Perspectives on reasons of medication nonadherence in psychiatric patients
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PURPOSE: This study was carried out to evaluate factors resulting in medication nonadherence within 6 months before admission to the psychiatric service of our hospital for bipolar disorder, schizophrenia/schizoaffective disorder, depression, and other psychiatric diseases. PATIENTS AND METHODS: Two hundred and three patients admitted to the Psychiatry Service of the Medical Faculty were included in this study. Sociodemographic parameters and clinical findings within 6 months before admission and patients' views on reasons of medication nonadherence were examined. RESULTS: Patients were classified into four groups according to their diagnosis: bipolar disorder (n=68, 33.5%), schizophrenia/schizoaffective disorder (n=59, 29.1%), depression (n=39, 19.2%), and others (n=37, 18.2%). The ratio of medication nonadherence was higher in the bipolar disorder group when compared to the groups with schizophrenia/schizoaffective disorder, depression, and other disorders (12.1%, 18.2%, and 24.2% vs 45.5%); however, the ratio of medication nonadherence was similar in schizophrenia/schizoaffective disorder, depression, and the others group. In logistic regression analysis, irregular follow-up (odds ratio [OR]: 5.7; 95% confidence interval [CI]: 2.92-11.31) and diagnosis (OR: 1.5; 95% CI: 1.07-1.95) were determined to be important risk factors for medication nonadherence. The leading factors for medication nonadherence were: "not willing to use medication", "not accepting the disease", and "being disturbed by side effects" in the bipolar disorder group, "not accepting the disease" in the schizophrenia/schizoaffective disorder group, "feeling well" in the depression group, and "being disturbed by side effects" in the other diseases group. CONCLUSION: Medication nonadherence is an important problem in psychiatric patients and should be dealt with by taking into account the diagnosis, attendance to follow-up appointments, and the patient's attitude. Ensuring regular attendance to follow-up appointments, adjusting the management plan according to the diagnosis, and improving their thoughts about resistance to medication can be beneficial in terms of medication adherence.
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Psychiatric patients may attribute antipsychotic medication non-adherence to alterations in cognitive and attitudinal functioning and therefore be unwilling to use the medication in three studies.
“In three studies, psychiatric patients may also attribute to antipsychotic medication non-adherence due to the alterations in cognitive and attitudinal functioning and therefore be unwilling to use the medication [29, 37, 38].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [29]
Psychotropic medication non-adherence was associated with medication-related side-effects in several studies.
“In several studies, psychotropic medication non-adherence was associated with medication-related side-effects [11, 22–25, 28–30, 32–37, 39, 44, 50, 52, 55, 64, 65].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [29]
Both psychostimulant and psycho-depressant substances misuse were associated with psychotropic medication non-adherence in eight studies.
“In eight studies, both psychostimulant and psycho-depressant substances misuse were associated with psychotropic medication non-adherence [23, 27, 29, 37, 42, 43, 58, 65].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [29]
Having long-term medication prescriptions, long duration maintenance therapy, and irregular follow-up were associated with psychotropic medication non-adherence.
“Similarly, having long-term medication prescriptions, long duration maintenance therapy [29, 54], and irregular follow-up [29] were associated with psychotropic medication non-adherence.”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [29]
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Motives for Substance Use Among Male Psychiatric Inpatients with Psychotic Disorders
Ţăpoi, C., & Ogamdi, E. C. (2026) · Psychiatry International · doi:10.3390/psychiatryint7030120
Wazlawik, S., & Oppenauer, C. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-08271-y
Medication Adherence Views of Mental Health Nurses to Inspire Transformative Care
Alyahya, N. M. (2026) · Creative Nursing · doi:10.1177/10784535261490954
- Authors
- Mert, D. G., Turgut, N. H., Kelleci, M., & Semiz, M.
- Affiliations
- Sivas Cumhuriyet Üniversitesi (TR)
- Corresponding author
- Mert, Derya Güliz
- Venue
- Patient Preference and Adherence
- Publisher
- Informa UK Limited
- Published
- 2015-01
- Volume
- 9
- Pages
- 87
- ISSN
- 1177-889X (ISSN-L)
- PMC
- PMC4298301
- OpenAlex
- W2082950359
- Cited by
- 70
- References
- 23
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 10 · 2023: 17 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 4
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Patient Preference and Adherence (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- medication non-adherence, psychiatric patients, bipolar disorder, schizophrenia, schizoaffective disorder, depression, risk factors, follow-up attendance, adverse drug reactions, patient attitudes, acceptance of illness
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