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Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) versus Hyaluronic Acid (A one-year randomized clinical trial)
Open accessAbstract
Introduction: Knee osteoarthritis (OA) is the most common articular disease. Different methods are used to alleviate the symptoms of patients with knee OA, including analgesics, physical therapy, exercise prescription, and intra-articular injections (glucocorticoids, hyaluronic acid [HA], etc). New studies have focused on modern therapeutic methods that stimulate cartilage healing process and improve the damage, including the use of platelet-rich plasma (PRP) as a complex of growth factors. Due to the high incidence of OA and its consequences, we decided to study the long-term effect of intraarticular injection of PRP and HA on clinical outcome and quality of life of patients with knee OA. Method: This non-placebo-controlled randomized clinical trial involved 160 patients affected by knee OA, grade 1–4 of Kellgren–Lawrence scale. In the PRP group ( n = 87), two intra-articular injections at 4-week interval were applied, and in the HA group ( n = 73), three doses of intra-articular injection at 1-week interval were applied. All patients were prospectively evaluated before and at 12 months after the treatment by Western Ontario and McMaster Universities Arthritis Index (WOMAC) and SF-36 questionnaires. The results were analyzed using SPSS 16.1 software (RCT code: IRCT2014012113442N5). Results: At the 12-month follow-up, WOMAC pain score and bodily pain significantly improved in both groups; however, better results were determined in the PRP group compared to the HA group ( P < 0.001). Other WOMAC and SF-36 parameters improved only in the PRP group. More improvement (but not statistically significant) was achieved in patients with grade 2 OA in both the groups. Conclusion: This study suggests that PRP injection is more efficacious than HA injection in reducing symptoms and improving quality of life and is a therapeutic option in select patients with knee OA who have not responded to conventional treatment.
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In patients with knee osteoarthritis (KL grade 1-4), PRP resulted in a WOMAC change of Δ-53.3% compared to hyaluronic acid.
“WOMAC: PRP Δ-53.3%; VAS: Δ-52.3%.”
From Management of platelet-rich plasma and stem cells versus conventional treatments in musculoskeletal injury repair: A systematic review (2025) · cites this paper as [27]
The Methods describe patients with Kellgren–Lawrence grade 1–4 knee osteoarthritis, and the Results report that total WOMAC scores improved significantly in the PRP group but not the hyaluronic-acid group (page unavailable). The copy does not report the claimed −53.3% WOMAC change. It also does not report the −52.3% VAS change in the citing sentence; the study used WOMAC and SF-36 as its outcome measures. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIn patients with knee osteoarthritis (KL grade 1-4), PRP resulted in a VAS change of Δ-52.3% compared to hyaluronic acid.
“WOMAC: PRP Δ-53.3%; VAS: Δ-52.3%.”
From Management of platelet-rich plasma and stem cells versus conventional treatments in musculoskeletal injury repair: A systematic review (2025) · cites this paper as [27]
The Methods (Abstract; page unavailable) identify patients with Kellgren–Lawrence grade 1–4 knee osteoarthritis, and the Results (Clinical outcomes of PRP and HA groups; page unavailable) report greater improvement in WOMAC pain with PRP than with HA. But this trial evaluated WOMAC and SF-36, not VAS, and our copy does not report a 52.3% VAS change. The Discussion mentions VAS only when describing other studies. (LLM, conf=0.87)
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Research works printed but not linked: 30
- 10.1002/art.23176 · DOI
- 10.1001/jama.290.18.2443 · DOI · Paper page
- 10.1016/j.reuma.2012.05.011 · DOI
- McArthur B.A., 2012, Patient Prefer Adherence., 6, 905
- 10.1007/s00167-011-1713-8 · DOI
- Rayegani S.R., 2014, Orthop Rev., 6, 112
- 10.1177/1941738111431801 · DOI
- 10.1016/j.arthro.2011.05.011 · DOI
- 10.1016/j.csm.2008.08.007 · DOI
- 10.1136/bjsm.2008.052761 · DOI
- 10.1016/j.jvs.2009.06.016 · DOI
- Sánchez M., 2008, Clin Exp Rheumatol., 26, 910
- Raeissadat S.A., 2014, Pain Res Treat., 2014, 191525
- 10.1016/j.tibtech.2008.11.009 · DOI
- 10.1016/j.fas.2013.08.002 · DOI
- 10.1186/2052-1847-6-12 · DOI
- 10.7453/gahmj.2012.054 · DOI
- Conduah A.H., 2009, J Pain Res., 2, 87
- 10.1186/1475-2891-7-3 · DOI
- Vincent K., 2013, Orthop J., 7, 378
- 10.7326/0003-4819-157-3-201208070-00473 · DOI · Paper page
- Miller L.E., 2013, Clin Med Arthritis Musculoskelet Disord., 6, 57
- 10.1016/j.csm.2008.08.007 · DOI
- 10.1016/j.apmr.2013.11.006 · DOI
- 10.1016/j.arthro.2013.09.006 · DOI
- 10.1097/01.jsm.0000432855.85143.e5 · DOI
- 10.1007/s11420-012-9320-x · DOI
- 10.1016/j.arthro.2013.07.264 · DOI
- 10.1186/1471-2474-13-229 · DOI
- Raeissadat S.A., 2013, Pain Res Treat., 2013, 165967
Cited by
Sorted by citations
MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis (Randomized Clinical Trial)
Raeissadat, S. A., Ghorbani, E., Sanei Taheri, M., Soleimani, R., Rayegani, S. M., Babaee, M., & Payami, S. (2020) · Journal of Pain Research · doi:10.2147/jpr.s204788 · Cited by 77
Self-citationRaeissadat, S. A., Rayegani, S. M., Ahangar, A. G., Abadi, P. H., Mojgani, P., & Ahangar, O. G. (2017) · Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders · doi:10.1177/1179544117733452 · Cited by 70
Self-citationLaPrade, R. F., Goodrich, L. R., Phillips, J., Dornan, G. J., Turnbull, T. L., Hawes, M. L., Dahl, K. D., Coggins, A. N., Kisiday, J., Frisbie, D., et al. (2018) · The American Journal of Sports Medicine · doi:10.1177/0363546517741135 · Cited by 51
Ballesta, F. J. G., Vásquez, L. N. A., Borbón, J. R., Leal, J. A. C., Agudelo, D. S. J., & Granados, J. P. A. (2025) · Journal of Musculoskeletal Surgery and Research · doi:10.25259/jmsr_402_2025
Metadata
- Authors
- Raeissadat, S. A., Rayegani, S. M., Hassanabadi, H., Fathi, M., Ghorbani, E., Babaee, M., & Azma, K.
- Affiliations
- Shahid Beheshti University (IR)
- Mashhad University of Medical Sciences (IR)
- Aja University of Medical Sciences (IR)
- Corresponding author
- Ghorbani, Elham
- Venue
- Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
- Publisher
- SAGE Publications
- Published
- 2015-01
- Volume
- 8
- Pages
- CMAMD.S17894
- ISSN
- 1178-1149 (ISSN-L)
- 1179-5441
- PMC
- PMC4287055
- OpenAlex
- W2088653124
- Cited by
- 331
- References
- 0
- Citations by year
- 2026: 21 · 2025: 21 · 2024: 22 · 2023: 23 · 2022: 37 · 2021: 27 · 2020: 50 · 2019: 30 · 2018: 37 · 2017: 28 · 2016: 28 · 2015: 7
- FWCI
- 28.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Clinical Medicine Insights Arthritis and Musculoskeletal Disorders (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Keywords
- knee osteoarthritis, platelet-rich plasma, hyaluronic acid, intra-articular injection, growth factors, cartilage repair, analgesia, quality of life, WOMAC, SF-36, treatment efficacy comparison
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