Quadriceps muscle fat infiltration is associated with cardiometabolic risk in COPD
Abstract
Summary: Purpose: Losses of peripheral muscle mass and ectopic fat accumulation have been associated with cardiometabolic morbidity in COPD . We aimed at identifying the relationship between quadriceps muscle fat infiltration and cardiovascular risk. Materials and methods: From 2009 to 2014, 78 COPD patients (64 ± 8 years; 80% male) were prospectively included after having given written consent (ethical committee approval number: 2006‐A00491‐50). The cohort was divided into three groups (tertiles) according to body mass index ( BMI ), low [15 < BMI ≤23·3], middle [23·3 < BMI ≤27·6] and high [27·6 < BMI ≤36] kg/m²). Measurements were respiratory function, plasmatic biomarkers and surrogate markers of cardiovascular risk (arterial stiffness and endothelial function). Mid‐thigh quadriceps muscle volume and per cent of muscle fat infiltration, as assessed by 64‐slice CT scanning, were compared between the tertiles. ANOVA or Kruskal–Wallis tests were used for statistical analyses with Bonferroni's correction for the ‘post hoc’ tests. Results: Intramuscular fat volume was 52% [95% CI , 43 to 60%] of total quadriceps volume in high BMI vs. 47% [38 to 55%] and 34% [29 to 38%] in the middle and low‐ BMI groups, respectively ( P <0·0001), without differences between groups in fat‐free muscle volumes. Elevated muscle fat infiltration correlated with lower thiol to protein ratios in the whole population reflecting impaired antioxidant capacity ( r = 0·50; P = 0·009). Furthermore, muscle fat infiltration was linked to endothelial dysfunction ( r = −0·49, P = 0·01) in the low‐ BMI group. Conclusion: Skeletal muscle fat infiltration may be an indicator of increased cardiometabolic risk in both obese and lean COPD patients.
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The redistribution of fat does not necessarily manifest as obesity, but intramuscular fat infiltration generally increases the chances of progression to obesity across adults.
“It is noteworthy that while the redistribution of fat does not necessarily manifest as obesity, intramuscular fat infiltration generally increases the chances of progression to obesity across adults.[ 11 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [11]
Clinical data showed that skeletal muscle fat infiltration occurred in both lean and obese individuals, although the infiltrated muscle volume was positively associated with body mass index (BMI).
“Clinical data showed that skeletal muscle fat infiltration occurred in both lean and obese individuals, although the infiltrated muscle volume was positively associated with body mass index (BMI).[ 11 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [11]
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Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review
Li, C., Yu, K., Shyh‐Chang, N., Jiang, Z., Liu, T., Ma, S., Luo, L., Guang, L., Liang, K., Ma, W., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12901 · Cited by 626 · see citing works
- Authors
- Vivodtzev, I., Moncharmont, L., Tamisier, R., Borel, J., Arbib, F., Wuyam, B., Lévy, P., Maltais, F., Ferretti, G., & Pépin, J.
- Affiliations
- Inserm (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Hypoxia Pathophysiology Laboratory, Inserm 1042 Grenoble Alps University Grenoble France
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Corresponding author
- Vivodtzev, Isabelle
- ORCID
- Venue
- Clinical Physiology and Functional Imaging
- Publisher
- Wiley
- Published
- 2017-11-03
- Volume
- 38
- Issue
- 5
- Pages
- 788-797
- ISSN
- 1475-0961 (ISSN-L)
- 1475-097X
- OpenAlex
- W2767194445
- Cited by
- 25
- References
- 58
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Physiology and Functional Imaging (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- chronic obstructive pulmonary disease, quadriceps, intramuscular fat infiltration, cardiometabolic risk, body mass index, obesity, arterial stiffness, endothelial dysfunction, antioxidant capacity, skeletal muscle fat
- MeSH terms
- Aged, Antioxidants, Endothelium, Vascular, Female, Forced Expiratory Volume, Humans, Lung, Male, Middle Aged, Obesity, Predictive Value of Tests, Prospective Studies, Risk Factors, Vital Capacity, Biomarkers, Body Mass Index, Metabolic Syndrome, Pulmonary Disease, Chronic Obstructive, Adiposity, Quadriceps Muscle, Vascular Stiffness, Multidetector Computed Tomography
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