Comparison of the Efficacy Between Standard Measurement-Base Care (MBC) and Enhanced MBC for Major Depressive Disorder: A Pilot Study
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Purpose: To validate the efficacy of enhanced measurement-based care against standard measurement-based care in patients with major depressive disorder. Patients and Methods: In this pilot study of an ongoing multicenter cluster randomized controlled trails, 160 patients diagnosed with major depressive disorder were enrolled from 2 mental health centers, with a plan to include 12 centers in total. One hundred patients engaged in a six-month evaluation using a technology-enhanced measurement-based care tool, including assessments of clinical symptoms, side effects, and functionality at baseline, two months, four months and six months. Simultaneously, the remaining 60 patients underwent standard paper-based measurement-based care, utilizing the same set of scales over the same six-month period, with assessments at the same time points. Results: Patients utilizing the enhanced measurement-based care tool demonstrated a significantly higher reduction rate in PHQ-9 scores compared to those using standard paper-based measurement-based care during the two-month follow-up. Additionally, a notable positive correlation was observed between the frequency of enhanced measurement-based care tool usage and the quality of life during the two-month follow-up. Conclusion: Enhanced measurement-based care has the effect of reducing depressive symptoms. Our study emphasized that using enhanced measurement-based care via smartphones is a feasible tool for patients with major depressive disorder. Our future study, including results from additional research centers, may further validate the effectiveness of enhanced measurement-based care.
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Remote recording tools via the internet or smartphones allow patients to complete self-assessments at home and reduce participant burden and the need for frequent clinic visits.
“Remote recording tools via the internet or smartphones allow patients to complete self-assessments at home27,28 and reduce participant burden and the need for frequent clinic visits.”
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Cites
A Brief Measure for Assessing Generalized Anxiety Disorder: The GAD-7
Spitzer, R. L., Kroenke, K., Williams, J. B. W., & Löwe, B. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.10.1092 · Cited by 31,765 · see citing works
The American Psychological Association
Langfeld, H. S. (1919) · Science · doi:10.1126/science.49.1254.51 · Cited by 7,453 · see citing works
The PHQ-9: A New Depression Diagnostic and Severity Measure
Kroenke, K., & Spitzer, R. L. (2002) · Psychiatric Annals · doi:10.3928/0048-5713-20020901-06 · Cited by 5,898 · see citing works
Malhi, G. S., & Mann, J. J. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31948-2 · Cited by 4,099 · see citing works
Depression Is the Leading Cause of Disability Around the World
Friedrich, M. J. (2017) · JAMA · doi:10.1001/jama.2017.3826 · Cited by 1,459 · see citing works
Bupropion-SR, Sertraline, or Venlafaxine-XR after Failure of SSRIs for Depression
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Stewart, J. W., Nierenberg, A. A., Thase, M. E., Ritz, L., Biggs, M. M., Warden, D., Luther, J. F., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052963 · Cited by 1,033 · see citing works
Assessing Psychiatric Impairment in Primary Care with the Sheehan Disability Scale
Leon, A. C., Olfson, M., Portera, L., Farber, L., & Sheehan, D. V. (1997) · The International Journal of Psychiatry in Medicine · doi:10.2190/t8em-c8yh-373n-1uwd · Cited by 987 · see citing works
Risk factors for suicide in China: a national case-control psychological autopsy study
Phillips, M. R., Yang, G., Zhang, Y., Wang, L., Ji, H., & Zhou, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11681-3 · Cited by 928 · see citing works
Michie, S., Yardley, L., West, R., Patrick, K., & Greaves, F. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.7126 · Cited by 865 · see citing works
Costantini, L., Pasquarella, C. I. M., Odone, A., Colucci, M. E., Costanza, A., Serafini, G., Aguglia, A., Murri, M. B., Brakoulias, V., Amore, M., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.131 · Cited by 740 · see citing works
Malhi, G. S., Bell, E., Bassett, D., Boyce, P., Bryant, R., Hazell, P., Hopwood, M., Lyndon, B., Mulder, R., Porter, R., et al. (2021) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867420979353 · Cited by 614 · see citing works
Implementing Measurement-Based Care in Behavioral Health: A Review
Lewis, C. C., Boyd, M., Puspitasari, A., Navarro, E., Howard, J., Kassab, H., Hoffman, M., Scott, K., Lyon, A., Douglas, S., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.3329 · Cited by 605 · see citing works
A Tipping Point for Measurement-Based Care
Fortney, J. C., Unützer, J., Wrenn, G. L., Pyne, J. M., Smith, G. R., Schoenbaum, M., & Harbin, H. T. (2016) · Psychiatric Services · doi:10.1176/appi.ps.201500439 · Cited by 568 · see citing works
Treatment engagement of individuals experiencing mental illness: review and update
Dixon, L. B., Holoshitz, Y., & Nossel, I. (2016) · World Psychiatry · doi:10.1002/wps.20306 · Cited by 550 · see citing works
Implementing routine outcome monitoring in clinical practice: Benefits, challenges, and solutions
Boswell, J. F., Kraus, D. R., Miller, S. D., & Lambert, M. J. (2015) · Psychotherapy Research · doi:10.1080/10503307.2013.817696 · Cited by 494 · see citing works
Using Measurement-Based Care to Enhance Any Treatment
Scott, K., & Lewis, C. C. (2015) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2014.01.010 · Cited by 461 · see citing works
Hatfield, D., McCullough, L., Frantz, S. H. B., & Krieger, K. (2010) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.656 · Cited by 321 · see citing works
Self-Rated Global Measure of the Frequency, Intensity, and Burden of Side Effects
Wisniewski, S. R., Rush, A. J., Balasubramani, G. K., Trivedi, M. H., & Nierenberg, A. A. (2006) · Journal of Psychiatric Practice · doi:10.1097/00131746-200603000-00002 · Cited by 288 · see citing works
Why Some Clinicians Use Outcome Measures and Others Do Not
Hatfield, D. R., & Ogles, B. M. (2007) · Administration and Policy in Mental Health and Mental Health Services Research · doi:10.1007/s10488-006-0110-y · Cited by 164 · see citing works
Steinert, C., Hofmann, M., Kruse, J., & Leichsenring, F. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.017 · Cited by 148 · see citing works
Zimmerman, M., Martinez, J. A., Attiullah, N., Friedman, M., Toba, C., Boerescu, D. A., & Rahgeb, M. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11m07203 · Cited by 109 · see citing works
Lam, R. W. M., Kennedy, S. H., Parikh, S. V., MacQUEEN, G. M., Milev, R. V., Ravindran, A. V., & the CANMAT Depression Work Group (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716659061 · Cited by 94 · see citing works
Self-citationFunctional Versus Syndromal Recovery in Patients With Major Depressive Disorder and Bipolar Disorder
van der Voort, T. Y. G., Seldenrijk, A., van Meijel, B., Goossens, P. J. J., Beekman, A. T. F., Penninx, B. W. J. H., & Kupka, R. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09548 · Cited by 86 · see citing works
Orsolini, L., Pompili, S., Salvi, V., & Volpe, U. (2021) · Medicina · doi:10.3390/medicina57080793 · Cited by 85 · see citing works
The Efficacy of Measurement-Based Care for Depressive Disorders
Zhu, M., Hong, R. H., Yang, T., Yang, X., Wang, X., Liu, J., Murphy, J., Michalak, E. E., Wang, Z., Yatham, L. N., et al. (2021) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.21r14034 · Cited by 69 · see citing works
Self-citationSchmidt, U. H., Landau, S., Pombo‐Carril, M. G., Bara‐Carril, N., Reid, Y., Murray, K. A., Treasure, J. L., & Katzman, M. A. (2006) · British Journal of Clinical Psychology · doi:10.1348/014466505x29143 · Cited by 61 · see citing works
Zheng, W., Li, X.-H., Zhu, X.-M., Cai, D.-B., Yang, X.-H., Ungvari, G. S., Ng, C. H., Ning, Y.-P., Hu, Y.-D., He, S.-H., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.02.044 · Cited by 55 · see citing works
Self-citationOptimization Strategies of Transcranial Magnetic Stimulation in Major Depressive Disorder
Wen, K.-S., & Zheng, W. (2024) · ALPHA PSYCHIATRY · doi:10.5152/alphapsychiatry.2023.231401 · Cited by 45 · see citing works
Yuan, S., Luo, X., & Zhang, B. (2024) · ALPHA PSYCHIATRY · doi:10.5152/alphapsychiatry.2023.231412 · Cited by 34 · see citing works
Murphy, J., Michalak, E. E., Liu, J., Colquhoun, H. L., Burton, H., Yang, X., Yang, T., Wang, X., Fei, Y., He, Y., et al. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03442-5 · Cited by 20 · see citing works
Self-citationLawrence‐Sidebottom, D., Huffman, L. G., Huberty, J., Beatty, C. C., Roots, M., Roots, K., Parikh, A., Guerra, R., & Weiser, J. (2023) · JMIR Formative Research · doi:10.2196/46578 · Cited by 20 · see citing works
Faurholt‐Jepsen, M., Frost, M. M., Christensen, E. M., Bardram, J. E., Vinberg, M., & Kessing, L. V. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13021 · Cited by 16 · see citing works
Harnessing Technology to Implement Measurement-Based Care
Black, W. E., Nagarkatti‐Gude, D. R., JETMALANI, A. N., & Keepers, G. A. (2018) · Academic Psychiatry · doi:10.1007/s40596-018-0929-z · Cited by 15 · see citing works
Hickie, I. B., Iorfino, F., Rohleder, C., Song, Y. J. C., Nichles, A., Zmicerevska, N., Capon, W., Guastella, A. J., Leweke, F. M., Scott, J. L., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-072082 · Cited by 9 · see citing works
Tardive Dyskinesia: Legal Issues and Consent
Gupta, S., Frank, B. L., & Madhusoodanan, S. (2002) · Psychiatric Annals · doi:10.3928/0048-5713-20020401-09 · Cited by 8 · see citing works
Person‐centered measurement‐based care for depression
Uher, R. (2016) · World Psychiatry · doi:10.1002/wps.20363 · Cited by 8 · see citing works
Khatib, R., McCue, M., Blair, C., Roy, A., Franco, J., Fehnert, B., King, J., Sarkey, S., Chrones, L., Martin, M., et al. (2023) · JMIR Research Protocols · doi:10.2196/43788 · Cited by 5 · see citing works
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- [28]Lam RW, Chen J, Michalak E, et al. EMBED Phase 2 study protocol v.1.4: a cluster randomized controlled trial of enhanced versus standard measurement-based care implementation for depression. OSF Preprints. 2021. doi: 10.31219/osf.io/9z82u.Lam · DOI
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Lam, R. W., Rnic, K., Nunez, J.-J., Ho, K., LeMoult, J., Nunes, A., Chakrabarty, T., Foster, J. A., Frey, B. N., Harkness, K. L., et al. (2025) · The Canadian Journal of Psychiatry · doi:10.1177/07067437251337603 · Cited by 6 · see citing works
Self-citationAskari, N., Gupta, R., Hussain‐Shamsy, N., Barker, L. C., Champagne, T., Lam, R. W. M., Bishop, K., Pirmohamed, J., Michalowska, M., Shah, V., et al. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06876-3 · Cited by 1 · see citing works
Self-citationThe state of implementation science in major depressive disorder: A narrative review
He, Y., Murphy, J., Wang, X., Michalak, E. E., Yang, T., Yang, X., Liu, J., Fang, Y., Lam, R. W. M., & Chen, J. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.116330 · Cited by 1 · see citing works
Self-citationLam, R. W. M., Michalak, E. E., Murphy, J., Colquhoun, H. L., Ng, C. H., Culpepper, L., Dewa, C. S., Greenshaw, A. J., He, Y., Kennedy, S. H., et al. (2025) · Cureus · doi:10.7759/cureus.90395
Self-citationReese, T. J., Audet, C. M., Ancker, J. S., Wright, A. T., Marcovitz, D. E., Kast, K. A., Bridges, J. F. P., Tindle, H. A., Shah, M. V., von Horn, A., et al. (2026) · medRxiv · doi:10.64898/2026.08.27.26361539
- Authors
- He, Y., Wang, X., Wang, Z., Zhang, P., Huang, X., Yu, M., Murphy, J., Michalak, E., Liu, J., Yang, T., Yang, X., Fang, Y., Lam, R., & Chen, J.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Shanghai University (CN)
- University of British Columbia (CA)
- Corresponding author
- Lam, Raymond
- Chen, Jun
- ORCID
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2024-07
- Volume
- Volume 20
- Pages
- 1465-1473
- ISSN
- 1176-6328 (ISSN-L)
- 1178-2021
- PMC
- PMC11296504
- OpenAlex
- W4401089222
- Cited by
- 5
- References
- 37
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- National Natural Science Foundation of China (81930033, 81761128032, 2018B030334001, 81771465)
- Shanghai Clinical Research Center (19MC1911100)
- Special Project for Research and Development in Key areas of Guangdong Province (2018B030334001)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- measurement-based care, major depressive disorder, smartphone-based assessment, PHQ-9, depressive symptom reduction, quality of life, digital mental health tools
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