Medication nonadherence and psychiatry
Open accessAbstract
PURPOSE OF REVIEW: Nonadherence to appropriately prescribed medication for psychiatric disorders prevents patients from realizing the full benefits of their treatment and negatively impacts on individuals, their families and the healthcare system. Understanding and reducing nonadherence is therefore a key challenge to quality care for patients with psychiatric disorders. This review highlights findings regarding the prevalence and consequence of nonadherence, barriers to adherence and new intervention methods from 2012 onwards. RECENT FINDINGS: Recent research has highlighted that nonadherence is a global challenge for psychiatry and has linked nonadherence to poorer outcomes, including hospital admissions, suicide and mortality. Optimizing medication regimens can reduce nonadherence; however, often a complex interplay of factors affects individuals' motivation and ability to follow their prescription. Psychiatrists can enable patients to develop an accurate model of their illness and treatment and facilitate adherence. However, nonadherence is often a hidden issue within consultations. Novel interventions using new technologies and tailoring techniques may have the potential to reduce nonadherence. SUMMARY: Nonadherence remains a significant challenge for patients with psychiatric disorders, physicians and healthcare systems. New developments demonstrate the importance of developing tailored interventions to enable patients to overcome perceptual and practical barriers to adherence.
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This systematic review of factors influencing psychotropic medication non-adherence, consistent with other systematic reviews, has shown that medication adherence is mainly affected by patients' negative attitude toward their medication, lack of insight, negative health belief, and perceived stigma.
“This systematic review of factors influencing psychotropic medication non-adherence which is consistent with other systematic reviews [14, 72, 73, 77] has shown that medication adherence is mainly affected by patients’ negative attitude toward their medication, lack of insight, negative health belief, and perceived stigma.”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [73]
Financial factors seriously affected medication adherence, including unaffordability of medication, increased health care cost, lack of health insurance, patients' poor capacity, and limited resources.
“Financial factors seriously affected medication adherence. These included unaffordability of medication, increased health care cost [73, 74], lack of health insurance [75], patients’ poor capacity, and limited resources [73].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [73]
Previous systematic reviews have indicated that medication non-adherence is a common challenge in the treatment of psychiatric disorders.
“Previous systematic reviews have indicated that medication non-adherence is a common challenge in the treatment of psychiatric disorders [72, 73].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [73]
Medication non-adherence is associated with clinical- or medication-related factors.
“In addition, medication non-adherence is associated with clinical- or medication-related factors [14, 72–74, 77].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [73]
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- Authors
- Chapman, S. C. E., & Horne, R.
- Affiliations
- UCL School of Pharmacy (GB)
- ORCID
- Chapman, Sarah C.E.
- Venue
- Current Opinion in Psychiatry
- Published
- 2013-09
- Volume
- 26
- Issue
- 5
- Pages
- 446-452
- ISSN
- 0951-7367 (ISSN-L)
- PMC
- PMC4222796
- OpenAlex
- W2026767598
- Cited by
- 142
- References
- 57
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 15 · 2021: 18 · 2020: 18 · 2019: 11 · 2018: 15 · 2017: 12 · 2016: 7 · 2015: 11 · 2014: 4 · 2013: 1
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Current Opinion in Psychiatry (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0510-10197, PB-PG-1207-15248)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Keywords
- medication non-adherence, mental illness, barriers to adherence, adherence interventions, personalized interventions, technology-based interventions, hospitalization, suicide, mortality, physician-patient relationship, illness model
- MeSH terms
- Assessment of Medication Adherence, Mental Disorders, Humans, Health Behavior, Drug Monitoring, Medication Adherence
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