citing works

XIAP mediates NOD signaling via interaction with RIP2

Krieg, A. H., Correa, R. G., Garrison, J. B., Negrate, G. L., Welsh, K., Huang, Z., Knoefel, W. T., & Reed, J. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907131106 · Cited by 287 · see citing works

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

Kim, Y., Park, J., Shaw, M. H., Franchi, L., Inohara, N., & Núñez, G. (2008) · Immunity · doi:10.1016/j.immuni.2007.12.012 · Cited by 280 · see citing works

Nucleotide-Binding Oligomerization Domain-2 Modulates Specific TLR Pathways for the Induction of Cytokine Release

Netea, M. G., Ferwerda, G., de Jong, D. J., Jansen, T., Jacobs, L., Kramer, M., Naber, A. H. J., Drenth, J. P. H., Girardin, S. E., Kullberg, B. J., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6518 · Cited by 274 · see citing works

Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation

Holler, E., Rogler, G., Herfarth, H. H., Brenmoehl, J., Wild, P. J., Hahn, J. R., Eißner, G., Schölmerich, J., & Andreesen, R. (2004) · Blood · doi:10.1182/blood-2003-10-3543 · Cited by 272 · see citing works

Crohn disease–associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae

Chassaing, B., Rolhion, N., de Vallée, A., Salim, S. Y., Prorok-Hamon, M., Neut, C., Campbell, B. J., Söderholm, J. D., Hugot, J., Colombel, J., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44632 · Cited by 267 · see citing works

NOD1 variation, immunoglobulin E and asthma

Hysi, P. G., Kabesch, M., Moffatt, M. F., Schedel, M., Carr, D., Zhang, Y., Boardman, B., von Mutius, E., Weiland, S. K., Leupold, W., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi087 · Cited by 266 · see citing works

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

Watanabe, T., Asano, N., Fichtner‐Feigl, S., Gorelick, P. L., Tsuji, Y., Matsumoto, Y. M., Chiba, T., Fuss, I. J., Kitani, A., & Strober, W. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39481 · Cited by 265 · see citing works

The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis

Chen, G. Y., Shaw, M. H., Redondo, G., & Núñez, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2061 · Cited by 261 · see citing works

<i>Listeria monocytogenes</i>Evades Killing by Autophagy During Colonization of Host Cells

Birmingham, C. L., Canadien, V., Gouin, E., Troy, E. B., Yoshimori, T., Cossart, P., Higgins, D. E., & Brumell, J. H. (2007) · Autophagy · doi:10.4161/auto.4450 · Cited by 254 · see citing works

NOD1 activators link innate immunity to insulin resistance

Schertzer, J. D., Tamrakar, A. K., Magalhães, J. G., Pereira, S., Bilan, P. J., Fullerton, M. D., Liu, Z., Steinberg, G. R., Giacca, A., Philpott, D. J., et al. (2011) · Diabetes · doi:10.2337/db11-0004 · Cited by 253 · see citing works

Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans

Raju, D., Hussey, S., Ang, M., Terebiznik, M. R., Sibony, M., Galindo‐Mata, E., Gupta, V. R., Blanke, S. R., Delgado, A., Romero–Gallo, J., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.01.043 · Cited by 245 · see citing works

hPepT1 transports muramyl dipeptide, activating NF-κB and stimulating IL-8 secretion in human colonic Caco2/bbe cells

Vavricka, S. R., Musch, M. W., Chang, J. E., Nakagawa, Y., Phanvijhitsiri, K., Waypa, T. S., Merlin, D., Schneewind, O., & Chang, E. B. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.07.024 · Cited by 243 · see citing works

Reduced α-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn’s disease

Simms, L. A., Doecke, J. D., Walsh, M., Huang, N., Fowler, E. V., & Radford‐Smith, G. L. (2008) · Gut · doi:10.1136/gut.2007.142588 · Cited by 243 · see citing works

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

Kim, Y., Kamada, N., Shaw, M. H., Warner, N. E., Chen, G., Franchi, L., & Núñez, G. (2011) · Immunity · doi:10.1016/j.immuni.2011.04.013 · Cited by 242 · see citing works

Identification of an innate T helper type 17 response to intestinal bacterial pathogens

Geddes, K., Rubino, S. J., Magalhaes, J. G., Streutker, C., Bourhis, L. L., Cho, J., Robertson, S. J., Kim, C. J., Kaul, R., Philpott, D. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2391 · Cited by 235 · see citing works

Unleashing the therapeutic potential of NOD-like receptors

Geddes, K., Magalhaes, J. G., & Girardin, S. E. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2783 · Cited by 233 · see citing works

NOD2 Pathway Activation by MDP or Mycobacterium tuberculosis Infection Involves the Stable Polyubiquitination of Rip2

Yang, Y., Yin, C., Pandey, A. K., Abbott, D. W., Sassetti, C. M., & Kelliher, M. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703079200 · Cited by 228 · see citing works

Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1

Keestra, A. M., Winter, M. G., Auburger, J. J., Fräßle, S. P., Byndloss, M. X., Winter, S., Kim, A., Poon, V., Ravesloot-Chávez, M. M., Waldenmaier, J. F. T., et al. (2013) · Nature · doi:10.1038/nature12025 · Cited by 224 · see citing works

pH-dependent Internalization of Muramyl Peptides from Early Endosomes Enables Nod1 and Nod2 Signaling

Lee, J., Tattoli, I., Wojtal, K. A., Vavricka, S. R., Philpott, D. J., & Girardin, S. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.033670 · Cited by 214 · see citing works

NOD2 contributes to cutaneous defense against Staphylococcus aureus through α-toxin-dependent innate immune activation

Hruz, P., Zinkernagel, A., Jenikova, G., Botwin, G. J., Hugot, J., Karin, M., Nizet, V., & Eckmann, L. (2009) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0904958106 · Cited by 214 · see citing works

The Intracellular Sensor NOD2 Induces MicroRNA-29 Expression in Human Dendritic Cells to Limit IL-23 Release

Brain, O., Owens, B. M. J., Pichulik, T., Allan, P., Khatamzas, E., Leslie, A. J., Steevels, T. A. M., Sharma, S., Mayer, A., Catuneanu, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.035 · Cited by 201 · see citing works

A Crohn's disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1

Noguchi, E., Homma, Y., Kang, X., Netea, M. G., & Ma, X. (2009) · Nature Immunology · doi:10.1038/ni.1722 · Cited by 200 · see citing works

The Protein ATG16L1 Suppresses Inflammatory Cytokines Induced by the Intracellular Sensors Nod1 and Nod2 in an Autophagy-Independent Manner

Sorbara, M. T., Ellison, L. K., Ramjeet, M., Travassos, L. H., Jones, N. L., Girardin, S. E., & Philpott, D. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.013 · Cited by 198 · see citing works

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responsesPreprint

Tigno-Aranjuez, J. T., Asara, J. M., & Abbott, D. W. (2010) · Genes & Development · doi:10.1101/gad.1964410 · Cited by 194 · see citing works

The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment

Grimes, C. L., Ariyananda, L. D. Z., Melnyk, J. E., & O’Shea, E. K. (2012) · Journal of the American Chemical Society · doi:10.1021/ja303883c · Cited by 194 · see citing works

Association of NOD1 polymorphisms with atopic eczema and related phenotypes

Weidinger, S., Klopp, N., Rummler, L., Wagenpfeil, S., Novak, N., Baurecht, H., Groer, W., Darsow, U., Heinrich, J., Gauger, A., et al. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.034 · Cited by 190 · see citing works

Nod2-Dependent Th2 Polarization of Antigen-Specific Immunity

Magalhaes, J. G., Fritz, J. H., Bourhis, L. L., Sellge, G., Travassos, L. H., Selvanantham, T., Girardin, S. E., Gommerman, J. L., & Philpott, D. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.11.7925 · Cited by 188 · see citing works

T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii

Shaw, M. H., Reimer, T., Sánchez-Valdepeñas, C., Warner, N. E., Kim, Y., Fresno, M., & Núñez, G. (2009) · Nature Immunology · doi:10.1038/ni.1816 · Cited by 179 · see citing works

A Role for Erbin in the Regulation of Nod2-dependent NF-κB Signaling

McDonald, C., Chen, F. F., Ollendorff, V., Ogura, Y., Marchetto, S., Lécine, P., Borg, J., & Núñez, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508538200 · Cited by 178 · see citing works

Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin

Magalhaes, J. G., Philpott, D. J., Nahori, M., Jéhanno, M., Fritz, J., Bourhis, L. L., Viala, J., Hugot, J., Giovannini, M., Bertin, J., et al. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400552 · Cited by 177 · see citing works

Differential Release and Distribution of Nod1 and Nod2 Immunostimulatory Molecules among Bacterial Species and Environments

Hasegawa, M., Yang, K., Hashimoto, M., Park, J., Kim, Y., Fujimoto, Y., Núñez, G., Fukase, K., & Inohara, N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602638200 · Cited by 175 · see citing works

Pathogen Sensing by Nucleotide-binding Oligomerization Domain-containing Protein 2 (NOD2) Is Mediated by Direct Binding to Muramyl Dipeptide and ATP

Mo, J., Boyle, J. P., Howard, C. B., Monie, T. P., Davis, B. K., & Duncan, J. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.344283 · Cited by 168 · see citing works

Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum

Biswas, A., Liu, Y.-J., Hao, L., Mizoguchi, A., Salzman, N. H., Bevins, C. L., & Kobayashi, K. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003363107 · Cited by 166 · see citing works

Role for Erbin in Bacterial Activation of Nod2

Kufer, T. A., Kremmer, E., BANKS, D. J., & Philpott, D. J. (2006) · Infection and Immunity · doi:10.1128/iai.00035-06 · Cited by 150 · see citing works

Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes

Jiang, W., Wang, X., Zeng, B., Liu, L., Tardivel, A., Wei, H., Han, J., MacDonald, H. R., Tschopp, J., Tian, Z., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122490 · Cited by 148 · see citing works

Signaling via the RIP2 Adaptor Protein in Central Nervous System-Infiltrating Dendritic Cells Promotes Inflammation and Autoimmunity

Shaw, P. J., Barr, M., Lukens, J. R., McGargill, M. A., Chi, H., Mak, T. W., & Kanneganti, T. (2011) · Immunity · doi:10.1016/j.immuni.2010.12.015 · Cited by 147 · see citing works

Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis

Robertson, S. J., Zhou, J. Y., Geddes, K., Rubino, S. J., Cho, J., Girardin, S. E., & Philpott, D. J. (2013) · Gut Microbes · doi:10.4161/gmic.24373 · Cited by 147 · see citing works

Blau syndrome, clinical and genetic aspects

Sfriso, P., Caso, F., Tognon, S., Galozzi, P., Gava, A., & Punzi, L. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.07.028 · Cited by 147 · see citing works

Multiple Peptidoglycan Modification Networks Modulate Helicobacter pylori's Cell Shape, Motility, and Colonization Potential

Sycuro, L. K., Wyckoff, T. J. O., Biboy, J., Born, P., Pincus, Z., Vollmer, W., & Salama, N. R. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002603 · Cited by 146 · see citing works

ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways

Tao, M., Scacheri, P. C., Marinis, J. M., Harhaj, E. W., Matesic, L. E., & Abbott, D. W. (2009) · Current Biology · doi:10.1016/j.cub.2009.06.038 · Cited by 141 · see citing works

TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation

Anand, P., Tait, S. W. G., Lamkanfi, M., Amer, A. O., Núñez, G., Pagès, G., Pouysségur, J., McGargill, M. A., Green, D. R., & Kanneganti, T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.310599 · Cited by 140 · see citing works

Commensal and Probiotic Bacteria Influence Intestinal Barrier Function and Susceptibility to Colitis in Nod1−/−;Nod2−/− Mice

Natividad, J. M. M., Petit, V., Huang, X., de Palma, G., Jury, J., Sanz, Y., Philpott, D., Garcia Rodenas, C. L., McCoy, K. D., & Verdu, E. F. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22848 · Cited by 139 · see citing works

Peptidoglycan: a critical activator of the mammalian immune system during infection and homeostasis

Sorbara, M. T., & Philpott, D. J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01047.x · Cited by 136 · see citing works

Clathrin- and Dynamin-Dependent Endocytic Pathway Regulates Muramyl Dipeptide Internalization and NOD2 Activation

Marina–García, N., Franchi, L., Kim, Y., Hu, Y., Smith, D. E., Boons, G., & Núñez, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802197 · Cited by 133 · see citing works

Yersinia pseudotuberculosis Effector YopJ Subverts the Nod2/RICK/TAK1 Pathway and Activates Caspase-1 to Induce Intestinal Barrier Dysfunction

Meinzer, U., Barreau, F., Esmiol-Welterlin, S., Jung, C., Villard, C., Léger, T., Mkaddem, S. B., Berrebi, D. D., Dussaillant, M., Nabhani, Z. A., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.02.009 · Cited by 132 · see citing works

Identification of the Critical Residues Involved in Peptidoglycan Detection by Nod1

Girardin, S. E., Jéhanno, M., Mengin‐Lecreulx, D., Sansonetti, P. J., Alzari, P. M., & Philpott, D. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509537200 · Cited by 128 · see citing works

Influence of polymorphisms in the NOD1/CARD4 and NOD2/CARD15 genes on the clinical outcome of Helicobacter pylori infection

Rosenstiel, P. C., Hellmig, S., Hampe, J., Ott, S., Till, A., Fischbach, W., Sahly, H., Lucius, R., Fölsch, U. R., Philpott, D. J., et al. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00701.x · Cited by 124 · see citing works

Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands

Magalhaes, J. G., Lee, J., Geddes, K., Rubino, S. J., Philpott, D. J., & Girardin, S. E. (2011) · European Journal of Immunology · doi:10.1002/eji.201040827 · Cited by 123 · see citing works

Non-apoptotic role of BID in inflammation and innate immunity

Yeretssian, G., Correa, R. G., Doiron, K., Fitzgerald, P., Dillon, C. P., Green, D. R., Reed, J. C., & Saleh, M. (2011) · Nature · doi:10.1038/nature09982 · Cited by 122 · see citing works

Nod1 and Nod2 Regulation of Inflammation in the Salmonella Colitis Model

Geddes, K., Rubino, S. J., Streutker, C., Cho, J. H., Magalhaes, J. G., Bourhis, L. L., Selvanantham, T., Girardin, S. E., & Philpott, D. J. (2010) · Infection and Immunity · doi:10.1128/iai.00759-10 · Cited by 121 · see citing works

Cell-Cell Propagation of NF-κB Transcription Factor and MAP Kinase Activation Amplifies Innate Immunity against Bacterial Infection

Kasper, C. A., Sorg, I., Schmutz, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.015 · Cited by 118 · see citing works

Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes

Jiang, W., Wang, X., Zeng, B., Liu, L., Tardivel, A., Wei, H., Han, J., MacDonald, H. R., Tschopp, J., Tian, Z., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.2012249011042013c · Cited by 115 · see citing works

TRIM27 Negatively Regulates NOD2 by Ubiquitination and Proteasomal Degradation

Zurek, B., Schoultz, I., Neerincx, A., Napolitano, L. M. R., Birkner, K., Bennek, E., Sellge, G., Lerm, M., Meroni, G., Söderholm, J. D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041255 · Cited by 115 · see citing works

A Deficiency in the Autophagy Gene Atg16L1 Enhances Resistance to Enteric Bacterial Infection

Marchiando, A. M., Ramanan, D., Ding, Y., Gomez, L. E., Hubbard-Lucey, V. M., Maurer, K., Wang, C., Ziel, J. W., van Rooijen, N., Núñez, G., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.013 · Cited by 114 · see citing works

Viral Infection Augments Nod1/2 Signaling to Potentiate Lethality Associated with Secondary Bacterial Infections

Kim, Y., Park, J., Reimer, T., Baker, D. P., Kawai, T., Kumar, H., Akira, S., Wobus, C. E., & Núñez, G. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.05.006 · Cited by 113 · see citing works

GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors

Fukazawa, A., Alonso, C., Kurachi, K., Gupta, S., Lesser, C. F., McCormick, B. A., & Reinecker, H. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000228 · Cited by 110 · see citing works

Modulation of Nod2-dependent NF-κB signaling by the actin cytoskeleton

Legrand-Poels, S., Kustermans, G., Bex, F., Kremmer, E., Kufer, T., & Piette, J. (2007) · Journal of Cell Science · doi:10.1242/jcs.03424 · Cited by 110 · see citing works

NOD2 regulates hematopoietic cell function during graft-versus-host disease

Penack, O., Smith, O. M., Cunningham‐Bussel, A., Liu, X., Rao, U. K., Yim, N. L., Na, I., Holland, A. M., Ghosh, A., Lu, S. X., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090623 · Cited by 109 · see citing works

Mouse Paneth cell antimicrobial function is independent of Nod2

Shanahan, M. T., Carroll, I. M., Grossniklaus, E. J., White, A., von Furstenberg, R. J., Barner, R., Fodor, A. A., Henning, S., Sartor, R. B., & Gulati, A. (2013) · Gut · doi:10.1136/gutjnl-2012-304190 · Cited by 105 · see citing works

PGLYRP-2 and Nod2 Are Both Required for Peptidoglycan-Induced Arthritis and Local Inflammation

Saha, S., Qi, J., Wang, S., Wang, M. H., Li, X., Kim, Y., Núñez, G., Gupta, D., & Dziarski, R. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2008.12.010 · Cited by 104 · see citing works

Sensing of Commensal Organisms by the Intracellular Sensor NOD1 Mediates Experimental Pancreatitis

Tsuji, Y., Watanabe, T., Kudo, M., Arai, H., Strober, W., & Chiba, T. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.024 · Cited by 101 · see citing works

Peptidoglycan-Modifying Enzyme Pgp1 Is Required for Helical Cell Shape and Pathogenicity Traits in Campylobacter jejuni

Frirdich, E., Biboy, J., Adams, C. B., Lee, J., Ellermeier, J. R., Gielda, L. M., DiRita, V. J., Girardin, S. E., Vollmer, W., & Gaynor, E. C. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002602 · Cited by 99 · see citing works

Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo

Wang, C., Mendonsa, G. R., Symington, J., Zhang, Q., Cadwell, K., Virgin, H. W., & Mysorekar, I. U. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203952109 · Cited by 97 · see citing works

l-Ala-γ-d-Glu-meso-diaminopimelic Acid (DAP) Interacts Directly with Leucine-rich Region Domain of Nucleotide-binding Oligomerization Domain 1, Increasing Phosphorylation Activity of Receptor-interacting Serine/Threonine-protein Kinase 2 and Its Interaction with Nucleotide-binding Oligomerization Domain 1

Laroui, H., Yan, Y., Narui, Y., Ingersoll, S. A., Ayyadurai, S., Charania, M. A., Zhou, F., Wang, B., Salaita, K. S., Sitaraman, S. V., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.257501 · Cited by 97 · see citing works

The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila

Frutuoso, M. S., Hori, J. I., Pereira, M. S. F., Lima-Junior, D. S., Sônego, F., Kobayashi, K. S., Flavell, R. A., Cunha, F. Q., & Zamboni, D. S. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.05.006 · Cited by 97 · see citing works

Nod-like receptors in the control of intestinal inflammation

Rubino, S. J., Selvanantham, T., Girardin, S. E., & Philpott, D. J. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.04.010 · Cited by 94 · see citing works

Altered gut microbiota composition in immune-impaired Nod2 −/− mice

Mondot, S., Barreau, F., Nabhani, Z. A., Dussaillant, M., Roux, K. L., Dore, J. M., Leclerc, M., Hugot, J., & Lepage, P. (2011) · Gut · doi:10.1136/gutjnl-2011-300478 · Cited by 94 · see citing works

The intermediate filament protein, vimentin, is a regulator of NOD2 activity

Stevens, C., Henderson, P., Nimmo, E. R., Soares, D. C., Dogan, B., Simpson, K. W., Barrett, J. C., Wilson, D. C., & Satsangi, J. J. (2012) · Gut · doi:10.1136/gutjnl-2011-301775 · Cited by 94 · see citing works

Nucleotide-binding oligomerization domain containing 2: Structure, function, and diseases

Yao, Q. (2013) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2012.12.005 · Cited by 94 · see citing works

Innate signals from Nod2 block respiratory tolerance and program TH2-driven allergic inflammation

Duan, W., Mehta, A. K., Magalhaes, J. G., Ziegler, S. F., Dong, C., Philpott, D. J., & Croft, M. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.021 · Cited by 94 · see citing works

Proteasomal Degradation of Nod2 Protein Mediates Tolerance to Bacterial Cell Wall Components

Lee, K., Biswas, A., Liu, Y.-J., & Kobayashi, K. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.410027 · Cited by 93 · see citing works

Nod-like receptors: sentinels at host membranes

Philpott, D. J., & Girardin, S. E. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.04.010 · Cited by 89 · see citing works

NOD-Like Receptor Activation by Outer Membrane Vesicles from Vibrio cholerae Non-O1 Non-O139 Strains Is Modulated by the Quorum-Sensing Regulator HapR

Bielig, H., Rompikuntal, P. K., Dongre, M., Zurek, B., Lindmark, B., Ramstedt, M., Wai, S. N., & Kufer, T. A. (2011) · Infection and Immunity · doi:10.1128/iai.00754-10 · Cited by 89 · see citing works

A Dual Role for Receptor-interacting Protein Kinase 2 (RIP2) Kinase Activity in Nucleotide-binding Oligomerization Domain 2 (NOD2)-dependent Autophagy

Homer, C. R., Kabi, A., Marina–García, N., Sreekumar, A., Nesvizhskii, A. I., Nickerson, K. P., Chinnaiyan, A. M., Núñez, G., & McDonald, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.326835 · Cited by 89 · see citing works

Up-Regulation of NOD1 and NOD2 through TLR4 and TNF-.ALPHA. in LPS-treated Murine Macrophages

Takahashi, Y., ISUZUGAWA, K., Murase, Y., Imai, M., Yamamoto, S., Iizuka, M., Akira, S., Bahr, G. M., Momotani, E., Hori, M., et al. (2006) · Journal of Veterinary Medical Science · doi:10.1292/jvms.68.471 · Cited by 87 · see citing works

Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation

Magalhaes, J. G., Rubino, S. J., Travassos, L. H., Bourhis, L. L., Duan, W., Sellge, G., Geddes, K., Reardon, C., Lechmann, M., Carneiro, L. A. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015063108 · Cited by 83 · see citing works

A new CARD15 mutation in Blau syndrome

van Duist, M. M., Albrecht, M., Podswiadek, M., et al. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201404 · Cited by 78 · see citing works

Mutational analysis of human NOD1 and NOD2 NACHT domains reveals different modes of activation

Zurek, B., Proell, M., Wagner, R. N., Schwarzenbacher, R., & Kufer, T. A. (2011) · Innate Immunity · doi:10.1177/1753425910394002 · Cited by 77 · see citing works

A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of the NOD2 and NF-κB Signaling Pathways

Warner, N. E., Burberry, A., Franchi, L., Kim, Y., McDonald, C., Sartor, M. A., & Núñez, G. (2013) · Science Signaling · doi:10.1126/scisignal.2003305 · Cited by 68 · see citing works

RNAi screening identifies mediators of NOD2 signaling: Implications for spatial specificity of MDP recognition

Lipinski, S., Grabe, N., Jacobs, G., Billmann-Born, S., Till, A., Häsler, R., Aden, K., Paulsen, M., Arlt, A., Kraemer, L., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209673109 · Cited by 68 · see citing works

Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis

Joosten, L. A. B., Heinhuis, B., Abdollahi‐Roodsaz, S., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710445105 · Cited by 67 · see citing works

β-PIX and Rac1 GTPase Mediate Trafficking and Negative Regulation of NOD2

Eitel, J., Krüll, M., Hocke, A. C., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2664 · Cited by 65 · see citing works

Muramyl Dipeptide Induces NOD2-Dependent Ly6Chigh Monocyte Recruitment to the Lungs and Protects Against Influenza Virus Infection

Coulombe, F., Fiola, S., Akira, S., Cormier, Y. F., & Gosselin, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036734 · Cited by 64 · see citing works

Butyrate mediates nucleotide‐binding and oligomerisation domain (NOD) 2‐dependent mucosal immune responses against peptidoglycan

Leung, C., Lam, W. Y., Ma, D., Gullen, E. A., & Cheng, Y. (2009) · European Journal of Immunology · doi:10.1002/eji.200939454 · Cited by 56 · see citing works

Joint NOD2/RIPK2 Signaling Regulates IL-17 Axis and Contributes to the Development of Experimental Arthritis

Vieira, S. M., Cunha, T. M., França, R. F. D. O., Pinto, L. G., Talbot, J., Turato, W. M., Lemos, H. D. P., Lima, J. B., Verri, W. A., Jr., Almeida, S. C. L., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1004190 · Cited by 56 · see citing works

Cyclosporine A Impairs Nucleotide Binding Oligomerization Domain (Nod1)-Mediated Innate Antibacterial Renal Defenses in Mice and Human Transplant Recipients

Tourneur, E., Mkaddem, S. B., Chassin, C., Bens, M., Goujon, J., Charles, N., Pellefigues, C., Aloulou, M., Hertig, A., Monteiro, R. C., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003152 · Cited by 49 · see citing works

Cutting Edge: Primary Innate Immune Cells Respond Efficiently to Polymeric Peptidoglycan, but Not to Peptidoglycan Monomers

Iyer, J. K., & Coggeshall, K. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004058 · Cited by 48 · see citing works

Role of Nod1 in Mucosal Dendritic Cells during Salmonella Pathogenicity Island 1-Independent Salmonella enterica Serovar Typhimurium Infection

Bourhis, L. L., Magalhaes, J. G., Selvanantham, T., et al. (2009) · Infection and Immunity · doi:10.1128/iai.01067-09 · Cited by 48 · see citing works

Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer

Möckelmann, N., Schönfels, W. V., Buch, S., et al. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-79 · Cited by 45 · see citing works

Ubiquitin Regulates Caspase Recruitment Domain-mediated Signaling by Nucleotide-binding Oligomerization Domain-containing Proteins NOD1 and NOD2

Heul, A. V., Fowler, C. A., Ramaswamy, S., & Piper, R. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.413781 · Cited by 43 · see citing works

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