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Cited by 25Chronic Obstructive Pulmonary Disease (COPD) ResearchMuscle Physiology and DisordersNutrition and Health in Aging

Skeletal Myosteatosis Is Associated with Systemic Inflammation and a Loss of Muscle Bioenergetics in Stable COPD

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Persson, Hans Lennart, Sioutas, Apostolos, Kentson, Magnus, Jacobson, Petra, Lundberg, Peter, Dahlqvist Leinhard, Olof, Forsgren, Mikael Fredrik·2022·Journal of Inflammation Research
DOI 10.2147/jir.s366204PMC PMC9355337
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Abstract

Background: Common features among patients with more advanced chronic obstructive pulmonary disease (COPD) are systemic inflammation and a loss of both muscle mass and normal muscle composition. In the present study, we investigated COPD subjects to better understand how thigh muscle fat infiltration (MFI) and energy metabolism relate to each other and to clinical features of COPD with emphasis on systemic inflammation. Methods: Thirty-two Caucasians with stable COPD were investigated using questionnaires, lung function tests, blood analysis and magnetic resonance imaging (MRI) for analysis of body- and thigh muscle composition. Bioenergetics in the resting thigh muscle, expressed as the PCr/Pi ratio, were analysed using 31 phosphorus magnetic resonance spectroscopy ( 31 P-MRS). Results: Based on the combination of the MFI adjusted for sex (MFI a ) and the thigh fat-tissue free muscle volume, expressed as the deviation from the expected muscle volume of a matched virtual control group (FFMV vcg ), all COPD subjects displayed abnormally composed thigh muscles. Clinical features of increased COPD severity, including a decrease of blood oxygenation (r = − 0.44, p < 0.05) and FEV 1 /FVC ratio, reflecting airway obstruction (r = − 0.53, p < 0.01) and an increase of COPD symptoms (r = 0.37, p < 0.05) and breathing frequency at rest (r = 0.41, p < 0.05), were all associated with a raise of the PCr/Pi ratio in the thigh muscle. Increased MFI a of the thigh muscle correlated positively with markers of systemic inflammation (white blood cell count, r = 0.41, p < 0.05; fibrinogen, r = 0.44, p < 0.05), and negatively with weekly physical activity (r = − 0.40, p < 0.05) and the PCr/Pi ratio in the resting thigh muscle (r = − 0.41, p < 0.05). Conclusion: The present study implies a link between systemic inflammation, excessive MFI and a loss of bioenergetics in subjects with stable COPD. Keywords: adiposity, body composition, muscle fat infiltration, magnetic resonance imaging, 31 P-MRS, biomarkers

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  • Adipose tissue infiltration has been reported in COPD muscle, particularly in the obese sarcopenic phenotype where adipose inflammation leads to redistribution of fat to the intra-abdominal area and skeletal muscle tissue.

    “Adipose tissue infiltration has also been reported in COPD muscle, in a similar way to senescent muscle in the aging population, particularly in the obese sarcopenic phenotype where adipose inflammation leads to the redistribution of fat to the intra-abdominal area and skeletal muscle tissue [16,17]”

    From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [16]

    The Introduction defines muscle fat infiltration in COPD, and the Discussion reports excess thigh-muscle fat infiltration and visceral adipose tissue in the COPD cohort. The paper does not establish that infiltration occurs particularly in an obese sarcopenic phenotype or that adipose inflammation causes fat to redistribute into the abdomen and muscle. Instead, it describes those fat deposits as possible sources of systemic inflammation. (LLM, conf=0.88)

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Cited by

Sorted by citations

  • Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting

    Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076454 · Cited by 85 · see citing works

    “Adipose tissue infiltration has also been reported in COPD muscle, in a similar way to senescent muscle in the aging population, particularly in the obese sarcopenic phenotype where adipose inflammation leads to the redistribution of fat to the intra-abdominal area and skeletal muscle tissue [16,17] (Figure 1).”
    Background

Authors
Persson, H. L., Sioutas, A., Kentson, M., Jacobson, P., Lundberg, P., Dahlqvist Leinhard, O., & Forsgren, M. F.
Affiliations
Linköping University (SE)
Corresponding author
Persson, Hans Lennart
ORCID
Venue
Journal of Inflammation Research
Publisher
Informa UK Limited
Published
2022-08
Volume
Volume 15
Pages
4367-4384
ISSN
1178-7031 (ISSN-L)
DOI
10.2147/jir.s366204
PMC
PMC9355337
OpenAlex
W4289201586
Cited by
25
References
3
Citations by year
2026: 12 · 2025: 4 · 2024: 5 · 2023: 4
FWCI
2.10
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Inflammation Research (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders
  • Forskningsrådet i Sydöstra Sverige
  • Region Östergötland
  • Fondation pour la Recherche Médicale
  • Linköpings Universitet
  • Svenska Läkaresällskapet (SLS-368431)
  • Medical Research Council
  • Futurum - Akademin för Hälsa och Vård, Region Jönköpings läns
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
chronic obstructive pulmonary disease, muscle fat infiltration, systemic inflammation, muscle energy metabolism, phosphocreatine to inorganic phosphate ratio, fibrinogen, physical activity, body composition, adiposity

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