Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial
Open accessAbstract
Considerable evidence suggests that the loss of strength and muscle mass appear to be inevitable consequences of aging. Moreover, aging is associated with an increase in body fat. This study examined whether increased physical activity could prevent or reverse the losses of strength and skeletal muscle mass as well as the gain in fat in older adults. Eleven men and 31 women completed a randomized trial consisting of either a physical activity (PA; n = 22) or successful aging health educational control (SA; n = 20) group. Isokinetic knee extensor strength and computed tomography-derived midthigh skeletal muscle and adipose tissue cross-sectional areas (CSA) were assessed at baseline and at 12 mo following randomization. Total body weight and muscle CSA decreased in both groups, but these losses were not different between groups. Strength adjusted for muscle mass decreased (-20.1 +/- 9.3%, P < 0.05) in SA. The loss of strength was completely prevented in PA (+2.5 +/- 8.3%). In addition, there was a significant increase (18.4 +/- 6.0%) in muscle fat infiltration in SA, but this gain was nearly completely prevented in PA (2.3 +/- 5.7%). In conclusion, regular physical activity prevents both the age-associated loss of muscle strength and increase in muscle fat infiltration in older adults with moderate functional limitations.
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In the LIFE pilot study, the control group at one year of aging showed an average 17% increase in IMAT.
“imaging in the control group at “one year of aging,” showed an average 17% increase in IMAT.”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Goodpaster et al., 2008
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- Authors
- Goodpaster, B. H., Chomentowski, P., Ward, B. K., Rossi, A., Glynn, N. W., Delmonico, M. J., Kritchevsky, S. B., Pahor, M., & Newman, A. B.
- Affiliations
- University of Pittsburgh (US)
- Wake Forest University (US)
- University of Florida (US)
- ORCID
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2008-11
- Volume
- 105
- Issue
- 5
- Pages
- 1498-1503
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- PMC
- PMC2584841
- OpenAlex
- W2120031015
- Cited by
- 446
- References
- 27
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 24 · 2023: 31 · 2022: 32 · 2021: 48 · 2020: 35 · 2019: 32 · 2018: 31 · 2017: 20 · 2016: 26 · 2015: 27 · 2014: 22 · 2013: 14 · 2012: 23
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR000064)
- National Institute on Aging (U01AG022376, P30AG028740, P30AG021332)
- National Center for Research Resources (UL1RR029890)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- physical activity, muscle strength, skeletal muscle fat infiltration, sarcopenia, successful aging, older adults, aging, muscle mass, adipose tissue, cross-sectional area, functional limitations, health education
- MeSH terms
- Aged, Aged, 80 and over, Aging, Female, Humans, Male, Muscular Diseases, Time Factors, Tomography, X-Ray Computed, Exercise, Muscle, Skeletal, Adiposity, Muscle Strength
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