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Cited by 88Periodontal Regeneration and TreatmentsOsteoarthritis Treatment and MechanismsTendon Structure and Treatment

The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.

MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis (Randomized Clinical Trial)

Open access
Raeissadat, Seyed Ahmad, Ghorbani, Elham, Sanei Taheri, Morteza, Soleimani, Reza, Rayegani, Seyed Mansoor, Babaee, Marzieh, Payami, Sara·2020·Journal of Pain Research
DOI 10.2147/jpr.s204788PMC PMC6959502
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Abstract

PURPOSE: Few papers have studied the objective effects of PRP on cartilage. In this study, we investigated the effect of PRP on cartilage characteristics by special MRI sequencing in knee osteoarthritis (IRCT registration number: 2014020413442N6). PATIENTS AND METHODS: In this double blind randomized clinical trial, patients with bilateral knees osteoarthritis-grade 1, 2, and 3 were included in the study. Each patient's knees were randomly allocated to either control or treatment groups. PRP was injected in two sessions with 4 week intervals in PRP group. The VAS (visual analog scale) and WOMAC (Western Ontario and McMaster Universities Arthritis Index) were utilized and MRI was performed for all patients, before, and 8 months after treatment. The MRI sequences taken were transverse 3D TRUFISP and coronal and sagittal fat saturated proton-density. Imaging was scored according to four cartilage characteristics. RESULTS: 46 knees (from 23 patients) were included in this study. 23 knees in the case group and 23 knees in control group were studied. All patients were female with mean age of 57.57±5.9 years. Mean total WOMAC and VAS changes before and after treatment in control group were 11.61±8.5 and 1.3±1.1 respectively. In PRP group, mean total WOMAC and VAS changes showed better improvement with 20±12.3 and 3.2±1.6 respectively (P-value <0.05). In PRP group, all of the radiologic variables (patellofemoral cartilage volume, synovitis and medial and lateral meniscal disintegrity), with the exception of subarticular bone marrow abnormality, had significant improvement (P-value <0.05). In a comparison between the two groups, patellofemoral cartilage volume and synovitis had significantly changed in the PRP group (P-value <0.05). CONCLUSION: In this study, in addition to the effect of PRP on VAS and WOMAC, there was a significant effect on radiologic characteristics (patellofemoral cartilage volume and synovitis). For further evaluation, a longer study with a larger sample size is recommended.

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Crossref · 10.2147/jpr.s204788

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  • In patients with knee osteoarthritis (KL grade 2-3), PRGF resulted in a WOMAC change of Δ-35.4% compared to hyaluronic acid.

    “WOMAC: PRGF Δ-35.4%; VAS: Δ-42.3%.”

    From Management of platelet-rich plasma and stem cells versus conventional treatments in musculoskeletal injury repair: A systematic review (2025) · cites this paper as [25]

    The Results report improved WOMAC scores after PRP treatment, but not a 35.4% change. The Methods and baseline table include KL grades 1–3, not only grades 2–3, and the trial compares PRP with a control group rather than PRGF with hyaluronic acid. Pages are not specified in our copy. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • In patients with knee osteoarthritis (KL grade 2-3), PRGF resulted in a VAS change of Δ-42.3% compared to hyaluronic acid.

    “WOMAC: PRGF Δ-35.4%; VAS: Δ-42.3%.”

    From Management of platelet-rich plasma and stem cells versus conventional treatments in musculoskeletal injury repair: A systematic review (2025) · cites this paper as [25]

    The Results (Tables 1–2; page unavailable) show that VAS improved in the PRP group, but they do not report a 42.3% change. The study included KL grades 1–3, used PRP rather than PRGF, and compared it with a control group rather than hyaluronic acid. The claimed percentage and comparison are therefore unsupported by this paper. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Metadata

Authors
Raeissadat, S. A., Ghorbani, E., Sanei Taheri, M., Soleimani, R., Rayegani, S. M., Babaee, M., & Payami, S.
Affiliations
  • Shahid Beheshti University (IR)
  • Shahid Beheshti University of Medical Sciences (IR)
  • Islamic Azad University, Tehran (IR)
Corresponding author
Babaee, Marzieh
ORCID
Venue
Journal of Pain Research
Publisher
Informa UK Limited
Published
2020-01
Volume
Volume 13
Pages
65-73
ISSN
1178-7090 (ISSN-L)
DOI
10.2147/jpr.s204788
PMC
PMC6959502
OpenAlex
W3000655318
Cited by
77
References
40
Citations by year
2026: 10 · 2025: 13 · 2024: 13 · 2023: 12 · 2022: 8 · 2021: 14 · 2020: 7
FWCI
11.66
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Pain Research (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
Keywords
platelet-rich plasma, knee osteoarthritis, cartilage, magnetic resonance imaging, synovitis

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