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Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder
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Adenylate-cyclase activity in platelets of patients with obsessive-compulsive disorder D Marazziti, S Baroni, L Palego, I Masala, G Consoli, M Catena Dell’Osso, G Giannaccini, A LucacchiniDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Pisa, ItalyAbstract: Although the main biological hypothesis on the pathophysiology of obsessive-compulsive disorder (OCD) is centered on the serotonin system, indications are available that other neurotransmitters, and even second messengers, particularly the cyclic adenosine monophosphate (cAMP) signaling, may be involved, though effective data are few. Therefore, the aim of the present study was to evaluate and compare the basal and isoprenaline (ISO)-stimulated velocity of adenylate-cyclase (AC) in human platelet membranes of patients with OCD and healthy control subjects. The results showed that the basal and ISO-stimulated AC activity, as well as the dose-response curves of ISO by using agonist concentrations ranging between 0.1 nM and 10 µM, were not different in the two groups. However, OCD patients showed lower EC50 and higher Emax values than healthy subjects. These findings suggest the presence of supersensitive β-adrenergic receptors in platelets of OCD patients.Keywords: obsessive-compulsive disorder, norepinephrine, second messengers, adenylate-cyclase, platelets, isoprenaline, β-adrenergic receptors
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Plasma catecholamines and metabolites are not changed in OCD, concurring with no change in cerebrospinal fluid concentrations of biogenic amines and metabolites, while supersensitive beta-adrenergic receptors are measured in platelets of OCD patients.
“plasma catecholamines and metabolites are not changed in OCD (Benkelfat et al. 1991) concurring with no change in cerebrospinal fluid (CSF) concentrations of biogenic amines and metabolites (Leckman et al. 1995), supersensitive beta-adrenergic receptors are measured by detecting adenylate cyclase activity in platelets of OCD patients (Marazziti et al. 2009).”
From The neurobiological link between OCD and ADHD (2014) · cites this paper as Marazziti et al. 2009
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The neurobiological link between OCD and ADHD
Brem, S., Grünblatt, E., Drechsler, R., Riederer, P., & Walitza, S. (2014) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-014-0146-x · Cited by 109
The Psychopharmacology of Obsessive-Compulsive Disorder: A Preclinical Roadmap
Szechtman, H., Harvey, B. H., Woody, E. Z., & Hoffman, K. L. (2019) · Pharmacological Reviews · doi:10.1124/pr.119.017772 · Cited by 41
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Metadata
- Authors
- Marazziti, D.
- Affiliations
- University of Pisa (IT)
- Corresponding author
- Marazziti, Donatella
- ORCID
- Marazziti, Donatella
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2009-07
- Volume
- 5
- Pages
- 363
- ISSN
- 1176-6328 (ISSN-L)
- PMC
- PMC2706568
- OpenAlex
- W2053135642
- Cited by
- 3
- References
- 21
- Citations by year
- 2019: 1 · 2015: 1 · 2014: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, adenylate cyclase, platelets, cAMP signaling, beta-adrenergic receptors, isoproterenol, second messengers, norepinephrine, serotonergic system, receptor supersensitivity
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